The core mechanism of dry eye disease is inflammation

scientific article

The core mechanism of dry eye disease is inflammation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1097/ICL.0000000000000042
P932PMC publication ID4231828
P698PubMed publication ID25390549

P50authorPenny AsbellQ43109114
P2093author name stringYi Wei
P2860cites workThe definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Q80347907
Strain-related cytokine profiles on the murine ocular surface in response to desiccating stressQ80382639
Cell populations and adhesion molecules expression in conjunctiva before and after bone marrow transplantationQ81131963
Resolvins as new fascinating drug candidates for inflammatory diseasesQ83381326
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7RαQ83388831
Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic testsQ83419797
Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarraysQ84579952
Exposure to a dry environment induces strain-specific responses in miceQ94520420
sPLA2-IIa amplifies ocular surface inflammation in the experimental dry eye (DE) BALB/c mouse modelQ24635932
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generationQ24683293
Neurturin-Deficient Mice Develop Dry Eye and Keratoconjunctivitis SiccaQ28204835
Tear cytokine profile as a noninvasive biomarker of inflammation for ocular surface diseases: standard operating proceduresQ28393435
Selenium compound protects corneal epithelium against oxidative stressQ28484037
Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in miceQ28730905
Progress and challenges in translating the biology of atherosclerosisQ29619982
Acupuncture for dry eye: a randomised controlled trial protocolQ33552734
Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndromeQ33592784
HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface diseaseQ33861286
Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye diseaseQ33869200
Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathwayQ33938235
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO miceQ34019278
Characterization of effector T cells in dry eye diseaseQ34065949
Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis siccaQ34110644
Oxidative stress induced inflammation initiates functional decline of tear productionQ34446876
IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transferQ34448523
Dry eye as a mucosal autoimmune diseaseQ34647761
Apoptosis as a therapeutic tool in rheumatoid arthritisQ34718143
Topical omega-3 and omega-6 fatty acids for treatment of dry eye.Q34749224
Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity?Q34952967
Interferon-γ-secreting NK cells promote induction of dry eye diseaseQ35001933
Nutritional supplements for dry eye syndromeQ35163639
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndromeQ35674608
Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye diseaseQ35907009
Efficacy of topical blockade of interleukin-1 in experimental dry eye diseaseQ36044544
Toll-like receptor expression and activation in mice with experimental dry eye.Q36159551
An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factorQ36625070
Autoimmunity at the ocular surface: pathogenesis and regulationQ36625074
Tear cytokine profiles in dysfunctional tear syndrome.Q36637791
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice.Q36907644
Dry eye disease: an immune-mediated ocular surface disorderQ36916372
Therapeutic efficacy of topical epigallocatechin gallate in murine dry eye.Q36989668
Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye diseaseQ37013881
Chronic dry eye disease is principally mediated by effector memory Th17 cellsQ37067291
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
Dry eyes: etiology and managementQ37188359
Advances in understanding and managing dry eye diseaseQ37206550
Tearful relations: oxidative stress, inflammation and eye diseasesQ37410898
Rationale for anti-inflammatory therapy in dry eye syndromeQ37410903
Immunoregulation on the ocular surface: 2nd Cullen SymposiumQ37453762
Induction of Th17 differentiation by corneal epithelial-derived cytokinesQ37462911
Essential fatty acids for dry eye: A reviewQ37661830
Essential fatty acids in the treatment of dry eye.Q37682316
sPLA2-IIa is an inflammatory mediator when the ocular surface is compromisedQ37726033
Dry eye disease as an inflammatory disorderQ37756166
IL-6 induction in desiccated corneal epithelium in vitro and in vivo.Q38608898
Effect of hyperosmolality on beta-defensin gene expression by human corneal epithelial cellsQ39242998
Interferon-gamma induces apoptosis and expression of inflammation-related proteins in Chang conjunctival cells.Q40930968
Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice.Q41658848
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study GroupQ41730611
Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13.Q42173370
Role of Th17 cells in the immunopathogenesis of dry eye diseaseQ42694095
A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegansQ43723433
Impaired neurotransmission in lacrimal and salivary glands of a murine model of Sjögren's syndrome.Q44339277
Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surfaceQ45158772
Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2.Q45930063
Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye.Q45950875
Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease.Q46073610
A comparison of vitamin a and cyclosporine a 0.05% eye drops for treatment of dry eye syndromeQ46321286
Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye.Q46466345
The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapyQ46658333
Apoptosis in the lacrimal gland and conjunctiva of dry eye dogsQ47947600
Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium.Q50721017
Increased eotaxin in tears of patients wearing contact lenses.Q51594737
Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome.Q53572321
Isoforms of secretory group two phospholipase A (sPLA2) in mouse ocular surface epithelia and lacrimal glands.Q54316515
Analysis of inflammatory cytokines in the tears of dry eye patients.Q54467014
Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome.Q54602794
Inflammatory Markers in the Tears of Patients with Ocular Surface DiseaseQ58979336
Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis siccaQ72993423
P433issue4
P921main subjectinflammationQ101991
eye diseaseQ3041498
P304page(s)248-256
P577publication date2014-07-01
P1433published inEye and Contact LensQ15765460
P1476titleThe core mechanism of dry eye disease is inflammation
P478volume40

Reverse relations

cites work (P2860)
Q41442733A comparative review of Haute Autorité de Santé and National Institute for Health and Care Excellence health technology assessments of Ikervis® to treat severe keratitis in adult patients with dry eye disease which has not improved despite treatment
Q33837188A novel TRPM8 agonist relieves dry eye discomfort
Q36304636Assessment of Corneal Biomechanical Properties by CorVis ST in Patients with Dry Eye and in Healthy Subjects
Q60046536Association between dry eye disease and asthma: a nationwide population-based study
Q89875479Associations Between Systemic Omega-3 Fatty Acid Levels With Moderate-to-Severe Dry Eye Disease Signs and Symptoms at Baseline in the Dry Eye Assessment and Management Study
Q50079417Calcitriol, the Active Metabolite of Vitamin D3, Inhibits Dry Eye Related Corneal Inflammation In Vivo and In Vitro.
Q38733230Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting
Q89689464Comparative lipidomic analysis of inflammatory mediators in the aqueous humor and tear fluid of humans and rabbits
Q36656777Comparison of the Anti-Inflammatory Effects of Artificial Tears in a Rat Model of Corneal Scraping
Q95729513Conjunctival HLA-DR Expression and Its Association With Symptoms and Signs in the DREAM Study
Q46718255Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease
Q57171838Dry Eye Assessment and Management (DREAM©) Study: Study design and baseline characteristics
Q92824372Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits
Q37485819Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization
Q36137428Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial
Q55112422Efficacy of intra-meibomian gland injection of the anti-VEGF agent bevacizumab for the treatment of meibomian gland dysfunction with lid-margin vascularity.
Q26764956Impact of the Topical Ophthalmic Corticosteroid Loteprednol Etabonate on Intraocular Pressure
Q36393194Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops
Q35825881Lipopolysaccharide challenge significantly influences lipid metabolism and proteome of white adipose tissue in growing pigs
Q38663883MAPK signaling pathways in eye wounds: Multifunction and cooperation
Q47442388Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation.
Q36559274Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations
Q36931629Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
Q52608828Patient and physician perspectives on the use of cyclosporine ophthalmic emulsion 0.05% for the management of chronic dry eye.
Q52558847Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease.
Q57593860Randomised masked trial of the clinical safety and tolerability of MGO Manuka Honey eye cream for the management of blepharitis
Q35928340Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases.
Q47203561Serum components and clinical efficacies of autologous serum eye drops in dry eye patients with active and inactive Sjogren syndrome
Q37084310Static and Dynamic Measurement of Ocular Surface Temperature in Dry Eyes.
Q90481097TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye
Q92543230Tear osmolarity after cataract surgery
Q33838529The Effect of Dry Eye Disease on Scar Formation in Rabbit Glaucoma Filtration Surgery
Q33756582The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research
Q90351231The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options
Q90627752The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface
Q48344821The Use of Topical Corticosteroids for Treatment of Dry Eye Syndrome.
Q50110517Therapeutic inhibitors for the treatment of dry eye syndrome.
Q42078385Therapeutic potential of Polyalthia cerasoides stem bark extracts against oxidative stress and nociception
Q55009490Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study.
Q38787674Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease.
Q88350776n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease
Q36388893α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways

Search more.