A phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease

A phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/OPTH.S189039
P932PMC publication ID6387610
P698PubMed publication ID30858682

P2093author name stringGail Torkildsen
Mike Taylor
Ajay Duggal
John D Sheppard
Matthew C T Fyfe
George Ousler
Steve Webber
Adele Rowley
Claire Walshe
P2860cites workPutting vital stains in context.Q50489431
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.Q50888488
Relation between signs and symptoms of dry eye in the elderly. A population-based perspective.Q50933029
Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders.Q54117205
Reliability and validity of the Ocular Surface Disease IndexQ73801624
Economic and Humanistic Burden of Dry Eye Disease in Europe, North America, and Asia: A Systematic Literature ReviewQ26770830
Safety and efficacy of cyclosporine in the treatment of chronic dry eye.Q33825538
Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cellsQ34472557
Cyclosporine ophthalmic emulsions for the treatment of dry eye: a review of the clinical evidenceQ35570541
Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell LossQ36345503
Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled StudyQ36877000
An evaluation of the efficacy of fluorescein, rose bengal, lissamine green, and a new dye mixture for ocular surface stainingQ37052597
An update on dry eye disease molecular treatment: advances in drug pipelinesQ38207723
Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and OlderQ38680274
Report of the Inaugural Meeting of the TFOS i(2) = initiating innovation Series: Targeting the Unmet Need for Dry Eye TreatmentQ38699053
Hot Topics in Dry Eye Disease.Q39032670
Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye DiseaseQ39069560
Dry eye disease in an adult population in South-West NigeriaQ39616989
Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye.Q41316622
Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative ColitisQ41826640
Validation and verification of the OPI 2.0 SystemQ41839224
The Relationship between Habitual Patient-Reported Symptoms and Clinical Signs among Patients with Dry Eye of Varying SeverityQ44631963
Evaluation of a new artificial tear formulation for the management of tear film stability and visual function in patients with dry eye.Q47098857
Use of the Controlled Adverse Environment (CAE) in Clinical Research: A ReviewQ47100458
Key questions in a dry eye history.Q49010135
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
placeboQ269829
DedQ30601669
P304page(s)261-275
P577publication date2019-01-01
P1433published inClinical OphthalmologyQ5133782
P1476titleA phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease
P478volume13

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