Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 study

scientific article published on 26 November 2013

Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.OPHTHA.2013.09.015
P698PubMed publication ID24289915

P2093author name stringCharles P Semba
Eugene B McLaurin
Gail L Torkildsen
Francis A D'Ambrosio
John D Sheppard
John D Lonsdale
Kathryn S Kennedy
OPUS-1 Study Group
Richard A Eiferman
P433issue2
P921main subjecteye diseaseQ3041498
lifitegrastQ23044263
P304page(s)475-483
P577publication date2013-11-26
P1433published inOphthalmologyQ7098109
P1476titleLifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 study
P478volume121

Reverse relations

cites work (P2860)
Q43200676A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood.
Q100558870A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation
Q89906657Comparison of the iLUX and the LipiFlow for the Treatment of Meibomian Gland Dysfunction and Symptoms: A Randomized Clinical Trial
Q48095233Current Anti-Integrin Therapy for Ocular Disease
Q57378488Current and emerging therapy of dry eye disease. Part A: pharmacological modalities
Q26746232Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye disease
Q39404635Dry Eye Management: Targeting the Ocular Surface Microenvironment.
Q47639135Dry eye syndrome: developments and lifitegrast in perspective
Q36252489Dysfunctional tear syndrome: dry eye disease and associated tear film disorders - new strategies for diagnosis and treatment
Q91885064Effect of OTX-101, a Novel Nanomicellar Formulation of Cyclosporine A, on Corneal Staining in Patients With Keratoconjunctivitis Sicca: A Pooled Analysis of Phase 2b/3 and Phase 3 Studies
Q51836466Effects of Aging in Dry Eye.
Q35732401Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease
Q38198760Emerging drugs for allergic conjunctivitis
Q33585580Enhanced Tearing by Electrical Stimulation of the Anterior Ethmoid Nerve
Q49834557Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design.
Q36050556Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model.
Q39025675LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease
Q39069560Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye Disease
Q59794055Lifitegrast add-on treatment for dupilumab-induced ocular surface disease (DIOSD): A novel case report
Q45037685Lifitegrast clinical efficacy for treatment of signs and symptoms of dry eye disease across three randomized controlled trials
Q38608475Lifitegrast for the treatment of dry eye disease in adults
Q33739879Lifitegrast ophthalmic solution in the treatment of signs and symptoms of dry eye disease: design, development, and place in therapy
Q26774853Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease
Q37591609Lifitegrast: A novel drug for treatment of dry eye disease
Q93137705Lifitegrast: a novel drug for patients with dry eye disease
Q64106425Longitudinal changes in dry eye symptoms and signs following lifitegrast therapy and relationship to tear osmolarity
Q47442388Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation.
Q26775356Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics
Q33752165Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases
Q47268214Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs
Q49261503Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a Phase III randomized controlled trial.
Q38234039Phase II drugs under investigation for allergic conjunctivitis
Q41615871Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders
Q36877000Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study
Q27342865SkQ1 Ophthalmic Solution for Dry Eye Treatment: Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Model
Q36812082Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease
Q89349313Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast
Q38569837The Future of Dry Eye Treatment: A Glance into the Therapeutic Pipeline
Q90351231The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options
Q41405231The Prospective Health Assessment of Cataract Patients' Ocular Surface (PHACO) study: the effect of dry eye.
Q50110517Therapeutic inhibitors for the treatment of dry eye syndrome.
Q47424328Update in Current Diagnostics and Therapeutics of Dry Eye Disease.
Q47100458Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review
Q50039889[Novel current and future therapy options for treatment of dry eye disease].

Search more.