The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent

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The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1517/13543784.10.7.1243
P8608Fatcat IDrelease_dcxlch2r4jhn7przxzjplkx2xq
P698PubMed publication ID11772248

P2093author name stringSteer CJ
Rodrigues CM
P2860cites workIdentification of a nuclear receptor for bile acidsQ22010058
Bile acids: natural ligands for an orphan nuclear receptorQ22010063
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityQ24630723
Structure of Bax: coregulation of dimer formation and intracellular localizationQ27628839
A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study GroupQ28243457
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activityQ28354314
Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formationQ28373562
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformationsQ28506809
Caspases: enemies withinQ29547315
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Bcl-2 functions in an antioxidant pathway to prevent apoptosisQ29620401
Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosisQ30890236
Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytesQ32075927
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transitionQ32075959
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.Q33834255
Mitochondrial membrane perturbations in cholestasis.Q33836633
Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasisQ33910573
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.Q34732527
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?Q35254212
Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytesQ35824326
Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosisQ36288387
Mechanisms and regulation of bile secretionQ37253872
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbationQ37383640
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosisQ38326924
Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosisQ40883127
Catabolites of cholesterol synthesis pathways and forskolin as activators of the farnesoid X-activated nuclear receptorQ40897197
Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytesQ41082336
The proto-oncogene Bcl-2 and its role in regulating apoptosisQ41492030
Double identity for proteins of the Bcl-2 familyQ41508318
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen speciesQ41513775
Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acidsQ41668171
Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot studyQ41916901
Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: role of the cytoskeletonQ42496447
Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liverQ42797129
Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding.Q43575682
Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosisQ44772320
Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's diseaseQ45291692
Hepatic injury induced by bile salts: correlation between biochemical and morphological eventsQ46245057
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)1243-1253
P577publication date2001-07-01
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleThe therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent
P478volume10

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cites work (P2860)
Q44982548A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation
Q40429203Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition
Q42610890Death pathways associated with photodynamic therapy
Q57113939High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice
Q48405759Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups
Q55020611N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models.
Q35669694Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain
Q38628470Obeticholic acid for the treatment of primary biliary cirrhosis
Q35730907Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial
Q90456286Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function
Q89690610Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease-A Pilot Study
Q37367051Quantitative Identification of Compound-Dependent On-Modules and Differential Allosteric Modules From Homologous Ischemic Networks
Q36972534Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records
Q37257418Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis
Q34075502Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.
Q55260793The role of bile acids in cellular invasiveness of gastric cancer.
Q38946483Ursodeoxycholic acid decreases bilirubin-induced osteoblast apoptosis
Q39658125Ursodeoxycholic acid inhibits TNFα-induced IL-8 release from monocytes
Q51373827Ursodeoxycholic acid treatment of hepatic steatosis: a (13)C NMR metabolic study.

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