WNK1 is required for mitosis and abscission.

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WNK1 is required for mitosis and abscission. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PNAS..108.1385T
P356DOI10.1073/PNAS.1018567108
P932PMC publication ID3029763
P698PubMed publication ID21220314
P5875ResearchGate publication ID49741912

P50authorMelanie H. CobbQ38327784
P2093author name stringKatherine Luby-Phelps
Abhijit Bugde
Szu-wei Tu
P2860cites workCytokinesis: placing and making the final cut.Q37018205
Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in miceQ37316581
Polo-like kinases: conservation and divergence in their functions and regulationQ37420390
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteinsQ37616620
WNK kinases and blood pressure controlQ37628829
Down-regulation of WNK1 protein kinase in neural progenitor cells suppresses cell proliferation and migrationQ40224268
A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association.Q40328385
Properties of WNK1 and implications for other family membersQ40424747
Metaphase arrest with centromere separation in polo mutants of DrosophilaQ41824169
Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.Q42479166
WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase DomainQ44599907
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertensionQ44970101
Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegansQ47068785
polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.Q47070361
Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.Q47071610
Genome-wide analysis of SPAK/OSR1 binding motifsQ79220162
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane bindingQ24302525
Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamilyQ24304089
Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathwayQ24305919
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomesQ24312101
Structural insights into the recognition of substrates and activators by the OSR1 kinaseQ24338433
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cellsQ24536196
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoformQ24633475
When 2+2=5: the origins and fates of aneuploid and tetraploid cellsQ24658364
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cellsQ24676697
WNK kinases, a novel protein kinase subfamily in multi-cellular organismsQ28188729
Human hypertension caused by mutations in WNK kinasesQ28212182
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain IIQ28581920
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinasesQ28583124
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic interventionQ28591574
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)Q28593751
Automatic and quantitative measurement of protein-protein colocalization in live cells.Q29616276
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.Q31039816
Identification of pathways regulating cell size and cell-cycle progression by RNAiQ33234550
High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instabilityQ33659911
WNK1 activates SGK1 to regulate the epithelial sodium channel.Q33900653
Emerging roles for WNK kinases in cancer.Q34094226
Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscissionQ34457967
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.Q34464530
WNK kinases: molecular regulators of integrated epithelial ion transportQ35858400
Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growthQ35864945
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stressQ36117057
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.Q36711611
Multigene kinase network, kidney transport, and salt in essential hypertensionQ36862737
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1385-1390
P577publication date2011-01-10
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleWNK1 is required for mitosis and abscission
P478volume108

Reverse relations

cites work (P2860)
Q34525997Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Q35790764Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation
Q91773896ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
Q54982623Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway.
Q28581906Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses
Q36368224Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity
Q58775954MicroRNA-144-3p inhibits cell proliferation and induces cell apoptosis in prostate cancer by targeting CEP55
Q34292029Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis
Q35900778Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport
Q37514880Multistep regulation of autophagy by WNK1
Q100533933OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer
Q47296379Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent
Q24304374Similar effects of all WNK3 variants on SLC12 cotransporters
Q64922822The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases.
Q30399038The intrinsic disorder alphabet. III. Dual personality of serine
Q42778113WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation, and migration in part through mitogen-activated protein kinase 7.
Q102053996WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID
Q34576354WNK signaling is involved in neural development via Lhx8/Awh expression
Q55383998WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.
Q47340297WNK1 kinase and the termination factor PCF11 connect nuclear mRNA export with transcription.
Q55284780WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4.
Q30572906WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
Q33603592WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice
Q41781994WNK4 is an essential effector of anterior formation in FGF signaling

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