Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis

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Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI108191
P932PMC publication ID301978
P698PubMed publication ID171281

P50authorGerald WeissmannQ21064035
P2093author name stringWeissmann G
Goldstein IM
Roos D
Kaplan HB
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 gQ26778365
Superoxide dismutase activity in leukocytesQ30501339
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.Q34460377
Interaction of immunoglobulins with liposomes.Q34461870
Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous diseaseQ34463336
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytesQ34480543
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agentQ34501431
Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytesQ34519261
Mechanisms of lysosomal enzyme release from human leukocytes: microtubule assembly and membrane fusion induced by a component of complementQ34739161
Cytochalasin B: effect on lysosomal enzyme release from human leukocytesQ35099034
Studies on lysosomes. XI. Characterization of a hydrolase-rich fraction from human lymphocytesQ36189526
Receptors for complement of leukocytesQ36269375
Superoxide production by phagocytic leukocytesQ36360160
Microfilaments in Cellular and Developmental ProcessesQ36562251
Cytochalasin B reversibly inhibits phagocytosis: functional, metabolic, and ultrastructural effects in human blood leukocytes and rabbit alveolar macrophagesQ36991610
Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytesQ39918646
Superoxide dismutases in polymorphonuclear leukocytesQ40368689
Receptors for human gamma G globulin on human neutrophils.Q40475365
Selective labilization of specific granules in polymorphonuclear leukocytes by phorbol myristate acetateQ41767461
Formation of C3a and C5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivatorQ42836210
Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytesQ44323452
Role of the superoxide anion in the myeloperoxidase-mediated antimicrobial systemQ44736639
The adherence of leucocytes and platelets induced by fixed IgG antibody or complementQ46948382
Effect of specific antibodies on the metabolism of guinea pig polymorphonuclear leukocytesQ46989645
Cytochalasin B III. Inhibition of Human Polymorphonuclear Leukocyte PhagocytosisQ47752389
The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclassesQ54160061
Enhancement of nitroblue tetrazolium dye reduction by leukocytes exposed to a component of complement in the absence of phagocytosisQ57731385
Lysosomal enzyme release from human leukocytes: mediation by the alternate pathway of complement activationQ57731403
Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particlesQ57731425
Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidaseQ66892203
Defective superoxide production by granulocytes from patients with chronic granulomatous diseaseQ68677311
Polymorphonuclear leukocyte activation: effects of phospholipase CQ68765599
Singlet excited oxygen as a mediator of the antibacterial action of leukocytesQ68795673
The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytesQ68807575
Cytochalasin B: Effects on Microfilaments and Movement of Melanin Granules within MelanocytesQ69089916
The visualization of receptors for the Fc portion of the IgG molecule on human neutrophil leukocytesQ69370761
Specific degranulation of human polymorphonuclear leukocytesQ69746944
An abnormality of the alternate pathway of complement activation in sickle-cell diseaseQ70034822
Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activityQ70040485
Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysisQ70439654
The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particlesQ70601767
Influence of Type of Ingested Particle on Human Leukocyte MetabolismQ70649962
Carbohydte metabolism in leukocytes. XI. Stimulation of eosinophils and neutrophilsQ71231325
Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serumQ74220656
A PREPARATIVE METHOD FOR THE SEPARATION OF 7S GAMMA GLOBULIN FROM HUMAN SERUMQ77143636
The extinction coefficient of cytochrome cQ79394921
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectphagocytosisQ184726
P304page(s)1155-1163
P577publication date1975-11-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleComplement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis
P478volume56

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Q70895392Protection of human neutrophils against oxidative damage
Q34614450Pulmonary response of fifth component of complement-sufficient and -deficient mice to hyperoxia
Q69751125Purification of eosinophils from normal human blood, preparation of eosinoplasts and characterization of their functional response to various stimuli
Q34409023Quantitative granulocyte chemiluminescence in the rapid detection of impaired opsonization of Escherichia coli
Q36348317Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipoxygenase activity
Q77900065Reactive oxygen species are required for the phagocytosis of myelin by macrophages
Q46303593Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase
Q38160013Redox-sensitive probes for the measurement of redox chemistries within phagosomes of macrophages and dendritic cells
Q39781875Regulation of polymorphonuclear cell activation by thrombopoietin
Q67848408Release of azurophilic granule contents in fMLP-stimulated neutrophils requires two activation signals, one of which is a rise in cytosolic free Ca2+
Q40689472Requirement of extracellular complement and immunoglobulin for intracellular killing of micro-organisms by human monocytes
Q36901886Respective Influence of Uremia and Hemodialysis on Whole Blood Phagocyte Oxidative Metabolism, and Circulating Interleukin-1 and Tumor Necrosis Factor
Q72858801Reversal of an abnormality of polymorphonuclear leukocyte chemotaxis with lithium
Q44608167Rheumatoid arthritis synovial fluid phospholipase A2 activating protein (PLAP) stimulates human neutrophil degranulation and superoxide ion production
Q68463491Rheumatoid factor modulation of neutrophil superoxide generation enhancing activity of preformed immune complexes
Q36343825Role of activated macrophages in antibody-dependent lysis of tumor cells
Q40166867Role of anti-pilus antibodies in host defense against gonococcal infection studied with monoclonal anti-pilus antibodies
Q33901270Role of antibody and complement in the control of Encephalitozoon cuniculi infections by rabbit macrophages.
Q36405086Role of arachidonic acid in stimulation of hexose transport by human polymorphonuclear leukocytes
Q28366265Role of cell surface contact in the kinetics of superoxide production by granulocytes
Q40184513Role of oxygen radicals in tumor promotion
Q42101310Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions
Q38682345Role of reactive oxygen metabolites in experimental glomerular disease
Q40921675Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation
Q40279189Sendai virus stimulates chemiluminescence in mouse spleen cells
Q57754069Serum Antioxidant Activity and Related Variables in Rheumatoid Arthritis:Behaviour during Sulphydrylant Treatment
Q70159221Serum Factors from Patients with Systemic Lupus Erythematosus Enhancing Superoxide Generation by Normal Neutrophils
Q33643267Serum complement component depression during acute adenovirus conjunctivitis
Q36349824Serum factor requirement for reactive oxygen intermediate release by rabbit alveolar macrophages
Q72919151Some effects of copper deficiency on leucocyte function in sheep and cattle
Q40215148Specific antibody-dependent activation of neutrophils by liposomes containing spin-label lipid haptens
Q70979749Stimulation by oxygen radicals of prostaglandin production by rat renal glomeruli
Q43203796Stimulation of neutrophil functions by C5a(desArg): an in vitro model of haemodialysis
Q64225677Stimulation of neutrophil oxidative metabolism by indomethacin
Q57731240Stimulus-response coupling in the human neutrophil. The role of anion fluxes in degranulation
Q46913652Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice
Q33556342Studies of the effect of D-penicillamine and sodium aurothiomalate therapy on superoxide anion production by monocytes from patients with rheumatoid arthritis: evidence for in vivo stimulation of monocytes
Q72667284Studies on the mechanism of PMN activation II. by triggering the alternative pathway of complement activation
Q70717765Study of phagocytic function with a quantitative nitroblue-Tetrazolium (NBT) reduction test in diabetes mellitus
Q42936183Subcellular localization of NAD(P)H oxidase(s) in human neutrophilic polymorphonuclear leucocytes
Q34526448Subnormal activation of phagocytes by complement in chronic inflammatory bowel disease? Neutrophil chemotaxis to complement split product C5a.
Q33556024Subnormal sensitivity of neutrophils to complement split product C5a in rheumatoid arthritis: relation to complement catabolism and disease extent
Q68458440Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis
Q39564943Superoxide dismutase for therapeutic use: clinical experience, dead ends and hopes
Q70147088Superoxide generation by synovial fluid neutrophils enhanced by immune complexes and suppressed by rheumatoid factor in synovial fluid
Q35905530Superoxide production and reducing activity in human platelets
Q40183842Superoxide production from human polymorphonuclear leucocytes stimulated with immunoglobulins of different classes and fragments of IgG bound to polystyrene dishes
Q28322416Superoxide production induced in rabbit polymorphonuclear leukocytes by synthetic chemotactic peptides and A23187
Q70180277Superoxide radical production by human leukocytes exposed to immune complexes: inhibitory action of gold compounds
Q72945106Superoxide-dismutase and superoxide-radical-release in rheumatoid arthritis (author's transl)
Q36982442Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen
Q40152532Termination of the Respiratory Burst in Human Neutrophils
Q70308289The Early Effect of Sublethal X-irradiation of Phagocytic Cells in Mouse Blood and the Influence of Cystamine as Measured by Chemiluminescence
Q41013253The Interaction of Opsonins with Human Polymorphonuclear Leucocytes (PMN). I. The Influence of Human Complement (C) and IgG on Ingestion and Digestion of C-Resistant E. coli
Q72934682The Respiratory Burst in Human Polymorphonuclear Leucocytes Stimulated by Particles
Q34248005The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively
Q46793939The antiinflammatory action of some compounds with antioxidant properties
Q73639434The bactericidal/permeability-increasing protein (BPI) is membrane-associated in azurophil granules of human neutrophils, and relocation occurs upon cellular activation
Q72587927The effect of a sulfonated shale oil extract (ichthyol) on the migration of human neutrophilic granulocytes in vitro
Q41725659The effect of oxidant stress on diamide-treated human granulocytes
Q69048026The effect of paraquat lung on mononuclear cells
Q28321730The effect of tobacco smoke on the metabolism and function of rat alveolar macrophages
Q41553207The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils
Q72905757The effects of an ECF-A and formyl methionyl chemotactic peptides on oxidative metabolism of human eosinophils and neutrophils
Q28362314The impact of platelet-activating factor (PAF)-like mediators on the functional activity of neutrophils: anti-inflammatory effects of human PAF-acetylhydrolase
Q42855181The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites.
Q43650427The mechanisms of serum-treated zymosan (STZ)-induced oxidative metabolism by human eosinophils and the effects of IL-5 priming
Q40133688The metabolism of superoxide anion and its progeny in blood cells
Q70908919The onset of polymorphonuclear leucocyte membrane-stimulated metabolic activity
Q68356565The oxidant defence system in water-buffaloes (Babalus bubalis) experimentally infected with Anaplasma marginate
Q39113498The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst
Q40125845The release of inflammatory mediators from neutrophils
Q40236100The release of superoxide anion from granulocytes: Effect of inhibitors of anion permeability
Q39990758The requirement for membrane sialic acid in the stimulation of superoxide production during phagocytosis by human polymorphonuclear leukocytes
Q34307796The respiratory burst response of surface-adhering leukocytes. A key to tissue engineering
Q40788655The role of Fc and C3b receptors in phagocytosis by inflammatory polymorphonuclear leucocytes in man
Q38760961The role of neutrophils in vascular injury: a summary of signal transduction mechanisms in cell/cell interactions
Q46738965The stimulation of superoxide anion production in guinea-pig peritoneal macrophages and neutrophils by phorbol myristate acetate, opsonized zymosan and IgG2-containing soluble immune complexes
Q41142664The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture
Q36341902Thromboxane generation by human peripheral blood polymorphonuclear leukocytes
Q34562547Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins
Q44466421Triphenyltin enhances the neutrophilic differentiation of promyelocytic HL-60 cells
Q42865937Two distinct mechanisms for stimulation of oxygen-radical production by polymorphonuclear leucocytes
Q28619111Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate
Q43546849U73122 inhibits the dephosphorylation and translocation of cofilin in activated macrophage-like U937 cells
Q40252872Unique characteristics of superoxide production by human eosinophils in eosinophilic states
Q34559309Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation
Q37943861What's new in the role of complement in diseases?
Q71486034[Oxidative metabolism of phagocytes: physicochemical events and clinical relevance (author's transl)]

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