AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition

scientific article

AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1124/MOL.107.044743
P698PubMed publication ID18413665
P5875ResearchGate publication ID5438366

P2093author name stringEnzo Bonmassar
Ester Alvino
Lauretta Levati
Simona Caporali
Stefania D'Atri
Giuseppe Starace
Gianluca Ragone
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
temozolomideQ425088
P304page(s)173-183
P577publication date2008-04-15
P1433published inMolecular PharmacologyQ1943386
P1476titleAKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition
P478volume74

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cites work (P2860)
Q60913185ATR activated by EB virus facilitates chemotherapy resistance to cisplatin or 5-fluorouracil in human nasopharyngeal carcinoma
Q61764523Activation Mechanism of Protein Kinase B by DNA-dependent Protein Kinase Involved in the DNA Repair System
Q39137614Activation of ERK1/2 and Akt is associated with cisplatin resistance in human lung cancer cells
Q40678340Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF.
Q34223641Akt: a double-edged sword in cell proliferation and genome stability
Q53222808An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
Q39228006Aspirin-/TMZ-coloaded microspheres exert synergistic antiglioma efficacy via inhibition of β-catenin transactivation.
Q37457876Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells
Q36796975Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence
Q35025940Characterization of the pituitary tumor transforming gene 1 knockout mouse retina
Q37387342Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells
Q37321206Combination of lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy eradicates malignant glioma through cell apoptosis and cell cycle arrest.
Q39069931Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer
Q28271163DNA damage and the balance between survival and death in cancer biology
Q39895269DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif
Q51776110Downregulation of RUVBL1 inhibits proliferation of lung adenocarcinoma cells by G1/S phase cell cycle arrest via multiple mechanisms.
Q37615208Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade
Q38680891In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells
Q39294625Mammalian PER2 regulates AKT activation and DNA damage response
Q36545028Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo
Q92733028Metformin as Potential Therapy for High-Grade Glioma
Q36552658NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug
Q59355600Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo
Q35648484Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Q37012650Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.
Q38974279Prospects for the Use of ATR Inhibitors to Treat Cancer.
Q34182228Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.
Q34193741Role of AKT signaling in DNA repair and clinical response to cancer therapy
Q36741098Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells.
Q39575976Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.
Q46255359The Cdk inhibitor flavopiridol enhances temozolomide-induced cytotoxicity in human glioma cells
Q49349544The dual PI3K/mTOR inhibitor dactolisib elicits anti-tumor activity in vitro and in vivo
Q30572906WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration

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