Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets

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Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/CARCIN/BGM054
P698PubMed publication ID17372274
P5875ResearchGate publication ID6435659

P50authorYoung-Joon SurhQ91713697
P2093author name stringHye-Kyung Na
Jung-Chul Lee
Joydeb K Kundu
Dal-Mi Hwang
P2860cites workIkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domainQ22010650
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytesQ24815106
Missing pieces in the NF-kappaB puzzleQ29547864
Cancer chemoprevention with dietary phytochemicalsQ29617743
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
The role of cyclooxygenases in inflammation, cancer, and developmentQ33814331
Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoidQ33886297
Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesisQ34156486
Antioxidative activity of hop bitter acids and their analoguesQ34312388
Signal transduction events elicited by cancer prevention compoundsQ34338131
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activationQ34338138
Role of the BMK1/ERK5 signaling pathway: lessons from knockout miceQ34363614
Many actions of cyclooxygenase-2 in cellular dynamics and in cancerQ34539982
Cyclooxygenase isozymes and their gene structures and expressionQ34997933
Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4.Q35043768
Cyclooxygenase 2: a molecular target for cancer prevention and treatmentQ35057356
Carcinogenesis and cyclooxygenase: the potential role of COX-2 inhibition in upper aerodigestive tract cancerQ35150445
Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemopreventionQ35864033
At the crossroads of inflammation and cancerQ35888450
Inflammation as a tumor promoter in cancer inductionQ35920466
Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventivesQ36059834
Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effectsQ36145133
Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicalsQ36231320
Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytesQ40393266
IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharideQ40646108
Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptorQ40703003
Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissuesQ41004291
Apoptosis to HL-60 by HumuloneQ41107102
Inhibition of angiogenesis by humulone, a bitter acid from beer hop.Q43799505
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.Q43815830
Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activationQ44502542
Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skinQ44732799
Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.Q45216404
[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skinQ45286157
Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activityQ46941211
Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.Q53465478
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
(+)-humuloneQ419456
P304page(s)1491-1498
P577publication date2007-03-19
P1433published inCarcinogenesisQ326022
P1476titleHumulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets
P478volume28

Reverse relations

cites work (P2860)
Q35741600Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth
Q38117195Beer and beer compounds: physiological effects on skin health
Q34591937Curcumin decreases 12-O-tetradecanoylphorbol-13-acetate-induced protein kinase C translocation to modulate downstream targets in mouse skin
Q34360927Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia
Q46096656EGFR-mediated Akt and MAPKs signal pathways play a crucial role in patulin-induced cell proliferation in primary murine keratinocytes via modulation of Cyclin D1 and COX-2 expression
Q42833606Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term
Q64257126Hop Compounds: Extraction Techniques, Chemical Analyses, Antioxidative, Antimicrobial, and Anticarcinogenic Effects
Q51378677Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro.
Q42276358Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells
Q47099602Lippia origanoides extract induces cell cycle arrest and apoptosis and suppresses NF-κB signaling in triple-negative breast cancer cells
Q37137675Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells
Q37686669New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals: In Vitro and In Vivo Studies and the Underlying Mechanisms
Q42714145Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1.
Q51102871Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1.
Q31071791Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice
Q33383634Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.
Q30383660Tetrahydro-iso-alpha Acids Antagonize Estrogen Receptor Alpha Activity in MCF-7 Breast Cancer Cells

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