Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.

scientific article

Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-14-0234
P932PMC publication ID4233178
P698PubMed publication ID25224277
P5875ResearchGate publication ID265692408

P50authorTimothy F. CloughesyQ47159504
Phioanh NghiemphuQ59440413
Linda LiauQ59749173
Paul MischelQ61594836
Albert LaiQ89181819
Reema ModyQ114422971
Reshmi ChowdhuryQ114444386
Jean K. ReissQ114444390
Robert M. PrinsQ41926442
P2093author name stringFei Liu
Weidong Chen
Tie Li
Arthur P Chou
Horacio Soto
William H Yong
Jerry J Lou
Sichen Li
P2860cites workmiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cellsQ21245271
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulatorsQ24336898
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
Identification of a CpG island methylator phenotype that defines a distinct subgroup of gliomaQ24612429
miRBase: integrating microRNA annotation and deep-sequencing dataQ24615914
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesQ24632807
A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasionQ24633772
An integrated genomic analysis of human glioblastoma multiformeQ24648860
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Releasing the block: setting differentiation free with mutant IDH inhibitors.Q42498717
Epigenetic inactivation of the MIR34B/C in multiple myeloma.Q43422429
Promoter2.0: for the recognition of PolII promoter sequences.Q52212327
Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer.Q54504122
Calcium metabolism, serum thyroid-stimulating hormone, prolactin, and growth hormone in spontaneously hypercholesterolemic ratsQ69957879
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.Q27852141
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
MicroRNA signatures in human cancersQ27860962
CpG islands in vertebrate genomesQ27861045
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAsQ27861053
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiationQ29615366
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotypeQ29617457
Primary brain tumours in adults.Q30765293
CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancerQ33235269
Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profilingQ33848902
Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer.Q34049709
Molecular and Enzymatic Profiles of Mammalian DNA Methyltransferases: Structures and Targets for DrugsQ34143019
DNA methylation silences miR-132 in prostate cancer.Q34252550
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.Q34374136
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.Q34384312
The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancerQ34441849
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.Q35609699
The microcosmos of cancerQ36432986
A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.Q36446183
Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.Q36486875
Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.Q36500377
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.Q36603339
Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcomeQ36627170
A microRNA DNA methylation signature for human cancer metastasisQ36861111
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.Q37381606
MicroRNAs in cancer: small molecules with a huge impactQ37474280
Structure and function of mammalian DNA methyltransferases.Q37829700
The definition of primary and secondary glioblastomaQ38064831
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancerQ39428859
MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancerQ39458980
Epigenetic regulation of microRNA-375 and its role in melanoma development in humans.Q39514244
The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis.Q39709103
Genome-wide analysis in a murine Dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors.Q39928909
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.Q41412954
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectCpG islandQ1138360
hypermethylationQ106875739
P304page(s)5808-5822
P577publication date2014-09-15
P1433published inClinical Cancer ResearchQ332253
P1476titleTumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas
P478volume20

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cites work (P2860)
Q40163473Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics, and microbiota in MRL/lpr mice
Q53433176D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.
Q38861997DNA methylation in adult diffuse gliomas
Q33623176Downregulation of miR-301a-3p sensitizes pancreatic cancer cells to gemcitabine treatment via PTEN
Q47260412EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients
Q28087759Emerging technologies for studying DNA methylation for the molecular diagnosis of cancer
Q90025515Friend or foe-IDH1 mutations in glioma 10 years on
Q38664137Genetic and epigenetic alterations of microRNAs and implications for human cancers and other diseases
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Q38526029Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.
Q33648875MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations
Q35744993MiR-148a, a microRNA upregulated in the WNT subgroup tumors, inhibits invasion and tumorigenic potential of medulloblastoma cells by targeting Neuropilin 1.
Q36771820MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer.
Q26863394New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma
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Q38885469Relationship Between Noncoding RNA Dysregulation and Epigenetic Mechanisms in Cancer
Q36756817The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.
Q26743549The Role of Mir-148a in Cancer
Q61799101miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma
Q93173352miR‑296‑3p promotes the proliferation of glioblastoma cells by targeting ICAT

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