The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research

scientific article published in November 2017

The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.OPHTHA.2017.07.010
P932PMC publication ID5657523
P698PubMed publication ID29055361

P50authorCintia Sade de PaivaQ44473623
P2093author name stringStephen C Pflugfelder
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Diurnal profiles of tear lysozyme and gamma A globulinQ45171377
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Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium.Q50721017
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The practical detection of mmp-9 diagnoses ocular surface disease and may help prevent its complicationsQ34294980
Oxidative stress induced inflammation initiates functional decline of tear productionQ34446876
Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye.Q34476263
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JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cellsQ36380244
Hyperosmolarity-Induced Cornification of Human Corneal Epithelial Cells Is Regulated by JNK MAPKQ56775881
Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis siccaQ57693412
Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyesQ57693415
Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndromeQ58205073
Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 ProductionQ61851319
Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γQ61851323
Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating StressQ61851325
Regulation of MMP-9 production by human corneal epithelial cells.Q64935616
Conjunctival goblet cell density in normal subjects and in dry eye syndromesQ66919524
Number of inflammatory cells in the normal conjunctivaQ67374173
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Identification of lectin binding proteins in human tearsQ67774946
An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epitheliumQ68257111
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Staging of conjunctival squamous metaplasia by impression cytologyQ69906040
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Conjunctival goblet cell densities in ocular surface diseaseQ70367002
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Dry eye secondary to mucus deficiencyQ70682647
Oxidative reactions in the tear fluid of patients suffering from dry eyesQ70913072
Proteins in tears from healthy and diseased eyesQ71510671
Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitisQ71784033
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Impression Cytology on Conjunctiva and Cornea in Dry Eye Patients Establishes a Correlation between Squamous Metaplasia and Dry Eye Clinical SeverityQ73273245
Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitisQ73568681
Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatantQ73876310
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Evaluation of oxidative stress levels in the conjunctival epithelium of patients with or without dry eye, and dry eye patients treated with preservative-free hyaluronic acid 0.15 % and vitamin B12 eye dropsQ85965168
Th17 cells play a critical role in the development of experimental Sjögren's syndromeQ87366753
Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye diseaseQ36474926
Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative PathwayQ36499692
Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathyQ36633351
Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stressQ36642460
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sjögren's syndromeQ36680491
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cellsQ36767459
Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren SyndromeQ36806556
Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients.Q36829070
Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model.Q36872927
Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice.Q36907644
The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye diseaseQ36926074
Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye.Q36985541
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.Q36986476
Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren SyndromeQ36990222
Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye.Q37055739
Interleukin-7 enhances the Th1 response to promote the development of Sjögren's syndrome-like autoimmune exocrinopathy in miceQ37060371
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host diseaseQ37129717
Mucins in the mucosal barrier to infection.Q37349718
CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndromeQ37407580
Modulation of conjunctival goblet cell function by inflammatory cytokinesQ37424310
Matrix metalloproteinases in recurrent corneal melting associated with primary Sjörgen's syndrome.Q37425263
Induction of Th17 differentiation by corneal epithelial-derived cytokinesQ37462911
Topical ophthalmic cyclosporine: pharmacology and clinical usesQ37473764
Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eyeQ37513125
Ocular surface disease and dacryoadenitis in aging C57BL/6 mice.Q37605983
Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cellsQ37737497
Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial.Q38447815
Probiotics as beneficial agents in the management of diabetes mellitus: a systematic reviewQ38473701
Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease.Q38810021
Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye.Q38904602
Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patientsQ38907526
Presence or absence of ocular surface inflammation directs clinical and therapeutic management of dry eye.Q39030112
P433issue11S
P921main subjectpathophysiologyQ1135939
eye diseaseQ3041498
P304page(s)S4-S13
P577publication date2017-11-01
P1433published inOphthalmologyQ7098109
P1476titleThe Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research
P478volume124

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