Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.

scientific article

Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M804308200
P932PMC publication ID3259841
P698PubMed publication ID18606808
P5875ResearchGate publication ID5245814

P50authorKevin H. GardnerQ37837105
Richard M WynnQ61159379
P2093author name stringHiroyuki Mizuguchi
Joyce J Repa
Kosaku Uyeda
Wan-Ru Lee
Masashi Fukasawa
Haruhiko Sakiyama
P2860cites workStructural basis for protein-protein interactions in the 14-3-3 protein familyQ35768552
14-3-3 proteins: a number of functions for a numbered proteinQ35841994
Lipid metabolism in the liver.Q36712398
Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.Q38313248
Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genesQ38345565
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanismQ40336619
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and traffickingQ42125847
A simplified method for the preparation of transcriptionally active liver nuclear extractsQ45275178
Elucidating the folding problem of alpha-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters.Q52231700
A mechanism of regulation of hepatic Fru 2,6-P2 concentration upon refeeding: involvement of xylulose 5-P and cyclic-AMPQ71077615
Glucose-stimulated synthesis of fructose 2,6-bisphosphate in rat liver. Dephosphorylation of fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase and activation by a sugar phosphateQ72724524
Interaction of 14-3-3 with a nonphosphorylated protein ligand, exoenzyme S of Pseudomonas aeruginosaQ77357874
Mechanisms of Receptor-Mediated Nuclear Import and Nuclear ExportQ22065647
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localizationQ22254367
Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?Q22254702
WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor networkQ24290883
The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3Q24294330
Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding proteinQ24555088
A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleusQ24563147
Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-ZipQ24647758
Involvement of 14-3-3 proteins in nuclear localization of telomeraseQ24685623
Structure of importin-beta bound to the IBB domain of importin-alphaQ27618407
Crystal structure of the zeta isoform of the 14-3-3 proteinQ27729754
The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2)Q27766431
Nucleocytoplasmic transport: the soluble phaseQ28131723
Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinaseQ28572688
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverQ28583240
JPred: a consensus secondary structure prediction serverQ29614378
Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage displayQ30776583
The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609.Q30811815
Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genesQ34387089
Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing moduleQ34518615
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liverQ34532657
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)24899-24908
P577publication date2008-07-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleRegulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation
P478volume283

Reverse relations

cites work (P2860)
Q34233730A novel N-terminal domain may dictate the glucose response of Mondo proteins
Q28741436AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells
Q34215266Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region
Q91639207Carbohydrate Sensing Through the Transcription Factor ChREBP
Q34787111ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells
Q36489303Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop
Q24292984Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site
Q55050296Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein.
Q41682989Differential expression and accumulation of 14-3-3 paralogs in 3T3-L1 preadipocytes and differentiated cells
Q26996783Energy metabolism in the liver
Q37613511Fatty acid-regulated transcription factors in the liver
Q54538841Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.
Q39764892Glucose induces expression of rat pyruvate carboxylase through a carbohydrate response element in the distal gene promoter
Q28506748Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells
Q38160330Hepatic glucose sensing and integrative pathways in the liver
Q33676739High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy
Q88770188Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non‑alcoholic fatty liver disease
Q35150109Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP).
Q51014106Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice
Q38546818Mechanisms Regulating Protein Localization.
Q36898193Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR
Q37201325Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies.
Q47610334Modulators of 14-3-3 Protein-Protein Interactions
Q28828461MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
Q50294407Nuclear transport of pChREBP (Thr 666) protein
Q64076256Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity
Q39445103Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease
Q50294404PhosphoChREBP (Thr 666) is exported to cytosol
Q42144044Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation
Q36106288Predicting diabetes mellitus genes via protein-protein interaction and protein subcellular localization information
Q39510465Proteomic analysis of the interleukin-4 (IL-4) response in hepatitis B virus-positive human hepatocelluar carcinoma cell line HepG2.2.15.
Q45351517Proteomic and bioinformatic analysis of membrane proteome in type 2 diabetic mouse liver
Q58795278Recent insights into the role of ChREBP in intestinal fructose absorption and metabolism
Q36451937Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein.
Q35663711The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity
Q39216040The regulation and role of carbohydrate response element binding protein in metabolic homeostasis and disease.
Q34631988Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses
Q33672543Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.
Q26778594Transcriptional regulation of hepatic lipogenesis
Q50694806Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP).

Search more.