Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function

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Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/STEM.2255
P932PMC publication ID4832316
P698PubMed publication ID26679354

P50authorIlaria BellantuonoQ57414970
Robert Graham G RussellQ67903135
P2093author name stringF Hal Ebetino
Sindhu T Mohanty
James A Fernandes
Juhi Misra
Sanjeev Madan
P2860cites workGamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments.Q53184654
Differentiation-related response to DNA breaks in human mesenchymal stem cellsQ64386387
Frequency of stromal lineage colony forming units in bone marrow of peroxisome proliferator-activated receptor-alpha-null miceQ73315954
Risk of pelvic fractures in older women following pelvic irradiationQ23909178
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth controlQ24314363
mTOR is a key modulator of ageing and age-related diseaseQ24610741
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasisQ24630630
FoxO3 regulates neural stem cell homeostasisQ24658086
Lamin A-dependent nuclear defects in human agingQ24681309
Genomic instability in laminopathy-based premature agingQ28258404
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrestQ28274220
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cellsQ28288970
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironmentQ33701168
Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic indexQ33718131
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy.Q34009569
Bisphosphonates: the first 40 yearsQ34026820
FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or agingQ34197553
Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells.Q34534085
Zoledronic acid and clinical fractures and mortality after hip fractureQ34689802
Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapiesQ34744250
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.Q34790173
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiationQ34986627
Stromal cells and stem cells in clinical bone regenerationQ35116065
A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cellsQ36516974
Functional interaction between FOXO3a and ATM regulates DNA damage responseQ37171572
Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeabilityQ37307982
Potential mediators of the mortality reduction with zoledronic acid after hip fractureQ37542295
Radiation effects on bone healing and reconstruction: interpretation of the literatureQ37685568
Biochemical and molecular mechanisms of action of bisphosphonates.Q37812800
Zoledronic acid use in cancer patients: more than just supportive care?Q37828494
The relationship between the chemistry and biological activity of the bisphosphonates.Q37865849
Charity begins at home: non-coding RNA functions in DNA repairQ38079476
Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trialQ38230839
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathwayQ39458307
Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanismQ39640617
Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation.Q39979667
Irradiated bone and its management.Q40944232
A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID miceQ45112584
Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansionQ45877573
Crif1 Promotes Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells After Irradiation by Modulating the PKA/CREB Signaling PathwayQ46545780
Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells.Q46915466
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
DNA damageQ5205747
P304page(s)756-767
P577publication date2015-12-17
P1433published inStem CellsQ15724411
P1476titleZoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function
P478volume34

Reverse relations

cites work (P2860)
Q41430322Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40.
Q42368059Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells
Q47994742Effect of zoledronate, a third-generation bisphosphonate, on proliferation and apoptosis of human dental pulp stem cells
Q64974351Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.
Q54223105Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
Q28074810Mesenchymal Stem Cells as a Prospective Therapy for the Diabetic Foot
Q52570408Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults.
Q38630699Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation
Q27333060Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts
Q47156108Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis
Q41689098The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

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