Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation

scientific article published on 12 July 2008

Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2008.07.003
P932PMC publication ID3179914
P698PubMed publication ID18674534
P5875ResearchGate publication ID23143876

P50authorKurt D. HankensonQ38544088
P2093author name stringMichael Friedman
Joshua Miller
Ormond A Macdougald
Weijun Luo
Hailu Shitaye
Christina N Bennett
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Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?Q33983147
Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolismQ34284209
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitorsQ34546901
Building a consensus regarding the nature and origin of mesenchymal stem cells.Q34669038
Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis.Q35586371
B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.Q36094900
RGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activitiesQ36222698
Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytesQ36324476
The effects of heparin and low molecular weight heparins on boneQ36918327
Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturationQ38321083
Production of heparan sulphate proteoglycans by human bone marrow stromal cellsQ38335492
In vivo development and long-term survival of engineered adipose tissue depend on in vitro precultivation strategyQ40114723
Changes in integrin expression during adipocyte differentiationQ40375216
Low doses and high doses of heparin have different effects on osteoblast-like Saos-2 cells in vitroQ40575533
Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2.Q40941050
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis.Q41056796
Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O.Q42818414
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytesQ42825227
Antibodies against a putative heparin receptor slow cell proliferation and decrease MAPK activation in vascular smooth muscle cellsQ43586666
Heparan sulfate is necessary for adhesive interactions between human early hemopoietic progenitor cells and the extracellular matrix of the marrow microenvironmentQ43761039
A histomorphometric comparison of the effects of heparin and low-molecular-weight heparin on cancellous bone in ratsQ47310175
Syndecans: synergistic activators of cell adhesionQ47721351
'Heparin'--from anticoagulant drug into the new biologyQ48773643
Sulfated polysaccharides enhance the biological activities of bone morphogenetic proteins.Q51837891
The role of C/EBP genes in adipocyte differentiation.Q52182559
The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation.Q52545449
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferationQ54246457
Binding of primitive hematopoietic progenitor cells to marrow stromal cells involves heparan sulfateQ68009734
Effects of low molecular weight heparin and unfragmented heparin on induction of osteoporosis in ratsQ68478325
Inhibition of human osteoblast growth by unfractionated heparin and by low molecular weight heparins in vitroQ74658422
Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosisQ77171441
Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfateQ77388260
Fibronectin peptides derived from two distinct regions stimulate adipocyte differentiation by preventing fibronectin matrix assemblyQ77684724
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gammaQ79918319
Differential effects of heparin and low molecular weight heparin on osteoblastogenesis and adipogenesis in vitroQ80828018
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectheparinQ190016
adipocyteQ357519
P304page(s)3382-3391
P577publication date2008-07-12
P1433published inExperimental Cell ResearchQ1524289
P1476titleDisruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation
P478volume314

Reverse relations

cites work (P2860)
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Q38022259Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways
Q38882445Evolution of the Marrow Adipose Tissue Microenvironment
Q57112936Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages
Q51832744Heparin-induced conformational changes of fibronectin within the extracellular matrix promote hMSC osteogenic differentiation.
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Q38558581Opportunities and challenges in three-dimensional brown adipogenesis of stem cells
Q58676364Presentation of functional groups on self-assembled supramolecular peptide nanofibers mimicking glycosaminoglycans for directed mesenchymal stem cell differentiation
Q35612306RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation
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Q34405389Synovial fluid progenitors expressing CD90+ from normal but not osteoarthritic joints undergo chondrogenic differentiation without micro-mass culture
Q34487238The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation
Q42745379The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition
Q34127148Thrombospondin-2 is an endogenous adipocyte inhibitor.

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