Hepatic glucose sensing and integrative pathways in the liver

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Hepatic glucose sensing and integrative pathways in the liver is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00018-013-1505-Z
P698PubMed publication ID24196749

P50authorKristina SchoonjansQ28468900
P2093author name stringMaaike H Oosterveer
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The hyperlipidemia in glycogen storage diseaseQ70893481
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Two CACGTG Motifs with Proper Spacing Dictate the Carbohydrate Regulation of Hepatic Gene TranscriptionQ72036860
Stereospecific transport of glucose in the perfused rat liverQ72128168
Measurements of electron spin resonance with the pyruvate dehydrogenase complex from Escherichia coli. Studies on the allosteric binding site of acetyl-coenzyme AQ72393054
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Ribose 1,5-bisphosphate is a putative regulator of fructose 6-phosphate/fructose 1,6-bisphosphate cycle in liverQ73669384
Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stressQ80489672
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomasQ82615010
Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factorsQ22010918
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Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologueQ24293122
Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase geneQ24297189
Phosphofructokinase 1 glycosylation regulates cell growth and metabolismQ24297510
SIRT1 deacetylates and positively regulates the nuclear receptor LXRQ24297669
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolismQ24298588
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolismQ24298601
Regulation of cellular metabolism by protein lysine acetylationQ24300091
Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeatsQ24310656
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteinsQ24312912
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistanceQ24315875
Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type IbQ24320082
Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activityQ24336875
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferationQ24336894
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancerQ24337240
Hexosamines, insulin resistance, and the complications of diabetes: current statusQ24538581
MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like networkQ24551066
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityQ24595845
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Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in DrosophilaQ27323381
Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometryQ27334695
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1Q27652923
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Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificityQ28141169
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CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availabilityQ28245419
The Sir2 family of protein deacetylasesQ28266179
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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinaseQ28508079
The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAXQ28511983
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolismQ28513195
The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXRQ28513664
O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitinationQ28513755
Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeatsQ28581400
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverQ28583240
Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammationQ28592904
Isolation of the gene for murine glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1AQ28594080
Critical nodes in signalling pathways: insights into insulin actionQ29614735
ATP-citrate lyase links cellular metabolism to histone acetylationQ29615367
New nomenclature for chromatin-modifying enzymesQ29616425
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesisQ29617241
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucoseQ30437005
Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosisQ47927518
Pyruvate carboxylaseQ48464317
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liverQ50336015
Coenzyme A and its thioester pools in fasted and fed rat tissues.Q51389505
Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway.Q51551557
Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis.Q51665999
The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.Q54426511
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.Q54538841
Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humansQ60462242
Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liverQ61203329
Glucose 6-Phosphate Produced by Glucokinase, but Not Hexokinase I, Promotes the Activation of Hepatic Glycogen SynthaseQ63224144
Differential Metabolic Effects of Adenovirus-mediated Glucokinase and Hexokinase I Overexpression in Rat Primary HepatocytesQ63224151
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alphaQ64377758
The disposal of an oral glucose load in healthy subjects. A quantitative studyQ69896265
Nuclear receptors and the control of metabolismQ35041181
The metabolically benign and malignant fatty liverQ35123495
A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasomeQ35140884
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.Q35149156
Evolution of the Max and Mlx networks in animalsQ35224604
Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferationQ35345655
The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switchingQ35485292
Hepatocytes: critical for glucose homeostasisQ35733130
O-GlcNAc signalling: implications for cancer cell biologyQ35793071
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liverQ35796929
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic diseaseQ35804446
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver diseaseQ35809618
Cellular metabolism and disease: what do metabolic outliers teach us?Q35915928
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humansQ36005304
LRH-1-dependent glucose sensing determines intermediary metabolism in liverQ36129076
Mechanistic insights into the regulation of metabolic enzymes by acetylationQ36135254
Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.Q36243408
Glucose as a regulator of eukaryotic gene transcriptionQ36306015
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.Q36315965
Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytesQ36523378
Decreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemiaQ36635387
Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expressionQ36657518
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Q36693487
Hepatic glucose sensing is required to preserve β cell glucose competenceQ36733443
Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.Q36792618
Regulation of Akt signaling by O-GlcNAc in euglycemia.Q36956006
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic healthQ37088326
Influence of metabolism on epigenetics and diseaseQ37177814
Cracking the O-GlcNAc code in metabolism.Q37197417
Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liverQ37200875
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling AtlasQ37214995
Glycogen storage disease type Ia: linkage of glucose, glycogen, lactic acid, triglyceride, and uric acid metabolismQ37266937
Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis.Q37333458
The role of the lipogenic pathway in the development of hepatic steatosis.Q37386081
FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrolQ37431323
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease statesQ37445714
Physiologic action of glucagon on liver glucose metabolismQ37726825
Functional lysine modification by an intrinsically reactive primary glycolytic metaboliteQ37734916
Brain, liver, intestine: a triumvirate to coordinate insulin sensitivity of endogenous glucose productionQ37826508
An extended Myc network contributes to glucose homeostasis in cancer and diabetes.Q37881596
Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysisQ37928607
The many faces of insulin-like peptide signalling in the brainQ37994953
Allosteric post-translational modification codesQ38033852
O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.Q38059293
Novel insights into ChREBP regulation and function.Q38099905
O-GlcNAc cycling: a link between metabolism and chronic diseaseQ38103951
Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitinationQ38119185
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.Q38311106
O-GlcNAc regulates FoxO activation in response to glucoseQ30439420
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famineQ33625053
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAcQ33802435
c-Myc is required for the CHREBP-dependent activation of glucose-responsive genesQ33874328
The SLC2 (GLUT) family of membrane transportersQ33926133
Diabetes mellitus, fasting glucose, and risk of cause-specific deathQ33945937
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.Q33953637
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic functionQ33966115
Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.Q33980061
Evolution and regulatory role of the hexokinasesQ34066227
Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective mannerQ34107422
The key role of anaplerosis and cataplerosis for citric acid cycle function.Q34135762
Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.Q34148239
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.Q34195003
The impact of acetylation and deacetylation on the p53 pathwayQ34199692
Glucokinase and cytosolic phosphoenolpyruvate carboxykinase (GTP) in the human liver. Regulation of gene expression in cultured hepatocytesQ34214063
A novel N-terminal domain may dictate the glucose response of Mondo proteinsQ34233730
A two-way street: reciprocal regulation of metabolism and signalling.Q34259242
Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle EntryQ34298938
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clockQ34326979
Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone codeQ34359019
Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genesQ34387089
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolismQ34411887
Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene LociQ34448627
Protein posttranslational modifications: the chemistry of proteome diversificationsQ34465021
Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch dietQ34471563
Genomic structure of the human glucose 6-phosphate translocase gene and novel mutations in the gene of a Japanese patient with glycogen storage disease type Ib.Q34483795
Transcriptional regulation of metabolismQ34511703
Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing moduleQ34518615
Glycogen storage disease type I: pathophysiology of liver adenomasQ34528044
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liverQ34532657
Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysisQ34537111
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.Q35027765
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistanceQ38314419
Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genesQ38345565
Constitutive hepatic glucokinase activity in db/db and ob/ob miceQ38356475
Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolismQ39193322
Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasisQ39221068
Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoterQ39233300
Repression of the promoter activity mediated by liver receptor homolog-1 through interaction with ku proteinsQ39704929
Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP).Q39716403
Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucoseQ39771613
PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 bindingQ39907196
Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.Q39964105
Mechanism, Structure, and Inhibition of O-GlcNAc Processing EnzymesQ40025244
A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptorQ40128752
The nuclear receptor LXR is a glucose sensorQ40190911
Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivationQ40324625
Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.Q40383614
SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatinQ40415650
Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.Q40555996
Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1.Q40630685
Short-term control of glucokinase activity: role of a regulatory proteinQ40745691
Mammalian glucokinase and its geneQ40855958
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in miceQ41447207
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolismQ41762089
Time-dependent pseudo-activation of hepatic glycogen synthase b by glucose 6-phosphate without involvement of protein phosphatasesQ41787570
Metabolic regulation of epigeneticsQ41942880
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stabilityQ42076002
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liverQ42128898
Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen thQ42488048
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasisQ42681991
Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytesQ43001938
Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucoseQ43003369
Expression of mRNA for glucose transport proteins in jejunum, liver, kidney and skeletal muscle of pigsQ43179086
Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylationQ43276273
Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the chlorogenic acid derivative S4048.Q43603097
Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in ratsQ43778806
Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liverQ44063015
Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis.Q44123228
Pathways for glucose disposal after meal ingestion in humansQ44244726
Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene.Q44264131
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian geneQ44264485
The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathwayQ44652125
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expressionQ44777483
Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytesQ44889088
Lxralpha deficiency hampers the hepatic adaptive response to fasting in miceQ44987000
Glycogen storage disease, types I to X: criteria for morphologic diagnosisQ45174883
Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob miceQ45187815
Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1Q45558516
Connecting threads: epigenetics and metabolismQ46493363
Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a.Q46562134
Hepatic glucose sensing via the CREB coactivator CRTC2.Q46716195
Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes.Q47701307
P433issue8
P921main subjectglycobiologyQ899224
P304page(s)1453-1467
P577publication date2013-11-07
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleHepatic glucose sensing and integrative pathways in the liver
P478volume71

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