Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma

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Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...748694S
P356DOI10.1371/JOURNAL.PONE.0048694
P932PMC publication ID3501495
P698PubMed publication ID23185271
P5875ResearchGate publication ID233775443

P50authorMarcus StåhlmanQ40879155
Jan BorénQ42048764
P2093author name stringPaolo Parini
Martin E Johansson
Annika Lundqvist
Jeanna Perman Sundelin
Max Levin
P2860cites workRabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificityQ24293268
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liverQ24305507
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Cancer statistics, 2010Q27860525
Isolation and characterization of progenitor-like cells from human renal proximal tubulesQ34760590
Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implicationsQ35137857
Automated Identification and Quantification of Glycerophospholipid Molecular Species by Multiple Precursor Ion ScanningQ57364873
Low density lipoprotein-receptor activity is lost in vivo in malignantly transformed renal tissueQ57636156
Origin of intracellular cholesterol in renal-cell carcinomaQ66694987
Effects of hypoxia on sterol synthesis, acyl-CoA:cholesterol acyltransferase activity, and efflux of cholesterol in cultured rabbit skin fibroblastsQ68697098
Abnormal cholesterol metabolism in renal clear cell carcinomaQ69449106
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarctionQ35572373
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycanQ37317424
Review article: How cells sense oxygen: lessons from and for the kidneyQ37368447
VHL and HIF signalling in renal cell carcinogenesisQ37708208
Tumor biology and prognostic factors in renal cell carcinomaQ37846387
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cellsQ39500622
Comparative light and electron microscopic observations of the cytoplasmic matrix in renal carcinomasQ43532808
High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS).Q46928125
Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulationQ47928192
The quantitative role of the kidneys in the in vivo metabolism of mevalonateQ48319267
Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection.Q48435318
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
P304page(s)e48694
P577publication date2012-11-19
P1433published inPLOS OneQ564954
P1476titleIncreased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma
P478volume7

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cites work (P2860)
Q42928626Constitutive expression of HIF-α plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma
Q92544560Fatty acids - from energy substrates to key regulators of cell survival, proliferation and effector function
Q101133417Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells
Q89361082Genetic and metabolic hallmarks of clear cell renal cell carcinoma
Q64075768High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma
Q58692616Lipid Droplets in Cancer: Guardians of Fat in a Stressful World
Q28078259Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia
Q92610667Lipid droplets can promote drug accumulation and activation
Q37054261Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma
Q37584289Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma
Q88144021Lysosomal acid lipase promotes cholesterol ester metabolism and drives clear cell renal cell carcinoma progression
Q37383236Molecular pathways: sterols and receptor signaling in cancer
Q35995926PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma
Q58770461Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma
Q58764584Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation
Q49554294Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma.

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