14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins

scientific article published on December 1992

14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/0968-0004(92)90339-B
P698PubMed publication ID1471260
P5875ResearchGate publication ID21684979

P2093author name stringIsobe T
Aitken A
Soll J
Roseboom PH
Rosenfeld G
Collinge DB
van Heusden BP
P433issue12
P1104number of pages4
P304page(s)498-501
P577publication date1992-12-01
P1433published inTrends in Biochemical SciencesQ1565711
P1476title14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins
P478volume17

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cites work (P2860)
Q2823558814-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner
Q6180909314-3-3 Protein of Modulates Host Cell Innate Immunity Through the Activation of MAPK and NF-κB Pathways
Q2793142914-3-3 Proteins Are Essential for RAS/MAPK Cascade Signaling during Pseudohyphal Development in S. cerevisiae
Q5528075214-3-3 Proteins in Plant Hormone Signaling: Doing Several Things at Once.
Q2856816414-3-3 beta in the healthy and diseased male reproductive system
Q4440630114-3-3 dimers probe the assembly status of multimeric membrane proteins
Q4495483614-3-3 gene characterization and description of a second 14-3-3 isoform in both Echinococcus granulosus and E. multilocularis.
Q2433810314-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5
Q2431973814-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner
Q3444533814-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction
Q2453190514-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation
Q3617537314-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification?
Q4446310014-3-3 proteins are constituents of the insoluble glycoprotein framework of the chlamydomonas cell wall
Q2432404114-3-3 proteins associate with cdc25 phosphatases
Q4810337014-3-3 proteins bind to histone and affect both histone phosphorylation and dephosphorylation
Q7806827614-3-3 proteins control proteolysis of nitrate reductase in spinach leaves
Q5503354814-3-3 proteins form a guidance complex with chloroplast precursor proteins in plants.
Q4402612914-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform
Q4797470014-3-3 proteins in neuronal development and function
Q2826078814-3-3 proteins interact with specific MEK kinases
Q3206443214-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor
Q7213946714-3-3 proteins on the MAP
Q3483495014-3-3 proteins participate in light signaling through association with PHYTOCHROME INTERACTING FACTORs
Q4052139314-3-3 proteins. Hot numbers in signal transduction
Q3584199414-3-3 proteins: a number of functions for a numbered protein
Q3372995814-3-3 proteins: eukaryotic regulatory proteins with many functions
Q3370654514-3-3 proteins: potential roles in vesicular transport and Ras signaling in Saccharomyces cerevisiae
Q3569969114-3-3 proteins: regulation of signal-induced events
Q3714963714-3-3s are potential biomarkers for HIV-related neurodegeneration
Q2730321114-3-3ε Is required for germ cell migration in Drosophila
Q3907021114-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation
Q3643518714-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle
Q47070572A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Q72423707A fusicoccin binding protein belongs to the family of 14-3-3 brain protein homologs
Q36839102A gene variation of 14-3-3 zeta isoform in rat hippocampus
Q36937993A genetic modifier screen identifies multiple genes that interact with Drosophila Rap/Fzr and suggests novel cellular roles
Q39084744A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins
Q41484383A qualitative and quantitative protein database approach identifies individual and groups of functionally related proteins that are differentially regulated in simian virus 40 (SV40) transformed human keratinocytes: an overview of the functional cha
Q34616833A robust protocol to map binding sites of the 14-3-3 interactome: Cdc25C requires phosphorylation of both S216 and S263 to bind 14-3-3
Q48092372A single Arabidopsis GF14 isoform possesses biochemical characteristics of diverse 14-3-3 homologues
Q40617015Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex
Q24324360Activation of Raf-1 by 14-3-3 proteins
Q74456167An Arabidopsis 14-3-3 protein can act as a transcriptional activator in yeast
Q48040600An Arabidopsis gene encoding a putative 14-3-3-interacting protein, caffeic acid/5-hydroxyferulic acid O-methyltransferase
Q33722268An ordered EST catalogue and gene expression profiles of cassava (Manihot esculenta) at key growth stages
Q33649855Annexin V and phospholipid metabolism
Q54649952Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein.
Q34275495Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis.
Q45230944Association of 14-3-3gamma and phosphorylated bad attenuates injury in ischemic astrocytes
Q22253912Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression
Q40789573Bcr and Raf form a complex in vivo via 14-3-3 proteins
Q73084597Binding to 14-3-3 proteins is not sufficient to inhibit nitrate reductase in spinach leaves
Q35005803Cerebrospinal fluid brain-derived proteins in the diagnosis of Alzheimer's disease and Creutzfeldt-Jakob disease
Q58894532Changes in the proteome of pea (Pisum sativum L.) seeds germinating under optimal and osmotic stress conditions and subjected to post-stress recovery
Q40738596Characterization of proteins that regulate calcium-dependent exocytosis in adrenal chromaffin cells
Q28294839Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in intact cells
Q42159924Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle
Q44376516Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis
Q49076335Clinical and therapeutic aspects of prion disease
Q42635947Cloning and characterization of the 14-3-3 protein gene from the halotolerant alga Dunaliella salina
Q48046375Cloning and expression of an Arabidopsis gene encoding a putative peroxisomal ascorbate peroxidase
Q39627965Cloning of Schistosoma japonicum 14-3-3 epsilon (Sj14-3-3 epsilon), a new member of the 14-3-3 family of proteins from schistosomes
Q22010378Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23
Q64948066Cold tolerance response mechanisms revealed through comparative analysis of gene and protein expression in multiple rice genotypes.
Q24294271Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
Q32132961Diagnosis of Creutzfeldt-Jakob disease and related human spongiform encephalopathies
Q39980089Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes
Q43809348Differential expression of proteins in brain regions of Alzheimer's disease patients
Q58805754Dimerization of Arabidopsis 14-3-3 proteins: structural requirements within the N-terminal domain and effect of calcium
Q24648178Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function
Q52536968Dominant-negative alleles of 14-3-3 proteins cause defects in actin organization and vesicle targeting in the yeast Saccharomyces cerevisiae.
Q40876917Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes
Q90111469Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism
Q64963980EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica.
Q48443522Enhanced expression of 14-3-3 family members in injured motoneurons
Q36541588Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice
Q34169043Evolution and isoform specificity of plant 14-3-3 proteins
Q48086605Evolutionary implications of the family of 14-3-3 brain protein homologs in Arabidopsis thaliana
Q39467997Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression
Q71420766Four Arabidopsis thaliana 14-3-3 protein isoforms can complement the lethal yeast bmh1 bmh2 double disruption
Q46248444Free energy calculations on the stability of the 14-3-3ζ protein
Q28283426Function of 14-3-3 proteins
Q60082336Function of 14-3-3 proteins
Q24291878Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis
Q35040486Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants
Q74806144Fungal Infection of Plants
Q74776242Fusicoccin Binding to Its Plasma Membrane Receptor and the Activation of the Plasma Membrane H+-ATPase (III. Is There a Direct Interaction between the Fusicoccin Receptor and the Plasma Membrane H+-ATPase?)
Q74270872Fusicoccin Counteracts the n-Ethylmaleimide and Silver-Induced Stimulation of Oxygen Uptake in Egeria densa Leaves
Q74264606Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H(+)-ATPase. IV. Fusicoccin induces the association between the plasma membrane H(+)-ATPase and the fusicoccin receptor
Q74358961Fusicoccin effect on the in vitro interaction between plant 14-3-3 proteins and plasma membrane H+-ATPase
Q57171097Genome-wide identification and characterization of the 14-3-3 family in Vitis vinifera L. during berry development and cold- and heat-stress response
Q47907060High expression level of a gene coding for a chloroplastic amino acid selective channel protein is correlated to cold acclimation in cereals
Q40053731IDENTIFICATION AND EXPRESSION ANALYSIS OF TWO 14-3-3 PROTEINS IN THE MOSQUITO Aedes aegypti, AN IMPORTANT ARBOVIRUSES VECTOR.
Q49281038Identification and Expression Analysis of Wheat TaGF14 Genes
Q42981706Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation
Q57132561Identification of 14-3-3-like protein in sugarcane (Saccharum officinarum)
Q28278900Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha
Q42620975Identification of a key domain in annexin and 14-3-3 proteins that stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells
Q48985218Identification of a potential physiological substrate for oncogenic Ras-activated protein kinases in activated Xenopus egg extracts: correlation with oncogenic Ras-induced cell cycle arrest
Q24534993Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta
Q28475176Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum
Q38440220Immunocytochemical detection of 14-3-3 in primary nervous system tumors
Q53366646Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Q43753321Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction
Q57673140Inherited Cardiomyopathies and the Role of Mutations in Non-coding Regions of the Genome
Q43612897Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association
Q28534347Interkingdom complementation reveals structural conservation and functional divergence of 14-3-3 proteins
Q74038115Intrinsic nucleoside diphosphate kinase-like activity as a novel function of 14-3-3 proteins
Q48333547Ischemic rat brains contain immunoreactivity of 14-3-3 proteins
Q53231720Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Q28579247Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy
Q28293607Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins
Q42018648Isolation and expression analysis of a homolog of the 14-3-3 epsilon gene in the diamondback moth, Plutella xylostella
Q43991302Isolation and structure of the mouse 14-3-3 eta chain gene and the distribution of 14-3-3 eta mRNA in the mouse brain
Q36871097Isolation of a Dictyostelium discoideum 14-3-3 homologue
Q48074779Isolation, sequencing, and analysis of a 14-3-3 brain protein homolog from pea (Pisum sativum L.).
Q24304413MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1
Q34585256MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation
Q40793685MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria.
Q44266506Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo
Q42752618Mechanism of inhibition of protein kinase C by 14-3-3 isoforms. 14-3-3 isoforms do not have phospholipase A2 activity
Q37617682MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx
Q22254010Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon
Q35780325Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice
Q33255637Molecular and immunological characterization of encoding gene and 14-3-3 protein 1 in Fasciola gigantica.
Q33283235Molecular characterization of cotton 14-3-3L gene preferentially expressed during fiber elongation
Q31408844Molecular cloning and characterization of a novel Schistosoma japonicum "irradiated vaccine-specific" antigen, Sj14-3-3.
Q28505782Molecular cloning and tissue-specific expression of the mouse homologue of the rat brain 14-3-3 θ protein: Characterization of its cellular and developmental pattern of expression in the male germ line
Q48059858Molecular evolution of the 14-3-3 protein family
Q48061631Molecular organization and tissue-specific expression of an Arabidopsis 14-3-3 gene
Q38320200Mutational analysis of Raf-1 cysteine rich domain: requirement for a cluster of basic aminoacids for interaction with phosphatidylserine.
Q52553630Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.
Q35857584Network Cluster Analysis of Protein-Protein Interaction Network-Identified Biomarker for Type 2 Diabetes
Q38533541New Insights into the Protein Turnover Regulation in Ethylene Biosynthesis
Q35871733Nonstructural proteins NS2 of minute virus of mice associate in vivo with 14-3-3 protein family members
Q34038310Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease
Q50581346Nucleotide sequence and expression of the 14-3-3 from the halotolerant alga Dunaliella salina.
Q72999350Nucleotide sequence, genomic organization and cell-cycle-dependent expression of a Chlamydomonas 14-3-3 gene
Q48875098Olfactory learning deficits in mutants for leonardo, a Drosophila gene encoding a 14-3-3 protein
Q94464428Over-Expression of a 14-3-3 Protein From Foxtail Millet Improves Plant Tolerance to Salinity Stress in Arabidopsis thaliana
Q48045908Over-expression of plant 14-3-3 proteins in tobacco: enhancement of the plasmalemma K+ conductance of mesophyll cells
Q39611856Overexpression of the Arabidopsis 14-3-3 protein GF14 lambda in cotton leads to a "stay-green" phenotype and improves stress tolerance under moderate drought conditions
Q37910359PKC-delta and PKC-epsilon: foes of the same family or strangers?
Q38353528Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin.
Q48142079Phosphorylation and calcium binding properties of an Arabidopsis GF14 brain protein homolog
Q34389442Phosphorylation of 14-3-3ζ at serine 58 and neurodegeneration following kainic acid-induced excitotoxicity
Q58168584Phosphorylation of human chromosome maintenance 1 mediates association with 14-3-3 proteins
Q24312109Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166
Q45786217Polyoma virus middle T antigen: meddler or mimic?
Q70920291Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase C
Q22254220Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32
Q28139665Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins
Q40939214Protein-protein interactions. Putting the pieces together
Q38442179Proteomic identification of rainbow trout seminal plasma proteins
Q28609134Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins
Q51112497Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3ζ-binding sites reveals key differences between MAP2c and its homolog Tau.
Q39767003Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferation
Q40580165Radiation checkpoints in model systems
Q34549833Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration
Q24316278Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins
Q40504332Regulation of protein kinase C and role in cancer biology.
Q54441560Relative expression of the 14-3-3 gene in different morphotypes of cysts of Echinococcus granulosus isolated from the Indian buffalo.
Q42492186Rice 14-3-3 protein (GF14e) negatively affects cell death and disease resistance
Q36241760Role of 14-3-3 proteins in eukaryotic signaling and development
Q36939450Role(s) of the serine/threonine protein phosphatase 1 on mammalian sperm motility
Q28214568Selective association of protein kinase C with 14-3-3 zeta in neuronally differentiated PC12 Cells. Stimulatory and inhibitory effect of 14-3-3 zeta in vivo
Q48049903Sequence and expression analysis of a Xenopus laevis cDNA which encodes a homologue of mammalian 14-3-3 zeta protein.
Q49829669Single-Molecule Fluorescence Methods to Study Plant Hormone Signal Transduction Pathways
Q28346729Specific binding of vf14-3-3a isoform to the plasma membrane H+-ATPase in response to blue light and fusicoccin in guard cells of broad bean
Q47852989Stage-specific expression of 14-3-3 in asexual blood-stage Plasmodium
Q32065830Stage-specific expression of the 14-3-3 gene in Echinococcus multilocularis.
Q71816119Stimulation of catecholamine secretion from adrenal chromaffin cells by 14‐3‐3 proteins is due to reorganisation of the cortical actin network
Q48667801Structure and sites of phosphorylation of 14-3-3 protein: role in coordinating signal transduction pathways.
Q38016600Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience
Q43817985Subcellular distribution of 14-3-3 proteins in the unicellular green alga Chlamydomonas reinhardtii
Q44533686Subcellular localization of 14-3-3 proteins in Toxoplasma gondii tachyzoites and evidence for a lipid raft-associated form.
Q50486190Subcellular localization of full-length human myeloid leukemia factor 1 (MLF1) is independent of 14-3-3 proteins.
Q37970918Targeting 14-3-3zeta in cancer therapy
Q35635340The 14-3-3 cancer connection
Q48636298The 14-3-3 protein binds its target proteins with a common site located towards the C-terminus
Q50509135The 14-3-3 protein is secreted by the adult worm of Echinococcus granulosus.
Q48074840The 14-3-3 proteins encoded by the BMH1 and BMH2 genes are essential in the yeast Saccharomyces cerevisiae and can be replaced by a plant homologue
Q27935625The GCKIII kinase Sps1 and the 14-3-3 isoforms, Bmh1 and Bmh2, cooperate to ensure proper sporulation in Saccharomyces cerevisiae
Q89340338The family of 14-3-3 proteins and specifically 14-3-3σ are up-regulated during the development of renal pathologies
Q72716872The fusicoccin receptor of plants is a member of the 14-3-3 superfamily of eukaryotic regulatory proteins
Q40525099The genetics of cell cycle checkpoints
Q71171758The inhibitor protein of phosphorylated nitrate reductase from spinach (Spinacia oleracea) leaves is a 14-3-3 protein
Q45775966The overexpression of 14-3-3ζ and Hsp27 promotes non–small cell lung cancer progression
Q34700244The regulation of erythropoiesis by selenium in mice.
Q94544437The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma
Q73817045Two homologous low-temperature-inducible genes from Arabidopsis encode highly hydrophobic proteins
Q36675690Two related low-temperature-inducible genes of Arabidopsis encode proteins showing high homology to 14-3-3 proteins, a family of putative kinase regulators.
Q32085762Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells
Q28143097Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family
Q74428453p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions

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