The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication

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The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.03328-14
P932PMC publication ID4249361
P698PubMed publication ID25199773
P5875ResearchGate publication ID265473293

P50authorRolf HilgenfeldQ28039171
Johan NeytsQ29460378
Pieter LeyssenQ29460394
Mathy FroeyenQ114401432
Aloys TijsmaQ114401435
P2093author name stringSimon Tucker
David Franco
P2860cites workActivity of pleconaril against enterovirusesQ24550640
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypesQ27619756
3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against PicornavirusesQ27676219
More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding moleculesQ27681644
Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trialsQ28178690
In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activityQ28343180
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinovirusesQ30306034
Treatment of potentially life-threatening enterovirus infections with pleconarilQ31918011
Hand, foot, and mouth disease in China, 2008-12: an epidemiological studyQ33668897
Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trialQ34347924
Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replicationQ36387676
Potential use of antiviral agents in polio eradicationQ36944919
In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infectionQ39412134
Towards the design of combination therapy for the treatment of enterovirus infectionsQ39564162
In vitro and in vivo characterization of a new enterovirus type 71-specific human intravenous immunoglobulin manufactured from selected plasma donorsQ39742772
An inactivated enterovirus 71 vaccine in healthy childrenQ40216677
Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatmentQ40375873
Enterovirus 71 meningoencephalitis during chemotherapy in a child with metastatic osteosarcomaQ40440541
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitorsQ40740581
Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in ChinaQ42226974
The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathwaysQ42524022
An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirusQ43617763
Inhibition of Rhinovirus Replication in Organ Culture by a Potential Antiviral DrugQ44124666
Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitisQ44400134
Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility.Q54132214
Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazolesQ56786343
Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth diseaseQ73198212
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)6990-6992
P577publication date2014-09-08
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleThe capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication
P478volume58