Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study

scientific article published on 6 April 2016

Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/ICO.0000000000000803
P932PMC publication ID4859202
P698PubMed publication ID27055211

P2093author name stringCharles P Semba
Eric D Donnenfeld
Parag A Majmudar
Aparna Raychaudhuri
Kelly K Nichols
Paul M Karpecki
Monica Roy
P2860cites workA phase 2 randomized, double-masked, placebo-controlled study of a novel integrin antagonist (SAR 1118) for the treatment of dry eyeQ83435570
Molecular mechanisms of T cell co-stimulation and co-inhibitionQ26864888
The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogsQ34165372
Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the Randomized Phase III OPUS-2 StudyQ34493904
The role of the integrin LFA-1 in T-lymphocyte migrationQ36877329
Role of the tear film in the optical quality of the human eye.Q36919382
Etiology, prevalence, and treatment of dry eye diseaseQ37288773
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.Q39730888
Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)Q40356553
Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigrationQ40543299
Mechanisms of inflammation and leukocyte activationQ41333486
Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 studyQ42708147
ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr miceQ44809776
Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye.Q45950875
LFA-1: more than just T cell VelcroQ79227639
Noninvasive, objective, multimodal tear dynamics evaluation of 5 over-the-counter tear drops in a randomized controlled trialQ82791873
P433issue6
P921main subjectmulticenter clinical trialQ6934595
placeboQ269829
eye diseaseQ3041498
lifitegrastQ23044263
P1104number of pages8
P304page(s)741-748
P577publication date2016-04-06
P1433published inCorneaQ15760110
P1476titleSafety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study
P478volume35

Reverse relations

cites work (P2860)
Q64226436A phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease
Q92442286Advances in dry eye disease treatment
Q48095233Current Anti-Integrin Therapy for Ocular Disease
Q57378488Current and emerging therapy of dry eye disease. Part A: pharmacological modalities
Q26746232Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye disease
Q39404635Dry Eye Management: Targeting the Ocular Surface Microenvironment.
Q47639135Dry eye syndrome: developments and lifitegrast in perspective
Q36252489Dysfunctional tear syndrome: dry eye disease and associated tear film disorders - new strategies for diagnosis and treatment
Q39025675LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease
Q39069560Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye Disease
Q59794055Lifitegrast add-on treatment for dupilumab-induced ocular surface disease (DIOSD): A novel case report
Q45037685Lifitegrast clinical efficacy for treatment of signs and symptoms of dry eye disease across three randomized controlled trials
Q38608475Lifitegrast for the treatment of dry eye disease in adults
Q33739879Lifitegrast ophthalmic solution in the treatment of signs and symptoms of dry eye disease: design, development, and place in therapy
Q37591609Lifitegrast: A novel drug for treatment of dry eye disease
Q93137705Lifitegrast: a novel drug for patients with dry eye disease
Q64106425Longitudinal changes in dry eye symptoms and signs following lifitegrast therapy and relationship to tear osmolarity
Q89536542Managing Dry Eye Disease and Facilitating Realistic Patient Expectations: A Review and Appraisal of Current Therapies
Q91935784Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease
Q47268214Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs
Q49261503Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a Phase III randomized controlled trial.
Q58694745Safety and efficacy of lifitegrast 5% ophthalmic solution in contact lens discomfort
Q92236526Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
Q90351231The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options
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