14-3-3 proteins: a number of functions for a numbered protein

scientific article published on 13 July 2004

14-3-3 proteins: a number of functions for a numbered protein is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1126/STKE.2422004RE10
P698PubMed publication ID15266103

P2093author name stringDave Bridges
Greg B G Moorhead
P2860cites workProtein kinase C inhibitor proteins. Purification from sheep brain and sequence similarity to lipocortins and 14-3-3 proteinQ48259445
Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiationQ48899475
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilonQ22254010
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localizationQ22254367
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targettingQ24290893
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulationQ24291204
Functional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 proteinQ24314987
14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent mannerQ24319738
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activationQ24319934
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserineQ24322674
Activation of Raf-1 by 14-3-3 proteinsQ24324360
Interaction of the protein kinase Raf-1 with 14-3-3 proteinsQ24329122
Identification of a signal-responsive nuclear export sequence in class II histone deacetylasesQ24550848
Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylasesQ24648367
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteinsQ24673877
14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphataseQ24681544
Involvement of 14-3-3 proteins in nuclear localization of telomeraseQ24685623
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand bindingQ27619633
Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivoQ44266506
14-3-3 dimers probe the assembly status of multimeric membrane proteinsQ44406301
14-3-3zeta C-terminal stretch changes its conformation upon ligand binding and phosphorylation at Thr232.Q44653252
Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.Q44702812
The 14-3-3 proteins encoded by the BMH1 and BMH2 genes are essential in the yeast Saccharomyces cerevisiae and can be replaced by a plant homologueQ48074840
Structural view of a fungal toxin acting on a 14-3-3 regulatory complexQ27640587
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathwaysQ27729753
Crystal structure of the zeta isoform of the 14-3-3 proteinQ27729754
14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic grooveQ27758986
Raster3D: photorealistic molecular graphicsQ27860557
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiaeQ27860755
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Global mapping of the yeast genetic interaction networkQ27934987
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivoQ28140320
Assembly of Cell Regulatory Systems Through Protein Interaction DomainsQ28155799
The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit. Evidence for a dynamic role in subunit stabilizationQ28188947
The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migrationQ28201887
Role of the 14-3-3 C-terminal loop in ligand interactionQ28205100
BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein TargetingQ28212263
Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signalsQ28215227
Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1Q28216136
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteinsQ28273233
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activityQ28276506
14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter moleculesQ28284411
Data mining the Arabidopsis genome reveals fifteen 14-3-3 genes. Expression is demonstrated for two out of five novel genesQ28351256
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathwaysQ28588530
14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylationQ29041812
The structural basis for 14-3-3:phosphopeptide binding specificityQ29547190
ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic informationQ29547192
Multiple sequence alignment with Clustal XQ29547758
14-3-3 proteins: structure, function, and regulationQ29619100
Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein PhosphatasesQ30464289
Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage displayQ30776583
The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609.Q30811815
The Giardia lamblia genomeQ30850507
14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cellsQ30880095
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand bindingQ31149686
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociationQ32061766
14-3-3 proteins in the nervous systemQ33188355
14-3-3 proteins: potential roles in vesicular transport and Ras signaling in Saccharomyces cerevisiaeQ33706545
Protein phosphorylation and signal transductionQ33716076
Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear importQ33890764
Mechanism of the F(1)F(0)-type ATP synthase, a biological rotary motorQ33957859
How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesisQ34120299
The origins of protein phosphorylationQ34126615
14-3-3 proteins: regulation of subcellular localization by molecular interferenceQ34127838
Phosphoserine/threonine-binding domainsQ34180612
Checking out the G(2)/M transition.Q34282259
14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.Q34284257
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylationQ34439988
14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interactionQ34445338
Structural basis for control by phosphorylationQ34465974
Phosphotyrosine-binding domains in signal transductionQ34627225
Specificity of 14-3-3 isoform dimer interactions and phosphorylationQ34797095
Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRL1 and AFX.Q34797172
Function and specificity of 14-3-3 proteins in the regulation of carbohydrate and nitrogen metabolismQ35036804
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variantsQ35040486
14-3-3 protein is a regulator of the mitochondrial and chloroplast ATP synthaseQ35062365
ER Export: Call 14-3-3Q35127910
14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteinsQ35624026
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulationQ35684376
Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.Q35787179
14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinaseQ36844606
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target bindingQ37155705
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylationQ37367473
Expression and structural analysis of 14-3-3 proteins.Q38299549
Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin.Q38353528
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteinsQ40568858
Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535.Q40581778
Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3 sigma and 14-3-3 zetaQ40583043
Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.Q40609126
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complexQ40674756
Cellular regulation by protein phosphorylation: a historical overviewQ41588533
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and traffickingQ42125847
The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interfaceQ42799340
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.Q42800762
Adenosine 5'-monophosphate inhibits the association of 14-3-3 proteins with the plant plasma membrane H(+)-ATPaseQ43651951
Binding of regulatory 14-3-3 proteins to the C terminus of the plant plasma membrane H+ -ATPpase involves part of its autoinhibitory regionQ43715896
Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contractionQ43857529
P433issue242
P304page(s)re10
P577publication date2004-07-13
P1433published inScience's STKE : signal transduction knowledge environmentQ27714885
P1476title14-3-3 proteins: a number of functions for a numbered protein.
P478volume2004

Reverse relations

cites work (P2860)
Q3358412814-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis
Q2826233014-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA
Q3343937314-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4.
Q2811538714-3-3eta is a novel regulator of parkin ubiquitin ligase
Q42468308A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis
Q34157631A Proteome-wide Domain-centric Perspective on Protein Phosphorylation
Q40030085Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.
Q40066989Arachidonic acid binds 14-3-3zeta, releases 14-3-3zeta from phosphorylated BAD and induces aggregation of 14-3-3zeta
Q33980033Characterization of the Brain 26S Proteasome and its Interacting Proteins
Q40106235Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4.
Q64939258Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake.
Q45374796Distinct regions at the N-terminus of the Cucumber necrosis virus coat protein target chloroplasts and mitochondria
Q35813584Downregulation of urea transporter UT-A1 activity by 14-3-3 protein
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Q39964105Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.
Q35768552Structural basis for protein-protein interactions in the 14-3-3 protein family
Q39708356Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function
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Q38442245Transcriptome analysis of sugar beet root maggot (Tetanops myopaeformis) genes modulated by the Beta vulgaris host

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