Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1.

scientific article

Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.273.21.13089
P698PubMed publication ID9582347
P5875ResearchGate publication ID13702424

P2093author name stringOtsu M
Shimada Y
Okamoto T
Nakanishi S
Sato A
Jingami H
Sekiyama N
P2860cites workExpression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptorsQ24308093
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptorsQ24563191
Structure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structureQ27702515
Sequence and expression of a metabotropic glutamate receptorQ28280066
Molecular diversity of glutamate receptors and implications for brain functionQ28611078
Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroidQ29614810
Pharmacology and functions of metabotropic glutamate receptorsQ29619150
Cloned glutamate receptorsQ29619950
A family of metabotropic glutamate receptorsQ31159811
Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor functionQ37388887
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonistsQ37873606
Molecular diversity and functions of glutamate receptorsQ40627850
Structure and function of G protein-coupled receptorsQ40642980
Expanding horizons for receptors coupled to G proteins: diversity and diseaseQ40668287
Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).Q40963972
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteinsQ41074853
A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.Q41186190
Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor. Lys583 is essential and irreplaceable for human choriogonadotropin (hCG)-dependent receptor activation but not for high affinity hCG bindingQ41213281
Lys583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signalingQ41239610
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptorsQ41295315
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypesQ41990665
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acidQ42554698
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulationQ43424561
Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cellsQ48118136
Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neuronesQ48263956
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptorsQ48283295
Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cellsQ48504114
Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria.Q54099620
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulbQ59082970
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectligand bindingQ61659151
P304page(s)13089-13096
P577publication date1998-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleExpression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1.
P478volume273

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cites work (P2860)
Q40999141A carboxyl-terminal domain controls the cooperativity for extracellular Ca2+ activation of the human calcium sensing receptor. A study with receptor-green fluorescent protein fusions
Q44336537A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity
Q48244540Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum
Q28210064Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain
Q28566794Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor
Q38360707Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state
Q43192167An efficient Escherichia coli expression system for the production of a functional N-terminal domain of the T1R3 taste receptor
Q38318294Association analysis of the GRM8 gene with schizophrenia in the Uygur Chinese population
Q28362867BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity
Q37773024Brain receptor mosaics and their intramembrane receptor-receptor interactions: molecular integration in transmission and novel targets for drug development
Q36510503Calcium sensing receptors and calcium oscillations: calcium as a first messenger
Q46681117Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).
Q40811646Cell type-specific differences in the coupling of recombinant mGlu1alpha receptors to endogenous G protein sub-populations
Q43509970Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections
Q34070596Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni
Q33910806Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.
Q28203529Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene
Q33863637Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1alpha
Q28374105Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8
Q40887798Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution.
Q28373279Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors
Q40832497Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor
Q24290099Cys-140 is critical for metabotropic glutamate receptor-1 dimerization
Q38335448Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.
Q38325895Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys --> Ser mutations at Cys101 and Cys236.
Q40029292Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor
Q33910258Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3
Q40746573Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor
Q28754701Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence
Q35143358Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
Q40950157Expression and characterization of a glycine-binding fragment of the N-methyl-D-aspartate receptor subunit NR1.
Q40962035Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor
Q33953071Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor
Q57609677Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
Q42488693Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor
Q42724469Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye.
Q34502401G protein-coupled receptors: dominant players in cell-cell communication
Q35556404GFP-based evaluation system of recombinant expression through the secretory pathway in insect cells and its application to the extracellular domains of class C GPCRs
Q31913735Genomic organization of the human metabotropic glutamate receptor subtype 3.
Q35917743Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts.
Q37346878Heterodimers and receptor mosaics of different types of G-protein-coupled receptors
Q37120246How and why do GPCRs dimerize?
Q40889611Human Ca2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors
Q33944978Identification of a novel member of the T1R family of putative taste receptors
Q31942764Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina
Q40928819Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor
Q38291585Internalization of metabotropic glutamate receptor in C6 cells through clathrin-coated vesicles
Q42056331Large-scale expression and thermodynamic characterization of a glutamate receptor agonist-binding domain
Q28373018Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor
Q33952110Ligand-induced signal transduction within heterodimeric GABA(B) receptor
Q27628494Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core
Q33695742Metabotropic G-protein-coupled glutamate receptors as therapeutic targets
Q51396445Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.
Q34248541Metabotropic glutamate receptors: structure and new subtype-selective ligands.
Q48404136Metabotropic glutamate receptors: targets for therapy of cerebral ischaemia
Q73574719Mobilisation of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones
Q37782429Molecular biological research on olfactory chemoreception in fishes
Q34105227Molecular determinants of high affinity binding to group III metabotropic glutamate receptors
Q32140641Molecular determinants of metabotropic glutamate receptor signaling.
Q50719477Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.
Q44545611Molecular similarities in the ligand binding pockets of an odorant receptor and the metabotropic glutamate receptors
Q24534016Molecular tinkering of G protein-coupled receptors: an evolutionary success
Q40957427Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding
Q34325447Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues
Q40997378Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction
Q33910436Mutational analysis of the structure and function of opioid receptors
Q44938121Negative cooperativity of glutamate binding in the dimeric metabotropic glutamate receptor subtype 1.
Q33709295New perspectives for the development of selective metabotropic glutamate receptor ligands.
Q24301599Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking
Q40708553No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.
Q33756933Pharmacological agents acting at subtypes of metabotropic glutamate receptors
Q42047119Pharmacological characterization and immunoaffinity purification of metabotropic glutamate receptor from Drosophila overexpressed in Sf9 cells
Q40837866Pharmacological profiles of the metabotropic glutamate receptor ligands
Q40697123Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).
Q38318509Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor
Q64108781Production of Bioactive Compounds by Food Associated 38, as Determined by Proteome Analysis
Q54049523Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors.
Q77788219Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor
Q46596775Structural and biochemical views of metabotropic glutamate receptor activation
Q27627995Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
Q47653448Structural biology of GABAB receptor
Q27680758Structural mechanism of ligand activation in human GABAB receptor
Q27638103Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.
Q28362372Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors
Q35172787Structure of the metabotropic glutamate receptor
Q44241682Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists
Q40947546The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
Q44873595The modeling of the structure of the cysteine-rich domain of metabotropic glutamate receptors
Q33889992The molecular architecture of odor and pheromone sensing in mammals
Q35575376The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids
Q40874487The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity
Q42640637Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process
Q83066102Umami taste in mice uses multiple receptors and transduction pathways
Q41336717mGluR6 transcripts in non-neuronal tissues

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