The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options

scientific article published on 12 March 2020

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1089/JOP.2019.0060
P932PMC publication ID7175622
P698PubMed publication ID32175799

P2093author name stringVictor L Perez
Daniel R Saban
Meng C Lin
Piergiorgio Neri
Laura M Periman
P2860cites workInflammatory Response in Dry EyeQ93343289
Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye DiseaseQ26774853
NK cells promote Th-17 mediated corneal barrier disruption in dry eyeQ28730069
Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndromeQ33592784
Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease.Q33755012
Mechanisms of action of cyclosporine.Q33908049
Characterization of effector T cells in dry eye diseaseQ34065949
The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogsQ34165372
CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye diseaseQ34211406
The pathology of dry eye.Q34391929
Coordinated regulation of NK receptor expression in the maturing human immune system.Q34476273
Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the Randomized Phase III OPUS-2 StudyQ34493904
The core mechanism of dry eye disease is inflammationQ34510429
Dry eye as a mucosal autoimmune diseaseQ34647761
Patient reported differences in dry eye disease between men and women: impact, management, and patient satisfactionQ35010238
The association between dry eye disease and depression and anxiety in a large population-based studyQ35085765
The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammationQ35145988
A novel pro-lymphangiogenic function for Th17/IL-17.Q35525349
T-cell integrins: more than just sticking pointsQ35576652
The role of the lacrimal functional unit in the pathophysiology of dry eye.Q35755146
Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye diseaseQ35907009
Difluprednate 0.05% versus prednisolone acetate 1% for endogenous anterior uveitis: a phase III, multicenter, randomized studyQ36089582
The effects of oral and topical corticosteroid in rabbit corneasQ36123362
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endotheliumQ36228128
JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cellsQ36380244
PERSIST: Physician's Evaluation of Restasis(®) Satisfaction in Second Trial of topical cyclosporine ophthalmic emulsion 0.05% for dry eye: a retrospective reviewQ36444344
Autoimmunity at the ocular surface: pathogenesis and regulationQ36625074
Tear cytokine profiles in dysfunctional tear syndrome.Q36637791
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
Getting leukocytes to the site of inflammationQ36772662
CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenesQ36804718
Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled StudyQ36877000
The role of the integrin LFA-1 in T-lymphocyte migrationQ36877329
Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease.Q46073610
Lifitegrast for the Treatment of Dry Eye Disease: Results of a Phase III, Randomized, Double-Masked, Placebo-Controlled Trial (OPUS-3).Q46401944
TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cellsQ46561923
The Role of Health Anxiety and Depressive Symptoms in Dry Eye DiseaseQ47611773
Dry eye syndrome: developments and lifitegrast in perspectiveQ47639135
Alterations in corneal stromal dendritic cell phenotype and distribution in inflammationQ47698171
The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for ResearchQ47884949
Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis.Q50994458
Corneal lymphangiogenesis facilitates ocular surface inflammation and cell trafficking in dry eye disease.Q51732139
Thymosin β4 significantly reduces the signs of dryness in a murine controlled adverse environment model of experimental dry eye.Q53459932
Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humansQ59292898
Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-αQ59415968
Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γQ61851323
Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.Q64889532
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)Q68202545
Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen associated with the type three complement receptorQ71439783
Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytesQ73180482
Prevalence of and risk factors for dry eye syndromeQ74298539
Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitisQ74582263
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporineQ77729873
Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective studyQ83540737
Lifitegrast (Xiidra) for Dry Eye DiseaseQ87809124
Suppression of Th1-Mediated Keratoconjunctivitis Sicca by LifitegrastQ89349313
Safety and tolerability of lifitegrast ophthalmic solution 5.0%: Pooled analysis of five randomized controlled trials in dry eye diseaseQ90972349
Dry eye disease: an immune-mediated ocular surface disorderQ36916372
Chronic dry eye disease is principally mediated by effector memory Th17 cellsQ37067291
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
Prevalence, burden, and pharmacoeconomics of dry eye disease.Q37152821
Role of Th1 and Th17 cells in organ-specific autoimmunity.Q37172965
Induction, function and regulation of IL-17-producing T cellsQ37311131
T helper cytokines in dry eye diseaseQ37374838
Dry eye in the beaver dam offspring study: prevalence, risk factors, and health-related quality of lifeQ37715859
Non-hormonal systemic medications and dry eye.Q37949023
Neutrophil arrest by LFA-1 activationQ38018949
Platelet function and thymosin β4.Q38040257
The role and treatment of inflammation in dry eye diseaseQ38270449
Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 geneQ38310590
Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trialQ38414042
Ocular Surface as Barrier of Innate ImmunityQ38544776
Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue InjuriesQ38560551
TFOS DEWS II iatrogenic report.Q38652981
TFOS DEWS II pathophysiology reportQ38652987
TFOS DEWS II Epidemiology ReportQ38652994
TFOS DEWS II Sex, Gender, and Hormones Report.Q38652997
TFOS DEWS II Definition and Classification Report.Q38665717
Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease.Q38810021
LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye DiseaseQ39025675
Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) modelQ39188067
TFOS DEWS II pain and sensation report.Q39453338
TFOS DEWS II Management and Therapy ReportQ39453364
Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanismQ39984665
Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)Q40356553
Systemic Comorbidities of Dry Eye Syndrome: The Korean National Health and Nutrition Examination Survey V, 2010 to 2012.Q40406881
Depression, Stress, Quality of Life, and Dry Eye Disease in Korean Women: A Population-Based StudyQ40910039
Dry Eye Related to Commonly Used New AntidepressantsQ41669051
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study GroupQ41730611
Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 studyQ42708147
Occludin gene expression as an early in vitro sign for mild eye irritation assessmentQ43281284
Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitisQ44491491
ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr miceQ44809776
Comorbidities of dry eye disease: a nationwide population‐based studyQ44866954
Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surfaceQ45158772
Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis siccaQ45190856
Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye.Q45950875
P433issue3
P921main subjecteye diseaseQ3041498
P304page(s)137-146
P577publication date2020-03-12
P1433published inJournal of Ocular Pharmacology and TherapeuticsQ15755845
P1476titleThe Immunological Basis of Dry Eye Disease and Current Topical Treatment Options
P478volume36

Search more.