High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice

scholarly article by Grant Norman et al published August 2018 in Antimicrobial Agents and Chemotherapy

High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.00222-18
P932PMC publication ID6105847
P698PubMed publication ID29784843

P50authorValerie L SimQ57578937
P2093author name stringGrant Norman
Jody Campeau
P2860cites workNuclear DNA fragmentation in Creutzfeldt-Jakob disease: does a mere positive in situ nuclear end-labeling indicate apoptosis?Q48292509
Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice.Q48496803
TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice.Q48603223
Abnormal synaptic protein expression and cell death in murine scrapie.Q48605040
Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease.Q54498834
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[Cytotoxicity of bile acids on cultured cells (author's transl)]Q71272461
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Bile acids: regulation of apoptosis by ursodeoxycholic acidQ24653969
Formation of native prions from minimal components in vitroQ24676353
Measurement of protein using bicinchoninic acidQ26778491
Bile Acids in Neurodegenerative DisordersQ28078549
The enzymes, regulation, and genetics of bile acid synthesisQ28204726
Irreversible inhibitors of serine, cysteine, and threonine proteasesQ28217093
Efficacy and Specificity of Chenodeoxycholic Acid Therapy for Dissolving GallstonesQ28243178
A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study GroupQ28243457
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.Q33896722
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.Q34075502
In vitro generation of infectious scrapie prions.Q34413661
The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agentQ34481547
Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathwayQ34520873
Synaptic pathology and cell death in the cerebellum in Creutzfeldt-Jakob diseaseQ35184541
Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in miceQ35231059
Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trialQ35730907
Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.Q35861134
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.Q36334348
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease.Q37064641
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Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosisQ37257418
Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion proteinQ37526157
Bile salts in control of lipid metabolismQ38794385
Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation.Q38973518
Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cellsQ39426414
Bile acids, liver injury, and liver diseaseQ39956246
Potential role of ursodeoxycholic acid in suppression of nuclear factor kappa B in microglial cell line (BV-2).Q40506330
Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids.Q41341706
Effects of bile salts on the plasma membranes of isolated rat hepatocytesQ41900837
Safety, tolerability, and cerebrospinal fluid penetration of ursodeoxycholic Acid in patients with amyotrophic lateral sclerosis.Q43236433
A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.Q43748609
The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.Q44931390
Effect of transition metals (Mn, Cu, Fe) and deoxycholic acid (DA) on the conversion of PrPC to PrPresQ46367797
Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucoseQ46518646
The sequential development of the brain lesion of scrapie in three strains of miceQ47696105
P4510describes a project that usesImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
infectious diseaseQ18123741
P577publication date2018-08-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleHigh Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice
P478volume62

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