Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia

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Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI112667
P932PMC publication ID423772
P698PubMed publication ID2428841

P2093author name stringE F Plow
T J Kunicki
M H Ginsberg
A Kaufmann
G Marguerie
A Lightsey
P2860cites workLIGAND: A versatile computerized approach for characterization of ligand-binding systemsQ29547346
The different glycoprotein abnormalities in thrombasthenic and Bernard-Soulier plateletsQ33457322
Exposure of platelet fibrinogen receptors by ADP and epinephrineQ33473239
Relationship between fibrinogen binding and the platelet glycoprotein deficiencies in Glanzmann's thrombasthenia type I and type II.Q33478516
Mechanisms of postprandial glucose counterregulation in man. Physiologic roles of glucagon and epinephrine vis-a-vis insulin in the prevention of hypoglycemia late after glucose ingestionQ33821886
Identification and function of the high affinity binding sites for Ca2+ on the surface of plateletsQ34604791
Reduced surface expression and binding of fibronectin by thrombin-stimulated thrombasthenic plateletsQ35204377
Binding of fibronectin to alpha-granule-deficient plateletsQ36207659
Platelet-collagen adhesion: evidence for participation of antigenically distinct entitiesQ36211997
Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb.Q36212080
Immunochemical evidence for protein abnormalities in platelets from patients with Glanzmann's thrombasthenia and Bernard-Soulier syndromeQ37021542
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibodyQ37026661
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibodyQ37609861
The binding of calcium to fibrinogen: Some structural featuresQ39163838
Factors responsible for ADP-induced release reaction of human plateletsQ39340022
Reconstruction of platelet proteins into phospholipid vesicles. Functional proteoliposomesQ40917716
Human platelets possess an inducible and saturable receptor specific for fibrinogenQ41629256
The role of cell surface proteins in platelet stimulation by monosodium urate crystals.Q50716117
Calcium cation regulation of glycoprotein IIb-IIIa complex formation in platelet plasma membranesQ54491133
Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsinQ66955875
Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complexQ67294160
Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresisQ67556563
Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total proteinQ67656123
Calcium regulation of the platelet membrane glycoprotein IIb-IIIa complexQ67918454
Fibrinogen binding to human platelet plasma membranes. Identification of two steps requiring divalent cationsQ70158677
Complex formation of platelet membrane glycoproteins IIb and IIIa: a model of platelet activationQ70189528
Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human plateletsQ70265119
Isolation, purification, and partial characterization of platelet membrane glycoproteins IIb and IIIaQ70539259
The formation of Ca++-dependent complexes of platelet membrane glycoproteins IIb and IIIa in solution as determined by crossed immunoelectrophoresisQ70549345
Interaction of specific platelet membrane proteins with collagen: evidence from chemical cross-linkingQ70581513
Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregationQ71127880
Heterogeneity of membrane surface proteins in Glanzmann's thrombastheniaQ71431024
Correlation between fibrinogen binding to human platelets and platelet aggregabilityQ71496685
Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complexQ72762726
Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complexQ72771425
Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodiesQ72779664
Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact plateletsQ72797414
Interaction of human platelet membrane glycoproteins with collagen and lectinsQ72804393
The platelet-fibrinogen interaction. Evidence for proximity of the A alpha chain of fibrinogen to platelet membrane glycoproteins IIb/IIIQ72807391
Identification of the fibrinogen receptor on human platelets by photoaffinity labelingQ72932817
Fibrinogen-binding properties of the human platelet glycoprotein IIb-=IIIa complex: a study using crossed-radioimmunoelectrophoresisQ72939301
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1103-1111
P577publication date1986-10-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleDivalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia
P478volume78

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cites work (P2860)
Q34221553A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation
Q36220539A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis
Q40668561A review of the role of platelet membrane glycoproteins in the platelet-vessel wall interaction
Q37387501A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding
Q38720521Activation-enhanced alpha(IIb)beta(3)-integrin-cytoskeleton interactions outside of focal contacts require the alpha-subunit
Q30479636Activation-independent platelet adhesion and aggregation under elevated shear stress
Q41710125Are changes in integrin affinity and conformation overemphasized?
Q41517642Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes
Q41326692Calcium-dependent conformation of a mouse macrophage calcium-type lectin. Carbohydrate binding activity is stabilized by an antibody specific for a calcium-dependent epitope
Q71875963Characterization of a new hereditary thrombopathy in a closed colony of Wistar rats
Q33418861Discovery and Correction of Spurious Low Platelet Counts due to EDTA-Dependent Pseudothrombocytopenia.
Q71742597Dissociation of the alphaIIbbeta3-integrin by EGTA stimulates the tyrosine kinase pp72(syk) without inducing platelet activation
Q41650080Divalent cation regulation of the function of the leukocyte integrin LFA-1
Q41050898Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins
Q34560935Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction
Q73487466Expression and function of calcium binding domain chimeras of the integrins alpha(IIb) and alpha(5)
Q36354693Fibronectin receptors of phagocytes. Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes
Q36081222Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit
Q34207017Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association
Q69534846Glanzmann's thrombasthenia
Q34859954Glanzmann's thrombasthenia: an overview
Q36870012Hematologically Important Mutations: Glanzmann Thrombasthenia
Q30513893Heparin modulates the conformation and signaling of platelet integrin αIIbβ3
Q41564510Homotypic leukocyte aggregation triggered by a monoclonal antibody specific for a novel epitope expressed by the integrin β1 subunit: Conversion of nonresponsive cells by transfecting human integrin α4 subunit cDNA
Q40920150Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism
Q33382672Inherited bleeding disorders
Q24317407Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
Q68506495Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex
Q71655421Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding
Q41481792Ligand binding and affinity modulation of integrins
Q46298719Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit
Q35804502Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation
Q28216926Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment
Q34353018Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function
Q71823689Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium
Q36233314Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin
Q33672239Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa
Q53941628Platelets and soluble fibrin promote plasminogen activation causing downregulation of platelet glycoprotein Ib/IX complexes: protection by aprotinin.
Q40785864Probing conformational changes in the I-like domain and the cysteine-rich repeat of human beta 3 integrins following disulfide bond disruption by cysteine mutations: identification of cysteine 598 involved in alphaIIbbeta3 activation
Q41915162Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets
Q67699877Quantitative isolation of RNA from human platelets
Q33407595Sensitivity of assays for the detection of HPA-1a antibodies: results of an international workshop demonstrating the impact of cation chelation from integrin αIIbβ3 on three widely used assays
Q90292261Structure of an extended β3 integrin
Q41553346The biologic and clinical spectrum of Glanzmann's thrombasthenia: implications of integrin alpha IIb beta 3 for its pathogenesis
Q71070336The ligand recognition specificity of beta3 integrins
Q35998499The regulation of integrin function by divalent cations
Q35039053Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi
Q42066333Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit
Q40348390alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan
Q89777927αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible

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