Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.

scientific article

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1025551964
P356DOI10.1186/1743-8977-8-1
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/1743-8977-8-1
P932PMC publication ID3030505
P698PubMed publication ID21235812
P5875ResearchGate publication ID49756212

P50authorToshiro HiraiQ56046753
Yasuo TsutsumiQ74564858
Yasuo YoshiokaQ88203254
Kazuya NaganoQ92363591
Hiromi NabeshiQ117253917
Tomoaki YoshikawaQ117253920
Norio ItohQ117253930
Keigo MatsuyamaQ117253931
Yasutaro NakazatoQ117253932
Saeko TochigiQ117253933
Sayuri KondohQ117253934
Takanori AkaseQ117253935
Haruhiko KamadaQ42947634
Yasuhiro AbeQ55128434
Shin-ichi TsunodaQ55188793
P2860cites workOxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubesQ23909527
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of ironQ23923113
Applications of nanoparticles in biology and medicineQ24562054
The aging processQ24616537
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationQ24631966
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silicaQ24649598
Toxic potential of materials at the nanolevelQ28295314
Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytesQ28343984
Quantitative nanostructure-activity relationship modelingQ28385022
Acute toxicity and prothrombotic effects of quantum dots: impact of surface chargeQ28386619
Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathwaysQ28394622
Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injuryQ28512867
Carbon fullerenes (C60s) can induce inflammatory responses in the lung of miceQ28590068
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot studyQ29547366
NOX enzymes and the biology of reactive oxygenQ29547517
Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigmQ29615517
Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotubeQ29615576
Predictive QSAR modeling workflow, model applicability domains, and virtual screeningQ33316534
A central role for the endothelial NADPH oxidase in atherosclerosisQ33899130
Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transportQ34008468
Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytesQ77319140
Acute toxicological effects of copper nanoparticles in vivoQ81484464
Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stressQ84095647
Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticlesQ94698916
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseasesQ34256779
A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes.Q34315445
Cell-specific targeting of nanoparticles by multivalent attachment of small moleculesQ34462201
Mechanisms of genotoxicity of particles and fibersQ34745478
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosisQ35146205
Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particlesQ36362072
Localizing NADPH oxidase-derived ROS.Q36574300
Perturbational profiling of nanomaterial biologic activityQ36677215
Macrophage responses to silica nanoparticles are highly conserved across particle sizesQ37091537
Effects of nanomaterial physicochemical properties on in vivo toxicity.Q37345372
Toward the development of "nano-QSARs": advances and challengesQ37605014
Nanoparticle-induced pulmonary toxicityQ37780881
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal ruptureQ39690953
Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shapeQ39736798
Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cellsQ39750055
Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.Q39754381
Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells.Q39773218
Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouseQ39778619
Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B.Q39825368
Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assaysQ39993544
Silica nanoparticles as hepatotoxicantsQ40001053
In vitro toxicity of silica nanoparticles in human lung cancer cellsQ40207105
Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticlesQ40445279
Calcium-dependent PAF-stimulated generation of reactive oxygen species in a human keratinocyte cell lineQ40948370
Generation of reactive oxygen species in a human keratinocyte cell line: role of calciumQ41065033
Nanomaterial cytotoxicity is composition, size, and cell type dependentQ42429077
Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicityQ42809592
Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 ratsQ42975666
Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules.Q43104183
Toxicological characteristics of nanoparticulate anatase titanium dioxide in miceQ43254632
Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection.Q43789480
Effects of subchronic exposure to multi-walled carbon nanotubes on miceQ45154930
Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells.Q46033103
In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection.Q46155143
Effects of cytochalasin, phalloidin, and pH on the elongation of actin filaments.Q52455490
Toxicological Aspects of Long‐Term Treatment of Keratinocytes with ZnO and TiO2 NanoparticlesQ53308874
ZnO particulate matter requires cell contact for toxicity in human colon cancer cells.Q54258017
P921main subjectkeratinocyteQ1473931
P304page(s)1
P577publication date2011-01-15
P1433published inParticle and Fibre ToxicologyQ15724404
P1476titleAmorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes
P478volume8

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cites work (P2860)
Q46639069Acellular reactivity of polymeric dendrimer nanoparticles as an indicator of oxidative stress in vitro
Q36026619Amorphous nanosilica particles evoke vascular relaxation through PI3K/Akt/eNOS signaling
Q38946952Amorphous silica nanoparticles alter microtubule dynamics and cell migration
Q39395704Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects
Q38295282Applications of the comet assay in particle toxicology: air pollution and engineered nanomaterials exposure
Q29247883Autophagy as a Possible Underlying Mechanism of Nanomaterial Toxicity
Q28389467Biocompatibility assessment of Si-based nano- and micro-particles
Q42145536Carbon Nanomaterials: Efficacy and Safety for Nanomedicine.
Q37700003Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface
Q61815162Cellular Responses of Industrially Relevant Silica Dust on Human Glial Cells In Vitro
Q38748407Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epithelial BEAS-2B cells
Q29248684Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors
Q28074825Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity
Q28087733Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations
Q39836284Cytotoxicity, oxidative stress, and inflammation in human Hep G2 liver epithelial cells following exposure to gold nanorods.
Q37198453Development of novel drug delivery systems using phage display technology for clinical application of protein drugs
Q35134878Effect of silica particle size on macrophage inflammatory responses
Q28391402Evaluation of Airborne Particle Emissions from Commercial Products Containing Carbon Nanotubes
Q46950699Evaluation of cellular effects of silicon dioxide nanoparticles.
Q37204240Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials
Q53296265Evaluation of protective effect of freeze-dried strawberry, grape, and blueberry powder on acrylamide toxicity in mice.
Q56834568Focusing the research efforts
Q39480376Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells
Q28389006Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)
Q46248479Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles
Q36368022Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles
Q28394270Intracellular accumulation dynamics and fate of zinc ions in alveolar epithelial cells exposed to airborne ZnO nanoparticles at the air-liquid interface
Q40414188Leishmania recombinant antigen modulates macrophage effector function facilitating early clearance of intracellular parasites
Q39309843Mechanism of cellular uptake of genotoxic silica nanoparticles
Q112704099Mesoporous Silica-Coated Gold Nanoparticles for Multimodal Imaging and Reactive Oxygen Species Sensing of Stem Cells
Q46544436Modification of the in vitro uptake mechanism and antioxidant levels in HaCaT cells and resultant changes to toxicity and oxidative stress of G4 and G6 poly(amidoamine) dendrimer nanoparticles
Q39375890Multifunctional Polymer-Coated Carbon Nanotubes for Safe Drug Delivery
Q37209624Multinucleation and cell dysfunction induced by amorphous silica nanoparticles in an L-02 human hepatic cell line
Q91810508N-acetylcysteine reverses the decrease of DNA methylation status caused by engineered gold, silicon, and chitosan nanoparticles
Q36526580Oxidative Damage and Energy Metabolism Disorder Contribute to the Hemolytic Effect of Amorphous Silica Nanoparticles
Q38989175PEGylation of ORMOSIL nanoparticles differently modulates the in vitro toxicity toward human lung cells.
Q38257079Perspectives on percutaneous penetration: Silica nanoparticles
Q36032890Potential Release of Manufactured Nano Objects During Sanding of Nano-Coated Wood Surfaces
Q39024010Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells
Q41680397Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size
Q28387080Short-term inhalation of cadmium oxide nanoparticles alters pulmonary dynamics associated with lung injury, inflammation, and repair in a mouse model
Q37748095SiO2 and TiO2 nanoparticles synergistically trigger macrophage inflammatory responses
Q98945385Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-Cells
Q28397602Silica Nanoparticles Induce Oxidative Stress and Autophagy but Not Apoptosis in the MRC-5 Cell Line
Q83772051Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Q34702892Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro.
Q41553420The Effects of Silica Nanoparticles on Apoptosis and Autophagy of Glioblastoma Cell Lines.
Q39426079The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNA damage in HaCaT cells
Q28486314Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint
Q46276221Toxicity of Copper Oxide (CuO) Nanoparticles on Human Blood Lymphocytes
Q39345498Toxicology of silica nanoparticles: an update
Q28392537UVB Dependence of Quantum Dot Reactive Oxygen Species Generation in Common Skin Cell Models
Q39096381Ultraviolet radiation and nanoparticle induced intracellular free radicals generation measured in human keratinocytes by electron paramagnetic resonance spectroscopy.

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