Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion

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Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCHEMBIO.1130
P932PMC publication ID3556477
P698PubMed publication ID23160003
P5875ResearchGate publication ID233537374

P2093author name stringDerek S Tan
Renato A Bauer
Todd A Wenderski
P2860cites workLowering the entropic barrier for binding conformationally flexible inhibitors to enzymesQ27766090
Characteristics in the reactions of allylsilanes and their applications to versatile synthetic equivalentsQ30054146
Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platformQ31038453
A solution- and solid-phase approach to tetrahydroquinoline-derived polycyclics having a 10-membered ringQ33206660
Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approachQ33359155
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspectiveQ33536938
An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase InhibitorsQ33743418
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like libraryQ33857987
Molecular properties that influence the oral bioavailability of drug candidatesQ34130727
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansionQ34190644
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.Q37371583
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.Q46001611
Total synthesis of the aspercyclides.Q46024123
Quantitative comparison of the relative cell permeability of cyclic and linear peptides.Q53545017
Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea.Q55061546
Hydrofluoric acid catalyzed intramolecular Diels-Alder reactionsQ56698958
Flavonone and chalcone derivatives from Cryptocarya kurziiQ72933416
Enantioselective total synthesis of (-)-heliannuol AQ73071107
Ellagitannin ChemistryQ77646202
Aspercyclide A–C, three novel fungal metabolites from Aspergillus sp. as inhibitors of high-affinity IgE receptorQ78297209
Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactionsQ79139293
Conformational constraint in protein ligand design and the inconsistency of binding entropyQ80856569
Total synthesis of aspercyclide CQ81633084
Neodihydrothebaine and bractazonine, two dibenz[d,f]azonine alkaloids of Papaver bracteatumQ104388371
The structure elucidation of Rhazinilam, a new class of Alkaloids from the apocynaceae, by X-ray analysisQ104395707
Sophoraside A, a new aromatic glycoside from the roots of Sophora japonica.Q104921514
Two novel aromatic compounds from Caesalpinia sappan.Q104996037
Novel sesquiterpene from bioactive fractions of cultivar sunflowersQ105003593
P433issue1
P921main subjectbiomimeticsQ1145644
P304page(s)21-29
P577publication date2012-11-18
P1433published inNature Chemical BiologyQ904026
P1476titleBiomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion
P478volume9

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cites work (P2860)
Q58580325A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion
Q36093023A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles
Q38798602A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity
Q90093163A Scaffold-Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides
Q36207545A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine
Q64992798A divergent synthetic pathway for pyrimidine-embedded medium-sized azacycles through an N-quaternizing strategy.
Q55334009A diversity-oriented synthesis of bioactive benzanilides via a regioselective C(sp2)-H hydroxylation strategy.
Q93133678A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
Q34993742A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling
Q41898587A tandem isomerization/prins strategy: iridium(III)/Brønsted acid cooperative catalysis
Q51766245Biogenetically inspired synthesis and skeletal diversification of indole alkaloids.
Q41107892Capture-Collapse Heterocyclization: 1,3-Diazepanes by C-N Reductive Elimination from Rhodacyclopentanones
Q52590901Chemical probes and drug leads from advances in synthetic planning and methodology.
Q36167128Cheminformatic comparison of approved drugs from natural product versus synthetic origins
Q48273532Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5+4] Cycloaddition.
Q35166727Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands
Q28817632Diversity-Oriented Synthesis of Natural-Product-like Libraries Containing a 3-Methylbenzofuran Moiety for the Discovery of New Chemical Elicitors
Q35278303Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy
Q28821081Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction
Q47106457Impact of the structures of macrocyclic Michael acceptors on covalent proteasome inhibition.
Q61881614Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Q48149873Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas
Q51660636Metal-free tandem oxidative C(sp(3))-H bond functionalization of alkanes and dearomatization of N-phenyl-cinnamamides: access to alkylated 1-azaspiro[4.5]decanes.
Q37091004Modular, One-Pot, Sequential Aziridine Ring Opening-S(N)Ar Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams
Q48370410Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles
Q55535124Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data of new compounds. CCDC 1430515. For ESI and crystallographic d
Q35548736Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries
Q36231032Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings
Q51743864Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings.
Q30490492Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties
Q39179647Ring-Expansion Reactions in the Synthesis of Macrocycles and Medium-Sized Rings
Q53085414Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation.
Q38918833Seven-membered rings through metal-free rearrangement mediated by hypervalent iodine.
Q48100654Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion.
Q89220527Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction
Q48103688Synthesis of Cyclic Peptide Mimetics by the Successive Ring Expansion of Lactams.
Q43762423Total Synthesis of Terpenoids Employing a "Benzannulation of Carvone" Strategy: Synthesis of (-)-Crotogoudin.
Q48144026Traceless Solid-Phase Synthesis of Fused Chiral Macrocycles via Conformational Constraint-Assisted Cyclic Iminium Formation.
Q50576686Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings.

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