Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells

scientific article published on May 1997

Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1034947739
P356DOI10.1038/SJ.ONC.1201083
P698PubMed publication ID9188856
P5875ResearchGate publication ID14029928

P50authorPaolo M. ComoglioQ37381902
P2093author name stringBond JA
Prat M
Wynford-Thomas D
Ivan M
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)2417-2423
P577publication date1997-05-01
P1433published inOncogeneQ1568657
P1476titleActivated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells
P478volume14

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cites work (P2860)
Q3792036015-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy
Q82905603A case study of metastatic Xp11.2 translocation renal cell carcinoma effectively treated with sunitinib
Q24546366Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
Q57796537Activation of KRAS mediates resistance to targeted therapy in MET ex on 14 mutant non-small cell lung cancer
Q36822111Activity of XL184 (Cabozantinib), an Oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid Cancer
Q43652201Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice
Q24633986An overview of the c-MET signaling pathway
Q33693109Antisense--time to shoot the messenger
Q38771978C-Met as a potential target for the treatment of gastrointestinal cancer: Current status and future perspectives.
Q38125434Cell-Autonomous and Non–Cell-Autonomous Mechanisms of HGF/MET–Driven Resistance to Targeted Therapies: From Basic Research to a Clinical Perspective
Q41251561Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma
Q84584265Clinical significance of serum hepatocyte growth factor and epidermal growth factor gene somatic mutations in patients with non-squamous non-small cell lung cancer receiving gefitinib or erlotinib
Q34494731Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression
Q54660009Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma.
Q83903141Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin
Q37175416Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis
Q34782774Drug development of MET inhibitors: targeting oncogene addiction and expedience
Q36323379GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase
Q47833619Genetic alterations in human epithelial thyroid tumours
Q34303041Genetic markers in thyroid neoplasia
Q39819780HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells
Q37502372INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell models
Q37403891In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer
Q38976616Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence
Q28253680Invasive growth: a MET-driven genetic programme for cancer and stem cells
Q87826971MET amplification is not rare and predicts unfavorable clinical outcomes in patients with recurrent/metastatic gastric cancer after chemotherapy
Q36089948MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome
Q89603062MET targeting: time for a rematch
Q38675350MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy.
Q34085432Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression
Q38683133Medullary Thyroid Cancer: Clinical Characteristics and New Insights into Therapeutic Strategies Targeting Tyrosine Kinases
Q34236194Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: evidence for a pathogenetic role in tumourigenesis
Q28235183Met, metastasis, motility and more
Q39322020MiR-410 regulates MET to influence the proliferation and invasion of glioma
Q61417351MiRNAs in Malignant Melanoma
Q74100664Molecular basis of epithelial thyroid tumorigenesis
Q36299916Molecular classification and biomarker discovery in papillary thyroid carcinoma
Q35094749Molecular pathobiology of thyroid neoplasms
Q35208510Molecular pathogenesis of thyroid cancer
Q44004710Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece
Q33864524New treatment modalities in advanced thyroid cancer
Q43201388Non-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture
Q38846778PEA3 transcription factors are downstream effectors of Met signaling involved in migration and invasiveness of Met-addicted tumor cells.
Q73816410PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS
Q36626127Papillary carcinoma of the thyroid: methylation is not involved in the regulation of MET expression
Q36430189Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Q38782345Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma.
Q46170165Prognostic significance of c-Met expression in glioblastomas
Q39901958RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation
Q47769312RETRACTED: Hepatocyte Growth Factor-Induced Expression of Ornithine Decarboxylase, c-met,and c-mycIs Differently Affected by Protein Kinase Inhibitors in Human Hepatoma Cells HepG2
Q37002770Resistance of papillary thyroid cancer stem cells to chemotherapy
Q45143173Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis.
Q37730020Selection criteria for c-Met-targeted therapies: emerging evidence for biomarkers
Q39385631Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor
Q58164852Silencing the MET oncogene leads to regression of experimental tumors and metastases
Q44283525Study of MET protein levels and MET gene copy number in 72 sinonasal intestinal-type adenocarcinomas
Q33943764Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase
Q37539304Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors
Q37792116Targeting the MET oncogene in cancer and metastases.
Q41954928The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth
Q50977867The Pathogenetic Role of the HGF/c-Met System in Papillary Carcinoma of the Thyroid
Q38824065The Therapeutic Potential of Targeting the HGF/cMET Axis in Ovarian Cancer
Q33922881The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation.
Q55070676[Thirty years of Met receptor research: from the discovery of an oncogene to the development of targeted therapies].
Q38923535c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma