The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation

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The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1033788Z
P356DOI10.1371/JOURNAL.PONE.0133788
P932PMC publication ID4517749
P698PubMed publication ID26218273
P5875ResearchGate publication ID281818604

P2093author name stringYu Zhang
Ying Zhang
Jun Ma
Bin Zhou
Jijie Chai
Qian Cao
Renbin Zhao
Wenqing Zhao
Meizi Zhang
Feima Guo
P2860cites workThe FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamilyQ21284385
Inhibition of adipogenesis by Wnt signalingQ22254771
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTOQ24293481
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseQ24299948
Crystal structure of the FTO protein reveals basis for its substrate specificityQ24306184
FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes.Q50920947
Isolation and characterization of N6-methyladenosine from Escherichia coli valine transfer RNAQ69890886
Methylated bases of ribosomal ribonucleic acid from HeLa cellsQ72091149
Overexpression of Fto leads to increased food intake and results in obesityQ34479211
Emerging function of fat mass and obesity-associated protein (fto)Q34539946
Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restrictionQ35016956
The methylation state of poly A-containing-messenger RNA from cultured hamster cellsQ36213266
Role for the obesity-related FTO gene in the cellular sensing of amino acidsQ36617006
New developments in adipogenesisQ37408916
Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiationQ38559878
FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liverQ39035680
Methylated nucleotides block 5' terminus of HeLa cell messenger RNA.Q39923664
Sequence specificity of internal methylation in B77 avian sarcoma virus RNA subunitsQ40046945
Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis.Q40638066
Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonistsQ42815154
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Distinct transcriptional profiles of adipogenesis in vivo and in vitroQ42827325
Wnt10b inhibits development of white and brown adipose tissuesQ47364038
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOQ24310886
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seqQ24320240
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cellsQ24563918
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codonsQ24598126
Mapping of N6-methyladenosine residues in bovine prolactin mRNAQ24607526
Hypothalamic FTO is associated with the regulation of energy intake not feeding rewardQ24643901
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityQ24650037
Adult onset global loss of the fto gene alters body composition and metabolism in the mouseQ27325807
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminusQ28202411
Inactivation of the Fto gene protects from obesityQ28235948
Localization of N6-methyladenosine in the Rous sarcoma virus genomeQ28252257
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentQ28255124
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brainQ28265784
Variation in FTO contributes to childhood obesity and severe adult obesityQ28301922
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO geneQ28475923
Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiationQ28573850
ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesisQ28588161
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsQ29547210
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traitsQ29614593
Adipose tissue as an endocrine organQ29620407
Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophyQ31137907
Analysis of gene expression data using BRB-ArrayTools.Q33448521
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.Q33526368
Regulation of Fto/Ftm gene expression in mice and humansQ33599999
Changes in gene expression associated with FTO overexpression in miceQ33632126
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in miceQ33754711
Transcriptional regulation of adipogenesisQ33932631
FTO is expressed in neurones throughout the brain and its expression is unaltered by fastingQ34091174
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitryQ34354815
A link between FTO, ghrelin, and impaired brain food-cue responsivityQ34358429
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesisQ34448805
FTO influences adipogenesis by regulating mitotic clonal expansionQ34472171
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)e0133788
P577publication date2015-07-28
P1433published inPLOS OneQ564954
P1476titleThe Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation
P478volume10

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cites work (P2860)
Q33717771Complex Relationship between Obesity and the Fat Mass and Obesity Locus
Q39378718Dynamic RNA Modifications in Gene Expression Regulation
Q64087596Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival
Q89939453FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation
Q38924991FTO Promotes Adipogenesis through Inhibition of the Wnt/β-catenin Signaling Pathway in Porcine Intramuscular Preadipocytes
Q37745383FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis
Q89206393FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications
Q36867329Hypomorphism of Fto and Rpgrip1l causes obesity in mice
Q36001686Increased Circulating Levels of Alpha-Ketoglutarate in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease
Q33630322Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
Q36847093Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice
Q98196771Intracellular and tissue specific expression of FTO protein in pig: changes with age, energy intake and metabolic status
Q36393233Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases
Q37210186Mouse Maternal High-Fat Intake Dynamically Programmed mRNA m⁶A Modifications in Adipose and Skeletal Muscle Tissues in Offspring
Q47128487N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing
Q34504400N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.
Q36306222Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
Q37515917Post-transcriptional gene regulation by mRNA modifications.
Q93089064RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases
Q93051746Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis
Q26770844Role of FTO in Adipocyte Development and Function: Recent Insights
Q36633354The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro
Q92756545The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage
Q58100109The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys
Q90315314The partial inhibition of hypothalamic IRX3 exacerbates obesity
Q35952914Tissue Distribution of Porcine FTO and Its Effect on Porcine Intramuscular Preadipocytes Proliferation and Differentiation

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