MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation

scientific article

MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OR.2010.1079
10.3892/OR.2010.1090
P932PMC publication ID3041593
P698PubMed publication ID21152872

P50authorJae J SongQ60313016
P2093author name stringYong J Lee
So Y Kim
Bo K Sun
Hoan N Nguyen
Joo-Hang Kim
Seeun Oh
Sujin Choi
Hye J Choi
P2860cites workDirect activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.Q24292137
Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)Q24295263
Identification and characterization of a new member of the TNF family that induces apoptosisQ24318423
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine familyQ24320301
Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamilyQ24654366
Signal transduction by the JNK group of MAP kinasesQ28142592
A link between metastasis and resistance to apoptosis of variant small cell lung carcinomaQ28239805
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]Q28280257
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.Q33940485
MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosisQ33996873
c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatmentQ34250032
Mammalian Sterile20-like kinase 1 and the regulation of apoptosisQ34322331
Survival-promoting functions of 14-3-3 proteinsQ34797105
TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.Q35009467
The CD95(APO-1/Fas) DISC and beyondQ35091401
14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteinsQ35624026
Mitogen-activated protein kinases in apoptosis regulationQ35743118
Targeting death receptors in cancer with Apo2L/TRAIL.Q35834889
Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways.Q36477045
TRAIL signalling: decisions between life and death.Q36778214
Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cellsQ39842626
Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorptionQ40144580
Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL.Q40207500
Differential activation of the JNK signal pathway by UV irradiation and glucose deprivationQ40222274
Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion.Q40279060
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligandQ40361361
Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanismsQ40560857
Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell deathQ40594593
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.Q40975748
TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathwaysQ40992331
Anti-cell death activity promotes pulmonary metastasis of melanoma cellsQ41104241
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activationQ42057774
The involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein (MAP) kinase in TRAIL/Apo2L-induced apoptosisQ45711503
TRAIL-induced death of human adult oligodendrocytes is mediated by JNK pathway.Q46736950
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3betaQ80860090
P433issue2
P921main subjectphosphorylationQ242736
P304page(s)537-544
P577publication date2010-12-07
P1433published inOncology ReportsQ7092098
P1476titleMEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation
P478volume25

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cites work (P2860)
Q4885914414-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway.
Q34487441CCR7 regulates cell migration and invasion through JAK2/STAT3 in metastatic squamous cell carcinoma of the head and neck
Q37003894Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes
Q47291846DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells.
Q37407344HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4).
Q59072618Protein Kinase C (PKC) Isozymes and Cancer
Q39305649Restoring TRAIL Induced Apoptosis Using Naturopathy. Hercules Joins Hand with Nature to Triumph Over Lernaean Hydra.
Q34333852Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells
Q35946035STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death.
Q28384960TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways
Q33993124The role of chemoattractant receptors in shaping the tumor microenvironment.
Q34123342p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes

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