Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways

scientific article

Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1159/000081963
P698PubMed publication ID15627815

P50authorKenneth MaieseQ85354857
P2093author name stringZhao Zhong Chong
Faqi Li
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Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilizationQ58816341
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
Isolation and characterization of genomic and cDNA clones of human erythropoietinQ24299960
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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinaseQ24314333
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayQ24672316
Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecinQ24795283
Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease miceQ24795623
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
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Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45Q28199142
Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cellsQ28207530
PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisQ28207557
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The CARD domain: a new apoptotic signalling motifQ28239887
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JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietinQ28260976
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Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activityQ28511401
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Erythropoietin depresses nitric oxide synthase expression by human endothelial cellsQ41614432
A potential role for erythropoietin in focal permanent cerebral ischemia in mice.Q42473313
Proteasomes regulate the duration of erythropoietin receptor activation by controlling down-regulation of cell surface receptorsQ42489065
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Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.Q43718523
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Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injuryQ43994231
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell lossQ44005958
Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolismQ44117700
Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteasesQ44235661
The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous erythropoietin and intravenous ironQ44248272
NF-kappaB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expressionQ44249433
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Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8.Q44313658
Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietinQ44351055
Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptorsQ44419297
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Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activationQ44550608
Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: effect on lipid peroxidation and early ultrastructural findings.Q44550966
Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activityQ44586804
Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channelsQ44847078
Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cellsQ44865870
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient miceQ44904989
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal deathQ44932646
Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's diseaseQ45299150
Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia-ischemia ratsQ45872114
Nitric oxide metabolism in erythropoietin-induced hypertension: effect of calcium channel blockade.Q45993079
Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in ratsQ47285421
Changes in left ventricular size, wall thickness, and function in anemic patients treated with recombinant human erythropoietinQ47409026
Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathwayQ47612450
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injuryQ47849035
Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblastsQ47951521
Blood pressure response to erythropoietin injection in hemodialysis and predialysis patientsQ47989471
Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathwayQ48027372
Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability.Q48144017
Lithium protects cultured neurons against beta-amyloid-induced neurodegenerationQ48163930
Protective effect of erythropoietin in neonatal hypoxic ischemia in miceQ48187195
Effects of erythropoietin on neuronal activityQ48198090
Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral arteryQ48316192
Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neuronsQ48371815
Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in miceQ48411161
Erythropoietin exerts anti-apoptotic effects on rat microglial cells in vitro.Q48482743
Regulated human erythropoietin receptor expression in mouse brainQ48558987
AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9Q28572052
Akt1 regulates a JNK scaffold during excitotoxic apoptosisQ28574706
Erythropoietin and bone morphogenetic protein 7 mediate ascorbate-induced dopaminergic differentiation from embryonic mesencephalic precursorsQ28575350
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase BQ28638147
Purification and characterization of hypoxia-inducible factor 1Q28678375
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
Mechanisms of angiogenesisQ29547485
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationQ29618715
Effect of active oxygen radicals on protein and carbohydrate moieties of recombinant human erythropoietinQ30428753
Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in ratsQ30480727
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line.Q30628127
Chemical hypoxia-ischemia induces apoptosis in cerebromicrovascular endothelial cellsQ30924971
Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathwayQ33180653
Erythropoietin and VEGF exhibit equal angiogenic potentialQ33184235
Serine/threonine protein kinases and apoptosis.Q33876765
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeQ33912989
Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhageQ34025786
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascadesQ34086191
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblastsQ34102833
Pleckstrin homology domains and the cytoskeletonQ34120310
Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascadesQ34125272
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degenerationQ34133712
Apoptosis in Alzheimer's disease--an updateQ34167413
Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell EngulfmentQ34189926
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.Q34206288
Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injuryQ34265287
Apoptosis-regulating proteins as targets for drug discoveryQ34293102
Caspase activation: revisiting the induced proximity modelQ34328287
Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal deathQ34411455
Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6.Q34446220
Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemiaQ34464630
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodelingQ34960679
Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.Q35029780
Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathwaysQ35045115
Intussusceptive angiogenesis--the alternative to capillary sproutingQ35049601
Angiogenesis and plasticity: role of erythropoietin in vascular systemsQ35067897
Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brainQ35136318
Erythropoietin: cytoprotection in vascular and neuronal cellsQ35137453
Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's diseaseQ35557675
Epoetin alfa. Clinical evolution of a pleiotropic cytokineQ35652564
Erythropoietin in cardiovascular diseases.Q35676092
Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous systemQ35693451
Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancerQ35699270
Protective effect of heat shock proteins in the nervous systemQ36266071
Molecular targets to promote central nervous system regenerationQ36266089
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrityQ36324207
Akt regulates cell survival and apoptosis at a postmitochondrial levelQ36342570
Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosisQ36371706
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cellsQ36380062
In vivo evidence that erythropoietin protects neurons from ischemic damageQ36477827
Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degenerationQ37273048
Activation and inhibition of erythropoietin receptor function: role of receptor dimerizationQ38307491
Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesisQ38333334
The role of carbohydrate in recombinant human erythropoietinQ38341593
Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA.Q38355340
Comparative structural study of N-linked oligosaccharides of urinary and recombinant erythropoietinsQ39104192
The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potentialQ40498088
Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase: role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinaseQ40580653
Erythropoietin protects the developing brain against N-methyl-D-aspartate receptor antagonist neurotoxicityQ40581068
Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemiaQ40637230
Fractalkine and fractalkine receptors in human neurons and glial cellsQ40717328
Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.Q40767950
The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosisQ40791166
cDNA cloning and functional analysis of a truncated STAT5a protein from autonomously growing FDCP-1 cellsQ40832916
Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts.Q40854129
Protein kinase C alpha controls erythropoietin receptor signalingQ40862162
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosisQ40944401
Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: sequential activation of caspases 8, 3, and 1 in the apoptotic processQ40948570
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosisQ41008797
P433issue6
P921main subjecterythropoietinQ218706
P304page(s)265-289
P577publication date2004-11-01
P1433published inNeuroSignalsQ15758810
P1476titleErythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways
P478volume13

Reverse relations

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