Human antibodies to PhtD, PcpA, and Ply reduce adherence to human lung epithelial cells and murine nasopharyngeal colonization by Streptococcus pneumoniae

scientific article

Human antibodies to PhtD, PcpA, and Ply reduce adherence to human lung epithelial cells and murine nasopharyngeal colonization by Streptococcus pneumoniae is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.02124-14
P932PMC publication ID4249272
P698PubMed publication ID25245804

P2093author name stringMichael E Pichichero
Ravinder Kaur
Naveen Surendran
Martina Ochs
P2860cites workRandomized controlled study of the safety and immunogenicity of pneumococcal vaccine formulations containing PhtD and detoxified pneumolysin with alum or adjuvant system AS02V in elderly adultsQ33601853
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Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniaeQ34549615
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Pneumolysin: a double-edged sword during the host-pathogen interactionQ34824489
Nasopharyngeal antibodies to pneumococcal pneumolysin in children with acute otitis mediaQ35225029
Uptake of Streptococcus pneumoniae by respiratory epithelial cellsQ35518668
Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young childrenQ35531214
Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniaeQ35532255
Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseQ35681330
Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in miceQ35783747
Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone childrenQ35811715
Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injuryQ36018158
Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humansQ36376010
Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studiesQ36558990
Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in childrenQ36920037
Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysinQ37105935
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and diseaseQ37109940
Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilmsQ37174555
Antibodies to pneumococcal proteins PhtD, CbpA, and LytC in Filipino pregnant women and their infants in relation to pneumococcal carriageQ37213916
Surface association of Pht proteins of Streptococcus pneumoniae.Q37264619
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A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniaeQ37333825
Maternal antibodies to pneumolysin but not to pneumococcal surface protein A delay early pneumococcal carriage in high-risk Papua New Guinean infantsQ37410062
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Role of Pht proteins in attachment of Streptococcus pneumoniae to respiratory epithelial cellsQ37713234
Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adultsQ38058158
Current status and perspectives on protein-based pneumococcal vaccinesQ38124921
Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsisQ39023214
PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humansQ39314657
Relationship between phase variation in colony morphology, intrastrain variation in cell wall physiology, and nasopharyngeal colonization by Streptococcus pneumoniae.Q39825198
Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteinsQ40619089
Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniaeQ41080026
Export requirements of pneumolysin in Streptococcus pneumoniae.Q42182834
Molecular characterization of PcpA: a novel choline-binding protein of Streptococcus pneumoniaeQ42681508
Structure-guided antigen engineering yields pneumolysin mutants suitable for vaccination against pneumococcal diseaseQ42708867
Early predictors of mortality in pneumococcal bacteraemiaQ43801991
Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H.Q46275942
Biochemical Characterization of the Histidine Triad Protein PhtD as a Cell Surface Zinc-Binding Protein of PneumococcusQ57242796
Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase proteinQ67816410
Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivoQ67903731
Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniaeQ74184782
Otitis mediaQ86354303
Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine modelQ87680192
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
Streptococcus pneumoniaeQ221179
P304page(s)5069-5075
P577publication date2014-09-22
P1433published inInfection and ImmunityQ6029193
P1476titleHuman antibodies to PhtD, PcpA, and Ply reduce adherence to human lung epithelial cells and murine nasopharyngeal colonization by Streptococcus pneumoniae
P478volume82

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cites work (P2860)
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Q37309218Rationale and prospects for novel pneumococcal vaccines

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