Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression

scientific article

Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.5145
P932PMC publication ID4741613
P698PubMed publication ID26384300
P5875ResearchGate publication ID281971291

P50authorKlaudia SkrzypekQ59696744
Anna KusienickaQ88584466
Marcin MajkaQ88841239
P2093author name stringEwa Lukasiewicz
Katarzyna Miekus
Tomasz Adamus
Barbara Szewczyk
P2860cites workMiRNA-directed regulation of VEGF and other angiogenic factors under hypoxiaQ21092263
Gelatinase B/MMP-9 in Tumour Pathogenesis and ProgressionQ24568374
MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma developmentQ24648202
MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expressionQ24683830
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneQ28202069
Met, metastasis, motility and moreQ28235183
Targeting the c-Met signaling pathway in cancerQ28246393
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
Wnt activity defines colon cancer stem cells and is regulated by the microenvironmentQ29618024
MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiationQ30426550
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation.Q30486161
The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiationQ30534479
Efficient myoblast expansion for regenerative medicine useQ33811402
shRNA-mediated decreases in c-Met levels affect the differentiation potential of human mesenchymal stem cells and reduce their capacity for tissue repairQ34163289
Building muscle: molecular regulation of myogenesis.Q34251533
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinaseQ34358610
Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiationQ34442918
Conditional activation of MET in differentiated skeletal muscle induces atrophy.Q34595811
Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family membersQ34894993
The melanocyte differentiation program predisposes to metastasis after neoplastic transformationQ35216430
MET receptor is a potential therapeutic target in high grade cervical cancerQ35832923
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesionQ35875566
Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factorQ35961109
MET is required for the recruitment of anti-tumoural neutrophilsQ36125652
Cancer therapy: can the challenge be MET?Q36159458
Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells.Q36388832
Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomasQ36409237
From Tpr-Met to Met, tumorigenesis and tubes.Q36745364
The biological role of HGF-MET axis in tumor growth and development of metastasisQ36992086
Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasisQ37087420
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiationQ37286651
Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?Q37325228
Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumorsQ37356573
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.Q37598845
Tumor-associated neutrophils: new targets for cancer therapyQ37856086
Modeling sarcomagenesis using multipotent mesenchymal stem cellsQ37935534
Targeting MET in cancer: rationale and progressQ37978193
Hypoxia control to normalize pathologic angiogenesis: potential role for endothelial precursor cells and miRNAs regulationQ37996791
MicroRNAs and epigenetic mechanisms of rhabdomyosarcoma developmentQ38212020
C-Met pathway promotes self-renewal and tumorigenecity of head and neck squamous cell carcinoma stem-like cellQ38212355
Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survivalQ38441644
The strategy of fusion genes construction determines efficient expression of introduced transcription factorsQ38960590
miRNA expression profile in human osteosarcoma: role of miR-1 and miR-133b in proliferation and cell cycle control.Q39228419
Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypesQ39561634
Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformationQ39606702
Inhibition of rhabdomyosarcoma's metastatic behavior through downregulation of MET receptor signalingQ39738155
Clinical significance of CXC chemokine receptor-4 and c-Met in childhood rhabdomyosarcomaQ39966371
Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cellsQ41109580
Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse developmentQ42770153
Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma.Q42802665
Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator-activated receptor γ.Q42819239
A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiationQ42821276
Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.Q43045056
c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases.Q46265281
Genetically modified adipose tissue-derived mesenchymal stem cells overexpressing CXCR4 display increased motility, invasiveness, and homing to bone marrow of NOD/SCID mice.Q50524510
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.Q52547784
The MET oncogene is a functional marker of a glioblastoma stem cell subtype.Q55462084
Rhabdomyosarcoma spheroids with central proliferation and differentiationQ67720758
HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cellsQ74213837
Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutationsQ81780679
c-Met is a marker of pancreatic cancer stem cells and therapeutic targetQ84816959
P4510describes a project that usesImageJQ1659584
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectrhabdomyosarcomaQ1898141
P304page(s)31378-31398
P577publication date2015-09-08
P1433published inOncotargetQ1573155
P1476titleConstitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression
P478volume6

Reverse relations

cites work (P2860)
Q64060174C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas
Q48235688Caffeic Acid and Metformin Inhibit Invasive Phenotype Induced by TGF-β1 in C-4I and HTB-35/SiHa Human Cervical Squamous Carcinoma Cells by Acting on Different Molecular Targets
Q38763225Identification of clinically achievable combination therapies in childhood rhabdomyosarcoma
Q92600008MET promotes the proliferation and differentiation of myoblasts
Q95388147Rhabdomyosarcoma
Q55041016SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function.
Q50422607SPRY2 is a novel MET interactor that regulates metastatic potential and differentiation in rhabdomyosarcoma.
Q26770132The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
Q36194212Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion.

Search more.