Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

scientific article

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1008065773
P356DOI10.1186/1478-811X-9-5
P932PMC publication ID3041786
P698PubMed publication ID21299895

P50authorAnastasios LymperopoulosQ38137086
Kristy NguyenQ38137271
P2093author name stringTheodoros Kassimatis
P2860cites workEstablishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorQ24561804
Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptorsQ27867720
Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activityQ28567196
Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarctionQ33855337
Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjectsQ33867916
Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitizationQ33923585
Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype.Q33955008
Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac deathQ34171574
Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention StudyQ34340929
Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypesQ35632073
Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulationQ36991652
Chronic adrenaline treatment fails to down-regulate the Del301-303-alpha2B-adrenoceptor in neuronal cellsQ39806031
International Union of Pharmacology nomenclature of adrenoceptorsQ40638526
Subtype-specific neuronal differentiation of PC12 cells transfected with alpha2-adrenergic receptorsQ40718925
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific mannerQ41593904
Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial arteryQ44194749
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypesQ44451939
A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesityQ47691630
Alpha2B-adrenergic receptor deletion polymorphism and cardiac autonomic nervous system responses to exercise in obese women.Q54634242
An insertion/deletion polymorphism in the α2b-adrenergic receptor gene is a novel genetic risk factor for acute coronary eventsQ57303695
Physical Activity, Diet, and Incident Diabetes in Relation to an ADRA2B PolymorphismQ57403031
Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2Q67867385
G protein-coupled receptor kinasesQ77366588
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failureQ79831895
Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in menQ80590166
Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cellsQ83858428
P433issue1
P921main subjectdesensitizationQ2700499
P304page(s)5
P577publication date2011-02-07
P1433published inCell Communication and SignalingQ1254390
P1476titleImpaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells
P478volume9

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cites work (P2860)
Q38234911Adrenal adrenoceptors in heart failure.
Q36925270Association of deletion allele of insertion/deletion polymorphism in α2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus.
Q60710187Dissociable contributions of the amygdala to the immediate and delayed effects of emotional arousal on memory
Q92667871G protein-coupled receptor kinases as therapeutic targets in the heart
Q33631406GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells
Q64103561Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients
Q37981274Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown
Q33165592Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR.

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