WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration

scientific article

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1010616060
P356DOI10.1186/1476-4598-13-31
P932PMC publication ID3936893
P698PubMed publication ID24555568
P5875ResearchGate publication ID260369582

P50authorJohn S. KuoQ38328936
P2093author name stringKristopher T Kahle
Dandan Sun
Gulnaz Begum
Wen Zhu
Sung-Sen Yang
Shih-Hua Lin
Paul A Clark
Kelli Pointer
P2860cites workInhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cellsQ36701435
Na+,K+,2Cl- cotransport and intracellular chloride regulation in rat primary sensory neurons: thermodynamic and kinetic aspectsQ36805146
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathwayQ37289702
DNA repair and resistance of gliomas to chemotherapy and radiotherapyQ37553777
Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinasesQ37773549
Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude miceQ39198979
N-methyl-D-aspartate excitotoxicity: relationships among plasma membrane potential, Na(+)/Ca(2+) exchange, mitochondrial Ca(2+) overload, and cytoplasmic concentrations of Ca(2+), H(+), and K(+).Q39516226
AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibitionQ39991860
Properties of WNK1 and implications for other family membersQ40424747
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasisQ40602468
Reduced cell migration, tumor growth and experimental metastasis of rat F-11 cells whose expression of GD3-synthase is suppressedQ40858529
Functional significance of cell volume regulatory mechanisms.Q41697457
Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA releaseQ43952366
A new method for the rapid and long term growth of human neural precursor cellsQ45855413
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressureQ46146557
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanineQ48479768
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of malignant gliomaQ48889258
Merlin and ERM proteins: unappreciated roles in cancer development?Q53372846
Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock.Q53651131
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1Q24548301
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cellsQ24676697
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulationQ27319526
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic interventionQ28591574
Malignant gliomas in adultsQ29615708
LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extensionQ33429488
A key role for membrane transporter NKCC1 in mediating chondrocyte volume increase in the mammalian growth plateQ33536669
Inhibition of the Sodium-Potassium-Chloride Cotransporter Isoform-1 reduces glioma invasionQ33959036
Akt2 phosphorylates ezrin to trigger NHE3 translocation and activationQ34049636
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.Q34464530
WNK1 is required for mitosis and abscission.Q34534234
The WNKs: atypical protein kinases with pleiotropic actions.Q34560188
Emerging role for ERM proteins in cell adhesion and migration.Q34891331
Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.Q35042985
Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migrationQ35216836
With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volumeQ35543284
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylationQ35623025
Ezrin...a metastatic detERMinant?Q35681312
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytesQ35775396
Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition.Q36062158
NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drugQ36552658
Cell volume regulatory ion transport in the regulation of cell migrationQ36634908
Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survivalQ36684457
P4510describes a project that usesImageJQ1659584
P304page(s)31
P577publication date2014-02-20
P1433published inMolecular CancerQ15724585
P1476titleWNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
P478volume13

Reverse relations

cites work (P2860)
Q41501442A pilot study of pre-operative motor dysfunction from gliomas in the region of corticospinal tract: Evaluation with diffusion tensor imaging
Q39382994Administration of Non-Torsadogenic human Ether-à-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients
Q57793352An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis
Q58693846Analysis of potential genes associated with primary cilia in bladder cancer
Q50066649Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma.
Q92236467Cell volume regulation in cancer cell migration driven by osmotic water flow
Q51609445Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors.
Q38708463Computed determination of the in vitro optimal chemocombinations of sphaeropsidin A with chemotherapeutic agents to combat melanomas
Q42371633Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis
Q91773896ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
Q53186244Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients.
Q38765106Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.
Q38307398Going for broke: targeting the human cancer pseudokinome
Q41395890In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines
Q28082580Ion transporters in brain tumors
Q92480527Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a
Q37514880Multistep regulation of autophagy by WNK1
Q90642101NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas
Q100533933OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer
Q92393013Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
Q30397636Pseudokinases: update on their functions and evaluation as new drug targets
Q92659008Roles of glial ion transporters in brain diseases
Q38769340Seizures and gliomas--towards a single therapeutic approach
Q28830269Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase
Q38826790The kinase inhibitor D11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment
Q30586379Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival.
Q39150531WNK Kinases in Development and Disease
Q42778113WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation, and migration in part through mitogen-activated protein kinase 7.
Q48037671WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats.
Q55383998WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.