Next generation protein based Streptococcus pneumoniae vaccines

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Next generation protein based Streptococcus pneumoniae vaccines is …
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scholarly articleQ13442814

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P356DOI10.1080/21645515.2015.1052198
P932PMC publication ID4962723
P698PubMed publication ID26539741

P2093author name stringMichael E Pichichero
M Nadeem Khan
Qingfu Xu
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New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccineQ38363735
Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsisQ39023214
Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responsesQ39037134
Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.Q39392994
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.Q39910189
Transfer of functional immunoglobulin G (IgG) antibody into the gastrointestinal tract accounts for IgG clearance in calvesQ40128510
Pneumolysin: a double-edged sword during the host-pathogen interactionQ34824489
Next generation pneumococcal vaccinesQ35028495
Dynamics of nasopharyngeal colonization by potential respiratory pathogensQ35056169
The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisitionQ35068763
Optimal serotype compositions for Pneumococcal conjugate vaccination under serotype replacementQ35097094
Lethal coinfection of influenza virus and Streptococcus pneumoniae lowers antibody response to influenza virus in lung and reduces numbers of germinal center B cells, T follicular helper cells, and plasma cells in mediastinal lymph NodeQ35115579
Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis mediaQ35132505
Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infectionQ35220396
Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infectionQ35530474
Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young childrenQ35531214
Immunological mechanisms of vaccinationQ35659533
Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseQ35681330
Differential occurrence of Streptococcus pneumoniae serotype 11E between asymptomatic carriage and invasive pneumococcal disease isolates reflects a unique model of pathogen microevolutionQ35771351
Functional antibodies elicited by two heptavalent pneumococcal conjugate vaccines in the Finnish Otitis Media Vaccine TrialQ35783918
Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone childrenQ35811715
Synchrony in serum antibody response to conserved proteins of Streptococcus pneumoniae in young childrenQ35887453
Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young childrenQ35915846
Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing countryQ36013814
Neonatal innate TLR-mediated responses are distinct from those of adults.Q36015806
Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injuryQ36018158
Nasopharyngeal colonization elicits antibody responses to staphylococcal and pneumococcal proteins that are not associated with a reduced risk of subsequent carriageQ36018177
Biochemical, genetic, and serological characterization of two capsule subtypes among Streptococcus pneumoniae Serotype 20 strains: discovery of a new pneumococcal serotypeQ36201961
Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humansQ36376010
Innate immune function by Toll-like receptors: distinct responses in newborns and the elderlyQ36511529
Nasopharyngeal bacterial interactions in childrenQ36574329
Immunogenicity, efficacy, safety and effectiveness of pneumococcal conjugate vaccines (1998-2006).Q36724239
Variation between Populations in the Innate Immune Response to Vaccine AdjuvantsQ36733384
Innate immunity of the newborn: basic mechanisms and clinical correlatesQ36800979
Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in childrenQ36920037
Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniaeQ37111830
CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigensQ37184360
Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in miceQ37241352
CD4 T cell memory and antibody responses directed against the pneumococcal histidine triad proteins PhtD and PhtE following nasopharyngeal colonization and immunization and their role in protection against pneumococcal colonization in miceQ37264678
Animal models of Streptococcus pneumoniae diseaseQ37293669
IL-22 and inflammation: leukin' through a glass onionQ37328260
P433issue1
P921main subjectStreptococcus pneumoniaeQ221179
P304page(s)194-205
P577publication date2015-11-05
P1433published inHuman Vaccines & ImmunotherapeuticsQ21072749
P1476titleNext generation protein based Streptococcus pneumoniae vaccines
P478volume12

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cites work (P2860)
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