| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Richard P Lifton | |
| Kristopher T Kahle | |||
| Jesse Rinehart | |||
| P2860 | cites work | WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis | Q24294248 |
| Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily | Q24304089 | ||
| Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter | Q24311551 | ||
| Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2 | Q24313292 | ||
| Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family | Q24320349 | ||
| Structural insights into the recognition of substrates and activators by the OSR1 kinase | Q24338433 | ||
| Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 | Q24548301 | ||
| WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia | Q24621479 | ||
| Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II | Q24648539 | ||
| WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells | Q24676697 | ||
| PASK (Proline-Alanine-rich STE20-related Kinase), a Regulatory Kinase of the Na-K-Cl Cotransporter (NKCC1) | Q28116210 | ||
| The Na-K-Cl cotransporter of secretory epithelia | Q28145935 | ||
| WNK kinases, a novel protein kinase subfamily in multi-cellular organisms | Q28188729 | ||
| Molecular physiology of cation-coupled Cl? cotransport: the SLC12 family | Q28203488 | ||
| The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum | Q28205749 | ||
| Human hypertension caused by mutations in WNK kinases | Q28212182 | ||
| Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform | Q28282071 | ||
| The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation | Q28296169 | ||
| WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion | Q28506376 | ||
| WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II | Q28581920 | ||
| The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases | Q28583124 | ||
| Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia | Q28583667 | ||
| Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1) | Q28593751 | ||
| Excitatory actions of gaba during development: the nature of the nurture | Q29617435 | ||
| The Ste20 group kinases as regulators of MAP kinase cascades | Q29619312 | ||
| A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter. | Q30362605 | ||
| Molecular physiology of the WNK kinases. | Q31134261 | ||
| The manipulation of cation-chloride co-transporters as a novel means to treat persistent pain, epilepsy and other neurological disorders. | Q33398068 | ||
| Sites of regulated phosphorylation that control K-Cl cotransporter activity | Q33609638 | ||
| Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus | Q33624862 | ||
| Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport | Q33736529 | ||
| Sodium-potassium-chloride cotransport | Q33807206 | ||
| Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1. | Q33825021 | ||
| K-Cl cotransport: properties and molecular mechanism | Q34110131 | ||
| In defense of cell volume? | Q40779349 | ||
| The diversity of volume regulatory mechanisms | Q41740526 | ||
| Coordinated regulation of shrinkage-induced Na/H exchange and swelling-induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition | Q41917392 | ||
| Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. | Q42479166 | ||
| Proline- and alanine-rich Ste20-related kinase associates with F-actin and translocates from the cytosol to cytoskeleton upon cellular stresses | Q42803978 | ||
| Direct estimate of 1:1 stoichiometry of K(+)-Cl(-) cotransport in rabbit erythrocytes | Q43705401 | ||
| Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride | Q44174285 | ||
| Electroneutral cation-chloride cotransporters in the central nervous system | Q44781443 | ||
| Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension | Q44970101 | ||
| A volume-sensitive protein kinase regulates the Na-K-2Cl cotransporter in duck red blood cells. | Q46019445 | ||
| The plant WNK gene family and regulation of flowering time in Arabidopsis | Q46398940 | ||
| Activation of the avian erythrocyte Na-K-Cl cotransport protein by cell shrinkage, cAMP, fluoride, and calyculin-A involves phosphorylation at common sites | Q46737953 | ||
| Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. | Q46964954 | ||
| Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans | Q47068785 | ||
| Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain | Q48593744 | ||
| GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity | Q48685135 | ||
| Cation-Chloride Cotransporters in Neuronal Communication | Q48857381 | ||
| WNK4 kinase is a negative regulator of K+-Cl- cotransporters. | Q50641258 | ||
| Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. | Q55044608 | ||
| Genome-wide analysis of SPAK/OSR1 binding motifs | Q79220162 | ||
| CLCN2 variants in idiopathic generalized epilepsy | Q84474172 | ||
| Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. | Q34125574 | ||
| WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. | Q34133418 | ||
| Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain | Q34224419 | ||
| Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter | Q34301998 | ||
| Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. | Q34320496 | ||
| Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). | Q34326671 | ||
| WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. | Q34464530 | ||
| WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia | Q34470465 | ||
| WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway | Q34478816 | ||
| Physiology of cell volume regulation in vertebrates. | Q34602733 | ||
| Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. | Q34694335 | ||
| Regulation of Na-K-2Cl cotransport by phosphorylation and protein-protein interactions | Q34991748 | ||
| Cation-chloride co-transporters in neuronal communication, development and trauma | Q35104788 | ||
| Novel therapies for prevention of erythrocyte dehydration in sickle cell anemia. | Q35159778 | ||
| Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice | Q35785736 | ||
| Cellular volume homeostasis | Q35951180 | ||
| Ion transport pathology in the mechanism of sickle cell dehydration | Q35993299 | ||
| Role of the WNK-activated SPAK kinase in regulating blood pressure | Q36039159 | ||
| Regulation of K-Cl cotransport: from function to genes | Q36042361 | ||
| Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. | Q36079002 | ||
| Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress | Q36117057 | ||
| Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume. | Q36380595 | ||
| GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel | Q36412608 | ||
| Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice | Q36459381 | ||
| WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters | Q36600738 | ||
| Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases | Q36751576 | ||
| Multigene kinase network, kidney transport, and salt in essential hypertension | Q36862737 | ||
| Excitatory actions of GABA in the suprachiasmatic nucleus. | Q36944420 | ||
| SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells | Q37037656 | ||
| The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures | Q37256766 | ||
| Roles of the cation-chloride cotransporters in neurological disease. | Q37260267 | ||
| Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl. | Q39196381 | ||
| Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity | Q40042307 | ||
| Properties of WNK1 and implications for other family members | Q40424747 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 9 | |
| P304 | page(s) | 1150-1158 | |
| P577 | publication date | 2010-07-15 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases | |
| P478 | volume | 1802 |
| Q90421224 | "I don't get no respect": the role of chloride in acute kidney injury |
| Q33846396 | A novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation |
| Q28486016 | A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function |
| Q54557642 | An autocrine neuronal interleukin-6 loop mediates chloride accumulation and NKCC1 phosphorylation in axotomized sensory neurons. |
| Q30435769 | CGRP inhibits neurons of the bed nucleus of the stria terminalis: implications for the regulation of fear and anxiety |
| Q35578616 | Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line |
| Q27683663 | Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation |
| Q91121458 | Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease |
| Q41668962 | Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility |
| Q35882568 | Critical role of the SPAK protein kinase CCT domain in controlling blood pressure |
| Q27004031 | Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2 |
| Q43095476 | Dependence of corneal epithelial cell proliferation on modulation of interactions between ERK1/2 and NKCC1. |
| Q36041911 | Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation |
| Q26825616 | Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema |
| Q92220740 | Divergent selection and drift shape the genomes of two avian sister species spanning a saline-freshwater ecotone |
| Q48572492 | Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1. |
| Q55120336 | Energetic evolution of cellular Transportomes. |
| Q46289235 | Enhanced FGF23 serum concentrations and phosphaturia in gene targeted mice expressing WNK-resistant SPAK. |
| Q26786331 | Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases |
| Q38136071 | GABAA receptor-mediated tonic depolarization in developing neural circuits |
| Q43075608 | GABAA receptor: a unique modulator of excitability, Ca(2+) signaling, and catecholamine release of rat chromaffin cells |
| Q27335346 | GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. |
| Q38984830 | Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy |
| Q92462997 | Genomics of rapid ecological divergence and parallel adaptation in four tidal marsh sparrows |
| Q48425577 | Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation |
| Q28581906 | Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses |
| Q54492768 | Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells. |
| Q36701435 | Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells |
| Q37963359 | Is it safe to use a diuretic to treat seizures early in development ? |
| Q35780018 | Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases |
| Q36598125 | Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target |
| Q36952282 | Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport |
| Q89254963 | Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance |
| Q27321234 | Modeling glial contributions to seizures and epileptogenesis: cation-chloride cotransporters in Drosophila melanogaster |
| Q92480527 | Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a |
| Q26829362 | Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2 |
| Q35900778 | Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport |
| Q48637510 | OSR1-sensitive renal tubular phosphate reabsorption. |
| Q54481013 | OSR1-sensitive small intestinal Na+ transport. |
| Q50442022 | Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres |
| Q39437434 | Pendrin overexpression affects cell volume recovery, intracellular pH and chloride concentration after hypotonicity-induced cell swelling |
| Q55136943 | Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats. |
| Q40989179 | Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter |
| Q39415845 | Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. |
| Q34823865 | Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures |
| Q35471348 | Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures. |
| Q36572034 | Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation |
| Q27319526 | Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation |
| Q90621981 | Regulation of erythrocyte Na+/K+/2Cl- cotransport by an oxygen-switched kinase cascade |
| Q90444955 | Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor-KCC2 Pathway after Spinal Cord Injury |
| Q35760379 | Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD |
| Q35543406 | Role of an apical K,Cl cotransporter in urine formation by renal tubules of the yellow fever mosquito (Aedes aegypti). |
| Q21129489 | Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission |
| Q48592650 | SPAK and OSR1 sensitivity of voltage-gated K+ channel Kv1.5. |
| Q48595475 | SPAK-sensitive regulation of glucose transporter SGLT1. |
| Q50102613 | Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? |
| Q92378159 | Slc26 Family of Anion Transporters in the Gastrointestinal Tract: Expression, Function, Regulation, and Role in Disease |
| Q39356593 | Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway |
| Q30486743 | The Concise Guide to PHARMACOLOGY 2013/14: transporters |
| Q38826790 | The kinase inhibitor D11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment |
| Q26851296 | The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders |
| Q35583015 | Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor |
| Q83842074 | Volume regulation in mammalian skeletal muscle: the role of sodium-potassium-chloride cotransporters during exposure to hypertonic solutions |
| Q37694287 | WNK signalling pathways in blood pressure regulation |
| Q48037671 | WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. |
| Q30572906 | WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration |
| Q41974321 | WNK1/HSN2 isoform and the regulation of KCC2 activity |
| Q39773177 | With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters |
| Q37076873 | Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling |
| Q33994691 | siRNA-mediated inhibition of Na(+)-K(+)-2Cl- cotransporter (NKCC1) and regulatory volume increase in the chondrocyte cell line C-20/A4. |
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