Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase

scientific article

Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.23.4.1441-1452.2003
P932PMC publication ID141154
P698PubMed publication ID12556502

P50authorWolf-Dietrich HeyerQ63309380
P2093author name stringVladimir I Bashkirov
Edwin Haghnazari
Elena V Bashkirova
P2860cites workHeterozygous germ line hCHK2 mutations in Li-Fraumeni syndromeQ22011001
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2Q24319816
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1Q24551095
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroQ24656275
II. Structure and specificity of the interaction between the FHA2 domain of Rad53 and phosphotyrosyl peptidesQ27627122
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanismsQ27628846
Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathwayQ39459511
Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1Q39530422
Chk2 activation and phosphorylation-dependent oligomerizationQ39674829
Mitotic DNA damage and replication checkpoints in yeastQ40352474
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputsQ41331128
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damageQ41854894
The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factorsQ42672394
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.Q42687620
Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.Q43711748
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiaeQ46200700
DUN1 encodes a protein kinase that controls the DNA damage response in yeastQ48087375
The riddle of MAP kinase signaling specificityQ58212672
Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathwaysQ58883742
DNA damage checkpoints update: getting molecularQ62657002
A DNA damage response pathway controlled by Tel1 and the Mre11 complexQ64388109
Regulation of SNM1, an inducible Saccharomyces cerevisiae gene required for repair of DNA cross-linksQ71073759
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanismsQ73153090
Analysis of budding yeast kinases controlled by DNA damageQ73572483
Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinaseQ73693369
FHA: a signal transduction domain with diverse specificity and functionQ74471745
MEC1-dependent phosphorylation of Rad9p in response to DNA damageQ77231583
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2Q27639080
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstateQ27639362
The protein kinase family: conserved features and deduced phylogeny of the catalytic domainsQ27860528
The conformational plasticity of protein kinasesQ27860946
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryQ27861116
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinaseQ27930725
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiaeQ27933444
Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiaeQ27933460
The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondriaQ27933751
SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.Q27935086
Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocksQ27935124
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressorQ27935222
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathwayQ27935644
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpointQ27937738
A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP poolsQ27938474
A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription.Q27938547
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayQ27938580
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpointQ27939822
The DNA damage response: putting checkpoints in perspectiveQ28131713
Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domainQ28207961
Replacement of chromosome segments with altered DNA sequences constructed in vitroQ29614231
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathwaysQ29615271
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeastQ29620732
RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeastQ30448350
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.Q30657462
Rad54 protein stimulates heteroduplex DNA formation in the synaptic phase of DNA strand exchange via specific interactions with the presynaptic Rad51 nucleoprotein filamentQ30663367
The FHA domain is a modular phosphopeptide recognition motif.Q33285631
Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpointQ33285672
Sir-Ku-itous routes to make ends meetQ33684024
Sensing and responding to DNA damage.Q33840475
DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpointsQ33963987
The FHA domain mediates phosphoprotein interactions.Q34078695
Regulation of G protein-initiated signal transduction in yeast: paradigms and principlesQ34275492
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)1441-1452
P577publication date2003-02-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDirect kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase
P478volume23

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cites work (P2860)
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