Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.

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Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI29709
P932PMC publication ID1770947
P698PubMed publication ID17256056

P50authorTamar R AprahamianQ39361982
Kenneth WalshQ42730508
Michael T KirberQ43008273
P2093author name stringRei Shibata
Noriyuki Ouchi
Shinji Kihara
Yukihiro Takemura
Ross S Summer
P2860cites workAdiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophagesQ24290146
Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsQ24304889
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectinQ24564272
C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cellsQ24670661
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Q28511676
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyteQ29615441
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesityQ29616103
Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signalingQ31056825
Adiponectin-mediated modulation of hypertrophic signals in the heartQ33688678
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanismsQ33688706
Identification of amino-terminal region of adiponectin as a physiologically functional domainQ82242830
Interaction of mutant lpr gene with background strain influences renal diseaseQ93612765
A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivoQ33912964
Phagocytosis and clearance of apoptotic cells is mediated by MER.Q33946282
A blast from the past: clearance of apoptotic cells regulates immune responses.Q34162195
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).Q34377772
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in miceQ35108391
Obesity, adiponectin and vascular inflammatory diseaseQ35587168
Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts.Q35757313
Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokinesQ35786203
Immunoregulatory functions of surfactant proteinsQ35998804
A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?Q36081354
TNF pathophysiology in murine models of chronic inflammation and autoimmunity.Q36106345
Adipose tissue, inflammation, and cardiovascular diseaseQ36125401
Abnormalities induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/J mice homozygous and heterozygous for lpr.Q36349884
Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune diseaseQ36399434
Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complexQ39750562
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetesQ40892075
Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophagesQ42117845
Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response.Q42231394
AdipoQ is a novel adipose-specific gene dysregulated in obesityQ42813232
Adiponectin and protection against type 2 diabetes mellitusQ44290932
Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian.Q44453195
Decreased plasma adiponectin concentrations in women with low-grade C-reactive protein elevationQ44457586
Increased single-nephron protein excretion after renal ablation in nephrotic ratsQ46433944
Human adiponectin binds to bacterial lipopolysaccharideQ46907520
Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophagesQ47735588
Association between adiponectin and mediators of inflammation in obese women.Q48007188
Decreased phagocytosis of apoptotic cells in diseased SLE miceQ48029935
Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue.Q54790389
Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and an Impaired Clearance of Apoptotic CellsQ57089503
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodiesQ57089602
Immunosuppressive effects of apoptotic cellsQ59060221
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient miceQ64378290
Lipopolysaccharide induces rapid production of IL-10 by monocytes in the presence of apoptotic neutrophilsQ77584477
Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cellsQ80416626
Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese menQ81570063
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
apoptotic processQ14599311
P304page(s)375-386
P577publication date2007-01-25
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleAdiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
P478volume117

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