Erythropoietin after a century of research: younger than ever

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Erythropoietin after a century of research: younger than ever is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1600-0609.2007.00818.X
P698PubMed publication ID17253966
P5875ResearchGate publication ID6550109

P50authorWolfgang JelkmannQ114451997
P2860cites workEfficiency of signalling through cytokine receptors depends critically on receptor orientationQ22003959
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alphaQ24291726
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationQ24291783
A conserved family of prolyl-4-hydroxylases that modify HIFQ24291794
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activityQ24291819
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activationQ24294741
Isolation and characterization of genomic and cDNA clones of human erythropoietinQ24299960
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factorQ24300161
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803Q24306213
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive elementQ24528175
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasisQ24536498
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylationQ24555773
Cloning and expression of the human erythropoietin geneQ24608978
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayQ24672316
Cobalt chloride administration in athletes: a new perspective in blood doping?Q24672328
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular developmentQ24681396
Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 AQ27732820
NMR structure of human erythropoietin and a comparison with its receptor bound conformationQ27765719
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activationQ27766884
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factorQ28118068
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylationQ28188357
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switchQ28217194
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signalsQ28236222
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietinQ28260976
Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositisQ36507323
The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1.Q36550495
Inhibition of erythropoietin signalling destroys xenografts of ovarian and uterine cancers in nude miceQ36622808
Redox regulation of the hypoxia-inducible factorQ36642721
The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5' flanking regionQ36785443
Small peptides as potent mimetics of the protein hormone erythropoietinQ36802815
Glycopeptide profiling of human urinary erythropoietin by matrix-assisted laser desorption/ionization mass spectrometryQ36884402
Expression of the erythropoietin geneQ36917476
Anemia induces accumulation of erythropoietin mRNA in the kidney and liverQ36918011
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injuryQ37250532
Chromosomal assignment of the human erythropoietin gene and its DNA polymorphismQ37399458
Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitroQ37481031
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin geneQ37541263
Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptorQ37571920
Specific binding of erythropoietin to spleen cells infected with the anemia strain of Friend virusQ37579303
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic miceQ37601187
Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietinQ38294090
Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic diseaseQ38337379
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vesselsQ38346980
Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA.Q38355340
Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactionsQ38360226
Involvement of Ca2+-independent phospholipase A2 in the translocation of hypoxia-inducible factor-1alpha to the nucleus under hypoxic conditionsQ40231221
Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP).Q40351752
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intactQ40411510
Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachmentQ40434711
Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bondQ40436923
Is the renal production of erythropoietin controlled by the brain stem?Q40443345
Myelodysplastic syndrome.Q40452972
Chemosensitization by erythropoietin through inhibition of the NF-kappaB rescue pathwayQ40484626
GATA-1 transactivates erythropoietin receptor gene, and erythropoietin receptor-mediated signals enhance GATA-1 gene expressionQ40505328
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.Q40563648
Effect of haemopoietic growth factors on cancer cell lines and their role in chemosensitivityQ40612658
The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygenQ40631949
Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis proteinQ40671839
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneysQ40721597
Structural analysis of sulfated N-linked oligosaccharides in erythropoietinQ40755704
Erythropoietin mimetics derived from solution phase combinatorial librariesQ40755835
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chainQ40795310
Low doses of EPO activate MAP kinases but not JAK2-STAT5 in rat vascular smooth muscle cellsQ40798013
Erythropoietin receptor expression in human melanoma cellsQ40839975
A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradationQ40941866
How to diagnose and correct iron deficiency during r-huEPO therapy--a consensus reportQ41009226
Erythropoietin upregulates the expression of its own receptor in TF-1 cell lineQ41041874
Gene transfer for erythropoiesis enhancementQ41105474
The effect of human recombinant erythropoietin on the growth of a human neuroblastoma cell lineQ41250615
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme proteinQ41337564
Erythropoietin therapyQ41384536
Retinoic acid up-regulates erythropoietin production in hepatoma cells and in vitamin A-depleted ratsQ41450278
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elementsQ41591510
Demonstration of high levels of erythropoietin in rat kidneys following hypoxic hypoxiaQ41640743
The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptorQ41659068
Role of cytochrome P450 in the control of the production of erythropoietinQ41752741
Enhancement of heme and globin synthesis in cultured human marrow by certain 5 -H steroid metabolitesQ42023813
Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cellsQ42435444
Human erythropoietin gene: high level expression in stably transfected mammalian cells and chromosome localizationQ36458416
Regulation of HIF prolyl hydroxylases by hypoxia-inducible factorsQ28262857
Normalization of hemoglobin level in patients with chronic kidney disease and anemiaQ28274269
Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cellsQ28282130
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1Q28282227
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathwaysQ28287538
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunitQ28298336
A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4Q28362273
Development and characterization of novel erythropoiesis stimulating protein (NESP)Q28362976
Purification and characterization of hypoxia-inducible factor 1Q28678375
Mitochondrial reactive oxygen species trigger hypoxia-induced transcriptionQ29614203
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau proteinQ29615928
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changesQ29617594
Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometryQ30404030
New erythropoietic proteins: rationale and clinical dataQ30936857
Involvement of erythropoietin-induced cytosolic free calcium mobilization in activation of mitogen-activated protein kinase and DNA synthesis in vascular smooth muscle cellsQ32048225
The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motifQ32138809
Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathwayQ33180653
Novel strategies for stimulating erythropoiesis and potential new treatments for anaemiaQ33256941
Recombinant human thrombopoietin: basic biology and evaluation of clinical studiesQ33345058
La pression barométrique: Paul Bert's hypoxia theory and its criticsQ33472283
New epoetin molecules and novel therapeutic approachesQ33639214
Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cellsQ33730124
Healthcare systems. An international review. IntroductionQ33755437
Signal transduction in the erythropoietin receptor systemQ33783537
Adaptation and conservation of physiological systems in the evolution of human hypoxia toleranceQ33799537
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascadesQ34086191
Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethalityQ34150075
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemiaQ34157665
Enhancement of therapeutic protein in vivo activities through glycoengineeringQ34180647
Role of the kidney in erythropoiesisQ34241097
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin productionQ34248310
A direct measurement of the radiation sensitivity of normal mouse bone marrow cellsQ34249472
Carbon Monoxide: a Putative Neural MessengerQ34305648
Oxygen-dependent and tissue-specific regulation of erythropoietin gene expressionQ34320660
Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal deathQ34411455
A potential role for erythropoietin in focal permanent cerebral ischemia in mice.Q42473313
Proteasomes regulate the duration of erythropoietin receptor activation by controlling down-regulation of cell surface receptorsQ42489065
Erythropoietin gene expression in different areas of the developing human central nervous system.Q42498375
Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinomaQ42525531
A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activationQ42646877
Lack of sex dependence of the serum level of immunoreactive erythropoietin in chronic anemiaQ43476959
Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivoQ43627722
The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled studyQ43636269
Genetic heterogeneity of primary familial and congenital polycythemiaQ43739634
Increased expression of erythropoiesis inhibiting cytokines (IFN-gamma, TNF-alpha, IL-10, and IL-13) by T cells in patients exhibiting a poor response to erythropoietin therapyQ44486191
Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levelsQ44534261
Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failureQ44948985
Human erythropoietin gene therapy for patients with chronic renal failureQ45044565
Progress in the purfication of erythropoietinQ45224760
Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell SurvivalQ46044225
Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxiaQ46315752
Biophysical comparability of the same protein from different manufacturers: a case study using Epoetin alfa from Epogen and EprexQ46325365
Effects of chemotherapy on endogenous erythropoietin levels and the pharmacokinetics and erythropoietic response of darbepoetin alfa: a randomised clinical trial of synchronous versus asynchronous dosing of darbepoetin alfaQ46505300
The prolonged half-lives of new erythropoietin derivatives via peptide additionQ46824865
Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interactionQ46931184
Derivatives of erythropoietin that are tissue protective but not erythropoieticQ47213815
Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathwayQ47612450
Evidence for an erythropoietin receptor protein on rat bone marrow cellsQ47869159
Erythroid colony formation in cultures of mouse and human bone marrow: Analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose-concanavalin AQ47878288
Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblastsQ47951521
The effects of higher hemoglobin levels on mortality and hospitalization in hemodialysis patientsQ47993808
Immunohistochemical localization of erythropoietin and its receptor in the developing human brainQ48289607
Immunolocalization of erythropoietin and erythropoietin receptor in vestibular schwannomaQ48882565
Erythropoietin gene expression in human, monkey and murine brainQ49015563
La pression barométrique : recherches de physiologie expérimentaleQ51379863
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.Q51614218
Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis.Q51639478
Hepatic erythropoietin gene regulation by GATA-4.Q52098524
Where does preoperative erythropoietin therapy count? A mathematical perspective.Q52216732
Studies on the role of recombinant human erythropoietin in the growth regulation of human nonhematopoietic tumor cells in vitro.Q53029316
Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure.Q53399782
Erythropoietin: a somewhat personal history.Q53631173
Erythropoietin regulates endothelial progenitor cellsQ53854344
Phosphatidylserine exposure in B lymphocytes: a role for lipid packingQ57374987
Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilizationQ58816341
Bio-Assay of Erythropoietin in Mice Made PolycythÆmic by Exposure to Air at a Reduced PressureQ59092001
2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guidelineQ34523108
Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers.Q34529820
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodelingQ34960679
Characterization of an erythroid precursor cell of high proliferative capacity in normal human peripheral bloodQ35011782
Functional erythropoietin autocrine loop in melanomaQ35083677
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.Q35144156
Anemia management and the delay of chronic renal failure progressionQ35159401
Erythropoietin receptor mRNA expression in human endothelial cellsQ35208338
Expression cloning of the murine erythropoietin receptorQ35416452
The cardiovascular effects of erythropoietinQ35538417
EORTC Cancer in the Elderly Task Force guidelines for the use of colony-stimulating factors in elderly patients with cancerQ35558558
Epoetin alfa. Clinical evolution of a pleiotropic cytokineQ35652564
The molecular mechanism of erythropoietin actionQ35657845
Role of apoptosis in reperfusion injuryQ35666886
HIFs and tumors--causes and consequencesQ35683703
Mimicry of erythropoietin by a nonpeptide moleculeQ35735812
Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progressionQ35791446
Human erythropoietin dimers with markedly enhanced in vivo activityQ35799107
An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection.Q35833911
Beneficial and ominous aspects of the pleiotropic action of erythropoietinQ35868143
Our ancestral physiological phenotype: an adaptation for hypoxia tolerance and for endurance performance?Q35895956
Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.Q35954913
Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathwaysQ35997721
Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disordersQ36050619
Effects of erythropoietin on brain functionQ36052901
Granulocyte and granulocyte-macrophage colony-stimulating factors in allografts: uses, misuses, misconceptions, and future applicationsQ36105780
Cost-effectiveness of recombinant human erythropoietin in the prevention of chemotherapy-induced anaemiaQ36115014
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanismQ36174439
Biosimilar epoetins: an analysis based on recently implemented European medicines evaluation agency guidelines on comparability of biopharmaceutical proteinsQ36188312
The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systemsQ36335414
Human erythroid burst-forming unit: T-cell requirement for proliferation in vitroQ36340694
Evidence-based systematic literature review of hemoglobin/hematocrit and all-cause mortality in dialysis patientsQ36353302
Erythropoietin biology in cancer.Q36374675
Use of G-CSF in matched sibling donor pediatric allogeneic transplantation: a consensus statement from the Children's Oncology Group (COG) Transplant Discipline Committee and Pediatric Blood and Marrow Transplant Consortium (PBMTC) Executive CommittQ36389445
P433issue3
P921main subjecterythropoietinQ218706
P304page(s)183-205
P577publication date2007-01-23
P1433published inEuropean Journal of HaematologyQ15765799
P1476titleErythropoietin after a century of research: younger than ever
P478volume78

Reverse relations

cites work (P2860)
Q59138064A Randomized Controlled Trial: Regenerative Effects, Efficacy and Safety of Erythropoietin in Burn and Scalding Injuries
Q51148340A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.
Q44492451A mouse model of adult-onset anaemia due to erythropoietin deficiency.
Q36843227A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial
Q33557851A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia
Q84514246Acute short-term hyperoxia followed by mild hypoxia does not increase EPO production: resolving the "normobaric oxygen paradox"
Q41820057An extra high dose of erythropoietin fails to support the proliferation of erythropoietin dependent cell lines
Q35836904Anaemia in kidney disease: harnessing hypoxia responses for therapy
Q37258782Anemia and the potential role of erythropoiesis-stimulating agents in heart failure
Q34017043Anemia upregulates lipocalin 2 in the liver and serum.
Q51540635Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.
Q37130139Approaches to the treatment of anaemia in patients with chronic heart failure
Q37999380Biosimilar recombinant human erythropoietins ("epoetins") and future erythropoiesis-stimulating treatments
Q33649999Blood cells RNA biomarkers as a first long-term detection strategy for EPO abuse in horseracing.
Q36733103CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia
Q42722918Carbamylated Erythropoietin Outperforms Erythropoietin in the Treatment of AKI-on-CKD and Other AKI Models
Q54428734Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6.
Q42485540Cobalt uptake and binding in human red blood cells
Q50558097Confirmatory Analysis of Continuous Erythropoietin Receptor Activator and Erythropoietin Analogues in Equine Plasma by LC−MS for Doping Control
Q37212727Congenital erythrocytosis associated with gain-of-function HIF2A gene mutations and erythropoietin levels in the normal range
Q36999068Control of erythropoietin gene expression and its use in medicine
Q96302126Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?
Q39701797Covering a broad dynamic range: information processing at the erythropoietin receptor
Q37989124Detection of EPO doping and blood doping: the haematological module of the Athlete Biological Passport
Q26777810Diverse of Erythropoiesis Responding to Hypoxia and Low Environmental Temperature in Vertebrates
Q98895939Dual Switch Mechanism of Erythropoietin as an Antiapoptotic and Pro-Angiogenic Determinant in the Retina
Q36677326EPO receptor circuits for primary erythroblast survival
Q42003728EV-3, an endogenous human erythropoietin isoform with distinct functional relevance
Q56974507Effects of Erythropoietin on Frataxin Levels and Mitochondrial Function in Friedreich Ataxia – a Dose–Response Trial
Q48365906Effects of erythropoietin on blood-brain barrier tight junctions in ischemia-reperfusion rats
Q37784333Effects of recombinant human erythropoietin in normal humans
Q27010635Efficacy and Safety of Erythropoietin to Prevent Acute Kidney Injury in Patients With Critical Illness or Perioperative Care: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Q48092428Endogenous brain erythropoietin is a potent sex-specific respiratory stimulant in adult and newborn mice
Q36800398Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis
Q33791317Epo is relevant neither for microvascular formation nor for the new formation and maintenance of mice skeletal muscle fibres in both normoxia and hypoxia
Q36928937Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation
Q33829114Erythrocytosis associated with a novel missense mutation in the HIF2A gene
Q24309788Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline
Q34127573Erythropoiesis and Iron Sulfur Cluster Biogenesis
Q35176135Erythropoietin (EPO) in acute kidney injury
Q47360067Erythropoietin Attenuates the Brain Edema Response after Experimental Traumatic Brain Injury
Q50606157Erythropoietin activates nitric oxide synthase in murine erythrocytes.
Q41855459Erythropoietin administration partially prevents adipose tissue loss in experimental cancer cachexia models
Q34063671Erythropoietin ameliorates rat experimental autoimmune neuritis by inducing transforming growth factor-β in macrophages
Q39005050Erythropoietin and co.: intrinsic structure and functional disorder
Q48312143Erythropoietin as Additive of HTK Preservation Solution in Cold Ischemia/Reperfusion Injury of Steatotic Livers
Q92877211Erythropoietin as a Neuroprotective Molecule: An Overview of Its Therapeutic Potential in Neurodegenerative Diseases
Q34544348Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways
Q34017654Erythropoietin levels are not independently associated with malaria-attributable severe disease in Mozambican children
Q83917078Erythropoietin levels in endocrinopathies
Q42532323Erythropoietin modulates the structure of bone morphogenetic protein 2-engineered cranial bone
Q37968179Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy
Q45267182Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis
Q40457957Erythropoietin receptor (EpoR) agonism is used to treat a wide range of disease.
Q39250670Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells
Q42928249Erythropoietin reverses the attentional set-shifting impairment in a rodent schizophrenia disease-like model
Q41822845Erythropoietin use and abuse
Q34502176Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2
Q42922791Erythropoietin: a multimodal neuroprotective agent
Q42972651Erythropoietin: when liability becomes asset in neurovascular repair
Q34182011Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects
Q33862002Evidence of receptor-mediated elimination of erythropoietin by analysis of erythropoietin receptor mRNA expression in bone marrow and erythropoietin clearance during anemia.
Q55252265Generation of transgenic chickens expressing the human erythropoietin (hEPO) gene in an oviduct-specific manner: Production of transgenic chicken eggs containing human erythropoietin in egg whites.
Q34203463Glucose, insulin, and oxygen interplay in placental hypervascularisation in diabetes mellitus.
Q33926530HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism
Q35138319Hematological parameters, and hematopoietic growth factors: EPO and IL-3 in response to whole-body cryostimulation (WBC) in military academy students
Q38262836High-dose erythropoietin for tissue protection
Q38882599Hypometabolism as the ultimate defence in stress response: how the comparative approach helps understanding of medically relevant questions
Q42147890Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
Q24609166Hypoxic regulation of erythropoiesis and iron metabolism
Q50454067Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.
Q33389236Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care?
Q47634204Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings.
Q40825620Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice
Q37818329Intranasal erythropoietin therapy in nervous system disorders
Q27317145Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice
Q28075747Lung Structure and the Intrinsic Challenges of Gas Exchange
Q35064235MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms
Q47109963NCOR1 modulates erythroid disorders caused by mutations of thyroid hormone receptor α1.
Q50042158Neuroprotective Effects of neuroEPO Using an In Vitro Model of Stroke
Q37510763Neuroprotective role of erythropoietin by antiapoptosis in the retina.
Q38896197Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations
Q37254556Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing.
Q38791521Novel bioluminescent binding assays for interaction studies of protein/peptide hormones with their receptors
Q36845732Novel opportunities for computational biology and sociology in drug discovery
Q37385426Novel opportunities for computational biology and sociology in drug discovery.
Q33620938Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis.
Q37946499Organ-protective and immunomodulatory effects of erythropoietin--an update on recent clinical trials
Q38848944Probing protease sensitivity of recombinant human erythropoietin reveals α3-α4 inter-helical loop as a stability determinant.
Q24633871Production of therapeutic proteins in algae, analysis of expression of seven human proteins in the chloroplast of Chlamydomonas reinhardtii
Q48040213Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes
Q37390664Protein profile analysis of the breast microenvironment to differentiate healthy women from breast cancer patients
Q41173431Recombinant Human Erythropoietin: Novel Strategies for Neuroprotective/Neuro-regenerative Treatment of Multiple Sclerosis
Q35356050Recombinant erythropoietin in humans has a prolonged effect on circulating erythropoietin isoform distribution
Q43099001Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis
Q37063716Regulation of erythropoiesis by hypoxia-inducible factors
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