scholarly article | Q13442814 |
P50 | author | Cintia Sade de Paiva | Q44473623 |
P2093 | author name string | Stephen C Pflugfelder | |
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Reversible lacrimal gland-protective regulatory T-cell dysfunction underlies male-specific autoimmune dacryoadenitis in the non-obese diabetic mouse model of Sjögren syndrome | Q41592357 | ||
Role of antioxidants in protecting cellular DNA from damage by oxidative stress. | Q41665994 | ||
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group | Q41730611 | ||
Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells | Q42069101 | ||
Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. | Q42173370 | ||
Antimicrobial defensin peptides of the human ocular surface | Q42230623 | ||
Characterisation of the normal conjunctival leukocyte population | Q42444471 | ||
Matrix metalloproteinases in epithelia from human recurrent corneal erosion | Q42471815 | ||
Expression of CCR5 and its ligands CCL3, -4, and -5 in the tear film and ocular surface of patients with dry eye disease | Q42496546 | ||
Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells | Q42504127 | ||
Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo | Q42821897 | ||
Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats | Q43032448 | ||
Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease | Q43723395 | ||
A mouse model of keratoconjunctivitis sicca. | Q43898146 | ||
Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. | Q44327659 | ||
Evaluation of topical cyclosporine for the treatment of dry eye disease | Q44443222 | ||
Lipid peroxidation is increased in tears from the elderly | Q44726191 | ||
Antiinflammatory therapy for dry eye. | Q44763839 | ||
Conjunctival Cytologiec Features of Primary Sjögren's Syndrome | Q44908495 | ||
Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface | Q45158772 | ||
Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells | Q45158775 | ||
Diurnal profiles of tear lysozyme and gamma A globulin | Q45171377 | ||
Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models | Q45269167 | ||
Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye. | Q45950875 | ||
Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. | Q46073610 | ||
Topical Fluorometholone Protects the Ocular Surface of Dry Eye Patients from Desiccating Stress: A Randomized Controlled Clinical Trial. | Q46213404 | ||
Decreased expression of antioxidant enzymes in the conjunctival epithelium of dry eye (Sjögren's syndrome) and its possible contribution to the development of ocular surface oxidative injuries | Q46335254 | ||
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. | Q46412408 | ||
Mucosal environmental sensors in the pathogenesis of dry eye. | Q46859273 | ||
Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye. | Q46893302 | ||
The diurnal variation of matrix metalloproteinase-9 and its associated factors in human tears | Q48259237 | ||
Interleukin-7 and -15 maintain pathogenic memory Th17 cells in autoimmunity. | Q48920345 | ||
Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Mice. | Q50541139 | ||
Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. | Q50721017 | ||
Morphogenesis of rat conjunctival goblet cells. | Q50895891 | ||
Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. | Q50994458 | ||
Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. | Q51549282 | ||
Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren's syndrome-like autoimmune disease. | Q52638716 | ||
Expression of Lipid Peroxidation Markers in the Tear Film and Ocular Surface of Patients with Non-Sjogren Syndrome: Potential Biomarkers for Dry Eye Disease. | Q53177612 | ||
Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. | Q54643325 | ||
Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury. | Q54656929 | ||
Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface. | Q54718619 | ||
Presence of B7-2+Dendritic Cells and Expression of Th1 Cytokines in the Early Development of Sialodacryoadenitis in the IQI/Jic Mouse Model of Primary Sjögren's Syndrome | Q54748526 | ||
Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. | Q54766825 | ||
The practical detection of mmp-9 diagnoses ocular surface disease and may help prevent its complications | Q34294980 | ||
Oxidative stress induced inflammation initiates functional decline of tear production | Q34446876 | ||
Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye. | Q34476263 | ||
Is the corneal degradation in keratoconus caused by matrix-metalloproteinases? | Q34485501 | ||
Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. | Q34585691 | ||
Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer | Q34614045 | ||
Characterization of the normal microbiota of the ocular surface. | Q34782174 | ||
Interferon-γ-secreting NK cells promote induction of dry eye disease | Q35001933 | ||
Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease | Q35040958 | ||
Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye | Q35083557 | ||
Prospective, multicenter, clinical evaluation of point-of-care matrix metalloproteinase-9 test for confirming dry eye disease | Q35197785 | ||
Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. | Q35221255 | ||
Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ | Q35235692 | ||
The intestinal microbiota in inflammatory bowel diseases | Q35256605 | ||
Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. | Q35356313 | ||
Role of the intestinal microbiota and fecal transplantation in inflammatory bowel diseases | Q35412079 | ||
Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells | Q35582470 | ||
Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease | Q35592019 | ||
Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells | Q35646417 | ||
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome | Q35674608 | ||
Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway | Q35675281 | ||
Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease | Q35732401 | ||
Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota. | Q35740373 | ||
IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells | Q35831266 | ||
Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes. | Q35872889 | ||
B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome | Q35957443 | ||
Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells | Q35979980 | ||
Defining the normal core microbiome of conjunctival microbial communities | Q35996436 | ||
Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition | Q36007430 | ||
Toll-like receptor expression and activation in mice with experimental dry eye. | Q36159551 | ||
A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry | Q36283986 | ||
Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss | Q36345503 | ||
JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells | Q36380244 | ||
Hyperosmolarity-Induced Cornification of Human Corneal Epithelial Cells Is Regulated by JNK MAPK | Q56775881 | ||
Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca | Q57693412 | ||
Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes | Q57693415 | ||
Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome | Q58205073 | ||
Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 Production | Q61851319 | ||
Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ | Q61851323 | ||
Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress | Q61851325 | ||
Regulation of MMP-9 production by human corneal epithelial cells. | Q64935616 | ||
Conjunctival goblet cell density in normal subjects and in dry eye syndromes | Q66919524 | ||
Number of inflammatory cells in the normal conjunctiva | Q67374173 | ||
Tumor Necrosis Factor-α Stimulates the Biosynthesis of Matrix Metafloproteinases and Plasminogen Activator in Cultured Human Chorionic Cells | Q67488720 | ||
Identification of lectin binding proteins in human tears | Q67774946 | ||
An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium | Q68257111 | ||
Detection of early xerophthalmia by impression cytology | Q68860338 | ||
The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use | Q69007868 | ||
The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells | Q69735186 | ||
Staging of conjunctival squamous metaplasia by impression cytology | Q69906040 | ||
The concentration of lactoferrin in tears of normals and of diabetics | Q70039623 | ||
Conjunctival goblet cell densities in ocular surface disease | Q70367002 | ||
Possible mechanisms for the loss of goblet cells in mucin-deficient disorders | Q70571012 | ||
Dry eye secondary to mucus deficiency | Q70682647 | ||
Oxidative reactions in the tear fluid of patients suffering from dry eyes | Q70913072 | ||
Proteins in tears from healthy and diseased eyes | Q71510671 | ||
Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitis | Q71784033 | ||
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis | Q72542182 | ||
Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes | Q73180482 | ||
Impression Cytology on Conjunctiva and Cornea in Dry Eye Patients Establishes a Correlation between Squamous Metaplasia and Dry Eye Clinical Severity | Q73273245 | ||
Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis | Q73568681 | ||
Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant | Q73876310 | ||
Active form of gelatinases in tear fluidin patients with corneal ulcer or ocular burn | Q73927817 | ||
Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background | Q74455359 | ||
The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007) | Q80347907 | ||
Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells | Q81435000 | ||
Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease | Q82263589 | ||
Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice | Q83728066 | ||
MaquiBright™ standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clinical pilot trial | Q85289184 | ||
Evaluation of lipid oxidative stress status in Sjögren syndrome patients | Q85430127 | ||
Evaluation of oxidative stress levels in the conjunctival epithelium of patients with or without dry eye, and dry eye patients treated with preservative-free hyaluronic acid 0.15 % and vitamin B12 eye drops | Q85965168 | ||
Th17 cells play a critical role in the development of experimental Sjögren's syndrome | Q87366753 | ||
Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease | Q36474926 | ||
Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway | Q36499692 | ||
Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy | Q36633351 | ||
Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress | Q36642460 | ||
IL-17 disrupts corneal barrier following desiccating stress. | Q36676135 | ||
Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sjögren's syndrome | Q36680491 | ||
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells | Q36767459 | ||
Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome | Q36806556 | ||
Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients. | Q36829070 | ||
Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. | Q36872927 | ||
Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice. | Q36907644 | ||
The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease | Q36926074 | ||
Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye. | Q36985541 | ||
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. | Q36986476 | ||
Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome | Q36990222 | ||
Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. | Q37055739 | ||
Interleukin-7 enhances the Th1 response to promote the development of Sjögren's syndrome-like autoimmune exocrinopathy in mice | Q37060371 | ||
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression | Q37071969 | ||
Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease | Q37129717 | ||
Mucins in the mucosal barrier to infection. | Q37349718 | ||
CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome | Q37407580 | ||
Modulation of conjunctival goblet cell function by inflammatory cytokines | Q37424310 | ||
Matrix metalloproteinases in recurrent corneal melting associated with primary Sjörgen's syndrome. | Q37425263 | ||
Induction of Th17 differentiation by corneal epithelial-derived cytokines | Q37462911 | ||
Topical ophthalmic cyclosporine: pharmacology and clinical uses | Q37473764 | ||
Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye | Q37513125 | ||
Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. | Q37605983 | ||
Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells | Q37737497 | ||
Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. | Q38447815 | ||
Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review | Q38473701 | ||
Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease. | Q38810021 | ||
Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye. | Q38904602 | ||
Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients | Q38907526 | ||
Presence or absence of ocular surface inflammation directs clinical and therapeutic management of dry eye. | Q39030112 | ||
P433 | issue | 11S | |
P921 | main subject | pathophysiology | Q1135939 |
eye disease | Q3041498 | ||
P304 | page(s) | S4-S13 | |
P577 | publication date | 2017-11-01 | |
P1433 | published in | Ophthalmology | Q7098109 |
P1476 | title | The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research | |
P478 | volume | 124 |
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