The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

scientific article

The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1023979696
P356DOI10.1007/S00125-012-2789-5
P932PMC publication ID3565067
P698PubMed publication ID23232640
P5875ResearchGate publication ID233901138

P2093author name stringZ Xu
H A Toque
M Rojas
R B Caldwell
R W Caldwell
S C Elms
P2860cites workArginine metabolism: nitric oxide and beyondQ24531285
Mouse model for human arginase deficiencyQ24537542
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategiesQ24656109
Arginase-boronic acid complex highlights a physiological role in erectile functionQ27620108
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
Improved leukocyte tracking in mouse retinal and choroidal circulation.Q32109990
Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry studyQ33632944
Flow activates an endothelial potassium channel to release an endogenous nitrovasodilatorQ34209959
Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular systemQ34477324
Vascular oxidative stress: the common link in hypertensive and diabetic vascular diseaseQ34479731
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanismQ34772312
Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathwayQ34979275
Arginase II deletion increases corpora cavernosa relaxation in diabetic miceQ35050926
Endothelial arginase II and atherosclerosisQ35161493
Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathwayQ35708220
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokinesQ35749970
Diabetes-induced vascular dysfunction involves arginase IQ35906453
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophagesQ36244224
Ozagrel attenuates early streptozotocin-induced constriction of arterioles in the mouse retinaQ36646301
Retinal blood flow in diabetesQ36761967
Lack of inducible nitric oxide synthases attenuates leukocyte-endothelial cell interactions in retinal microcirculationQ36940984
Arginase and vascular agingQ36977086
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.Q37278531
Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?Q37483486
Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamineQ39269807
Diabetes-induced coronary vascular dysfunction involves increased arginase activityQ41817278
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistryQ42285845
Attenuation of streptozotocin-induced microvascular changes in the mouse retina with the endothelin receptor A antagonist atrasentanQ42400411
Ischemia‐reperfusion selectively impairs nitric oxide‐ mediated dilation in coronary arterioles: counteracting role of arginaseQ42451488
Vasodilator effects of flunarizine on retinal blood vessels in anesthetized ratsQ43232670
Classical and slow-binding inhibitors of human type II arginaseQ43691595
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthaseQ43952389
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood VesselsQ44601105
Angiotensin AT 1 receptor antagonism normalizes retinal blood flow and acetylcholine-induced vasodiliation in normotensive diabetic ratsQ44656168
Diabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction.Q45086457
Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arteriolesQ45113050
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertensionQ45182794
Hyperglycemia accelerates impairment of vasodilator responses to acetylcholine of retinal blood vessels in rats.Q45981918
C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide productionQ46626730
Rho/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cellsQ46670067
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitorQ48131599
Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transportersQ73316899
Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cellsQ79792606
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)654-662
P577publication date2012-12-12
P1433published inDiabetologiaQ5270140
P1476titleThe role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes
P478volume56

Reverse relations

cites work (P2860)
Q37242111Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles
Q35555144Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability
Q35217395Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function
Q34465434Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration
Q37620647Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism
Q37603245Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury
Q41285088Arginase as a mediator of diabetic retinopathy
Q38082329Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Q34800913Arginase in retinopathy
Q41572196Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs
Q36854784Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats
Q50143099Arginase: A Multifaceted Enzyme Important in Health and Disease.
Q38452432Arginase: an old enzyme with new tricks
Q42113401Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients
Q61797178Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1
Q42123271Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy.
Q39430910Coronary microvascular disease as an early culprit in the pathophysiology of diabetes and metabolic syndrome
Q41384119Effects of the Hydroalcoholic Extract of Zingiber officinale on Arginase I Activity and Expression in the Retina of Streptozotocin-Induced Diabetic Rats
Q38928508Growth Factors in the Pathogenesis of Retinal Neurodegeneration in Diabetes Mellitus
Q91741207HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1
Q48835562Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes
Q46699315Inhibition of TLR4 attenuates vascular dysfunction and oxidative stress in diabetic rats.
Q89598307Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
Q55153776Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.
Q34664336New approaches to the design and discovery of therapies to prevent erectile dysfunction
Q47734746Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.
Q42819649Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.
Q92921921Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity
Q36837617Role of arginase in vessel wall remodeling
Q64071750TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice

Search more.