Lifitegrast ophthalmic solution in the treatment of signs and symptoms of dry eye disease: design, development, and place in therapy

scientific article

Lifitegrast ophthalmic solution in the treatment of signs and symptoms of dry eye disease: design, development, and place in therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2147/OPTH.S117188
P932PMC publication ID5449132
P698PubMed publication ID28579745

P2093author name stringMorgan R Godin
Preeya K Gupta
P2860cites workA phase 2 randomized, double-masked, placebo-controlled study of a novel integrin antagonist (SAR 1118) for the treatment of dry eyeQ83435570
Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye diseaseQ26746232
Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye DiseaseQ26774853
Apoptosis of ocular surface cells in experimentally induced dry eye.Q33185569
Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the Randomized Phase III OPUS-2 StudyQ34493904
Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR)Q34735196
Tear cytokine profiles in dysfunctional tear syndrome.Q36637791
Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled StudyQ36877000
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.Q39730888
Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small moleculeQ42162451
Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 studyQ42708147
ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr miceQ44809776
Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cellsQ45158775
Lifitegrast for the Treatment of Dry Eye Disease: Results of a Phase III, Randomized, Double-Masked, Placebo-Controlled Trial (OPUS-3).Q46401944
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
P304page(s)951-957
P577publication date2017-05-22
P1433published inClinical OphthalmologyQ5133782
P1476titleLifitegrast ophthalmic solution in the treatment of signs and symptoms of dry eye disease: design, development, and place in therapy
P478volume11

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cites work (P2860)
Q48498689Assessment and management of dry eye disease.
Q47639135Dry eye syndrome: developments and lifitegrast in perspective
Q61443182Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes
Q58694745Safety and efficacy of lifitegrast 5% ophthalmic solution in contact lens discomfort

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