Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

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Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function. is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2017.00045
P932PMC publication ID5293812
P698PubMed publication ID28223936

P50authorMartin BielQ51156453
Christian GrimmQ87958680
P2093author name stringChristian Wahl-Schott
Cheng-Chang Chen
P2860cites workDifferential roles of syntaxin 7 and syntaxin 8 in endosomal traffickingQ22010801
Single-channel currents recorded from membrane of denervated frog muscle fibresQ22337286
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic stateQ24315101
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signalingQ24316454
NAADP mobilizes calcium from acidic organelles through two-pore channelsQ24318546
TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal FunctionQ24338758
Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusionQ24550710
A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and functionQ24595623
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin eggQ24600390
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cellsQ24600457
Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6Q24633280
Two-pore channels at the intersection of endolysosomal membrane trafficQ28085768
High susceptibility to fatty liver disease in two-pore channel 2-deficient miceQ28246421
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsQ28260464
TPC: the NAADP discovery channel?Q28262391
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomesQ28276964
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphateQ28299232
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinasesQ28307378
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal storesQ28585336
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosomeQ29543488
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.Q30810815
P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.Q33792971
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal traffickingQ33816664
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV.Q34234776
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.Q34315702
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatmentQ34464824
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signalingQ34480730
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.Q34483914
Two-Pore Channels: Lessons from Mutant Mouse ModelsQ34531617
The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationQ34583526
Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosisQ34701623
Two newly identified genetic determinants of pigmentation in EuropeansQ34779376
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signalingQ35055509
Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interactionQ36290839
Lysosomes: fusion and functionQ36885390
TPC2 controls pigmentation by regulating melanosome pH and sizeQ36931154
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosisQ37224430
The delivery of endocytosed cargo to lysosomesQ37597369
NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoaQ37635358
A tale of two CLCs: biophysical insights toward understanding ClC-5 and ClC-7 function in endosomes and lysosomesQ38513388
NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy.Q38717578
Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving forceQ38754504
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.Q38788245
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.Q39271543
Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.Q39627828
TRPM2 functions as a lysosomal Ca2+-release channel in beta cellsQ39849413
Corrigendum: A melanosomal two-pore sodium channel regulates pigmentationQ40971753
Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channelQ41251219
Departure gate of acidic Ca²⁺ confirmedQ41791017
Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.Q41820235
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium releaseQ41822869
Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.Q41880567
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the HeartQ43099248
BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release.Q50976144
Planar patch clamp approach to characterize ionic currents from intact lysosomes.Q51552498
Patch clamp study of the voltage-dependent anion channel in the thylakoid membrane.Q54000428
Endosome-lysosome fusion.Q55053647
Ion channels in the chloroplast envelope membraneQ70782801
Effects of D2O on permeation and gating in the Ca(2+)-activated potassium channel from CharaQ72239329
Ions switch off darkness: role of TPC2 in melanosomesQ87891696
P304page(s)45
P577publication date2017-02-07
P1433published inFrontiers in PharmacologyQ2681208
P1476titleTwo-Pore Channels: Catalyzers of Endolysosomal Transport and Function
P478volume8