Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease

scientific article published on 3 February 2016

Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.201500180
P932PMC publication ID4836376
P698PubMed publication ID26842854

P2093author name stringA S Verkman
Scott D Casey
Marc H Levin
Christian M Felix
Alyssa M Flores
Puay W Phuan
P2860cites workPrevalence of dry eye syndrome among US womenQ28196875
Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctivaQ28506507
Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compoundsQ30659857
Green fluorescent protein-based halide indicators with improved chloride and iodide affinitiesQ30993765
Ocular signs and symptoms and vitamin A status in patients with cystic fibrosis treated with daily vitamin A supplementsQ33643019
Prevalence of dry eye disease among US men: estimates from the Physicians' Health StudiesQ33720070
Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.Q34072644
Changes of chloride channels in the lacrimal glands of a rabbit model of Sjögren syndromeQ34096334
The economic burden of dry eye disease in the United States: a decision tree analysisQ34147677
CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal glandQ34266487
Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosisQ34748891
A CFTR potentiator in patients with cystic fibrosis and the G551D mutationQ35591553
Diquafosol tetrasodium: a novel dry eye therapyQ35609725
Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentrationQ36050904
Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiencyQ36120878
A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patientsQ36296284
Regional differences in rat conjunctival ion transport activitiesQ36312382
Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye.Q37139290
Dry eye disease treatment: a systematic review of published trials and a critical appraisal of therapeutic strategies.Q38120327
Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonistsQ40774846
Activation of a CFTR-mediated chloride current in a rabbit corneal epithelial cell lineQ40783049
Comparison of conjunctival and corneal surface areas in rabbit and humanQ41278539
CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differencesQ42476061
Cyclic AMP-dependent stimulation of basolateral K(+)conductance in the rabbit conjunctival epitheliumQ42484831
Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic modelQ42676900
Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 studyQ42708147
Characterization of cyclic AMP-regulated chloride conductance in the pigmented rabbit conjunctival epithelial cellsQ44063629
High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screeningQ44088965
Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye.Q45122469
Production of a severe cystic fibrosis mutation in mice by gene targetingQ45868497
A link between tear instability and hyperosmolarity in dry eye.Q46072952
Active chloride transport in the pigmented rabbit conjunctivaQ46105048
Extraorbital lacrimal gland excision: a reproducible model of severe aqueous tear-deficient dry eye disease.Q50459535
Morphologic effect of hyperosmolarity on rabbit corneal epithelium.Q52501417
Effect of Topical 5-Aminoimidazole-4-carboxamide-1-β-d-Ribofuranoside in a Mouse Model of Experimental Dry Eye.Q53486933
Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface.Q54643325
Ocular findings in cystic fibrosis patients receiving vitamin A supplementationQ58816595
Ophthalmologist Perceptions Regarding Treatment of Moderate-to-Severe Dry Eye: Results of a Physician SurveyQ61759590
Conjunctival goblet cell density in normal subjects and in dry eye syndromesQ66919524
Tear sodium, potassium, chloride, and calcium at various flow rates: children with cystic fibrosis and unaffected siblings with and without corneal stainingQ70001012
Cl- secretagogues increase basolateral K+ conductance of frog corneal epitheliumQ70361708
Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?Q77425439
Effect of topical ophthalmic epinastine and olopatadine on tear volume in miceQ79350933
The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Q80347907
The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)Q80347909
IL-8 and IFN-gamma in tear fluid of patients with cystic fibrosisQ82598340
Tear osmolarity in the diagnosis and management of dry eye diseaseQ83395082
Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eyeQ86904838
Presence of CFTR in the conjunctival epitheliumQ94075927
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
P304page(s)1789-1797
P577publication date2016-02-03
P1433published inFASEB JournalQ520194
P1476titleSmall-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease
P478volume30

Reverse relations

cites work (P2860)
Q51313072Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
Q55185820Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.
Q38715239High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.
Q91620982Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
Q33752165Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases
Q47228449Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice
Q41615871Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders
Q48593751Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice.

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