Mapping the inner workings of the microbiome: genomic- and metagenomic-based study of metabolism and metabolic interactions in the human microbiome

scientific article

Mapping the inner workings of the microbiome: genomic- and metagenomic-based study of metabolism and metabolic interactions in the human microbiome is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CMET.2014.07.021
P932PMC publication ID4252837
P698PubMed publication ID25176148

P50authorRoie LevyQ83769861
Elhanan BorensteinQ107185090
P2093author name stringOhad Manor
P2860cites workWhole genome amplification and de novo assembly of single bacterial cellsQ21142771
Environments that induce synthetic microbial ecosystemsQ21563487
The complete genome sequence for putative H₂- and S-oxidizer Candidatus Sulfuricurvum sp., assembled de novo from an aquifer-derived metagenomeQ42648414
Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environmentsQ42743118
Genome resolved analysis of a premature infant gut microbial community reveals a Varibaculum cambriense genome and a shift towards fermentation-based metabolism during the third week of lifeQ42918686
Genovo: de novo assembly for metagenomesQ46842122
The microbiome as a human organ.Q55056198
A Genomic View of the Human-Bacteroides thetaiotaomicron SymbiosisQ22065827
Insights into the phylogeny and coding potential of microbial dark matterQ24490632
Obesity alters gut microbial ecologyQ24531503
The gut flora as a forgotten organQ24550824
Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic miceQ24568168
A human gut microbial gene catalogue established by metagenomic sequencingQ24618931
A whole-cell computational model predicts phenotype from genotypeQ24622101
Metagenomic analysis of the human distal gut microbiomeQ24633486
Microbial community gene expression in ocean surface watersQ24651959
Identifying bacterial genes and endosymbiont DNA with GlimmerQ24653724
Global reconstruction of the human metabolic network based on genomic and bibliomic dataQ24677060
Metagenomics for studying unculturable microorganisms: cutting the Gordian knotQ24811165
Computational meta'omics for microbial community studiesQ26825114
An obesity-associated gut microbiome with increased capacity for energy harvestQ27860515
Microbial ecology: human gut microbes associated with obesityQ27861004
The gut microbiota as an environmental factor that regulates fat storageQ28131676
Metabolic network structure determines key aspects of functionality and regulationQ28214885
Programmable bacteria detect and record an environmental signal in the mammalian gutQ28236112
Using the topology of metabolic networks to predict viability of mutant strainsQ28246806
What is flux balance analysis?Q28275348
Microbial co-occurrence relationships in the human microbiomeQ28481283
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatmentQ28710518
Microdroplet-enabled highly parallel co-cultivation of microbial communitiesQ28742380
Population genomic analysis of strain variation in Leptospirillum group II bacteria involved in acid mine drainage formationQ28757646
APE: Analyses of Phylogenetics and Evolution in R languageQ29546513
KEGG for integration and interpretation of large-scale molecular data setsQ29547277
Diet rapidly and reproducibly alters the human gut microbiomeQ29547454
The large-scale organization of metabolic networksQ29547498
Community structure and metabolism through reconstruction of microbial genomes from the environmentQ29547528
Prodigal: prokaryotic gene recognition and translation initiation site identificationQ29547611
A metagenome-wide association study of gut microbiota in type 2 diabetesQ29547726
Comparative metagenomics of microbial communitiesQ29555844
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humansQ29614455
Gut microbiota from twins discordant for obesity modulate metabolism in miceQ29614796
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequencesQ29615050
The vaginal microbiome in health and diseaseQ35243537
Metabolic modeling of a mutualistic microbial community.Q35742362
Predicting a human gut microbiota's response to diet in gnotobiotic miceQ35829905
Soil metaproteomics - Comparative evaluation of protein extraction protocols.Q36147433
MetaVelvet: an extension of Velvet assembler to de novo metagenome assembly from short sequence readsQ36368703
Xenobiotics shape the physiology and gene expression of the active human gut microbiomeQ36554412
Systems-level characterization of a host-microbe metabolic symbiosis in the mammalian gutQ36564712
The evolution of modularity in bacterial metabolic networks.Q36657624
Large-scale reconstruction and phylogenetic analysis of metabolic environmentsQ36936268
Defined spatial structure stabilizes a synthetic multispecies bacterial communityQ36984976
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phylaQ37138595
Rules of engagement: interspecies interactions that regulate microbial communitiesQ37187806
The gastrointestinal microbiota as a site for the biotransformation of drugsQ37235756
Metabolic-network-driven analysis of bacterial ecological strategiesQ37282861
Spatial self-organization favors heterotypic cooperation over cheatingQ37295444
Mighty small: Observing and modeling individual microbes becomes big science.Q37318089
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolismQ37318311
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut.Q37406127
Computational deconvolution: extracting cell type-specific information from heterogeneous samplesQ37417280
Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineageQ37425722
Bacterial colonization factors control specificity and stability of the gut microbiotaQ37483694
Sense from sequence reads: methods for alignment and assemblyQ37618545
Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysisQ37627585
Web of ecological interactions in an experimental gut microbiotaQ37756238
Strategies for culture of 'unculturable' bacteriaQ37757054
The oral microbiome in health and disease and the potential impact on personalized dental medicineQ37929297
Computational systems biology and in silico modeling of the human microbiomeQ38010422
A systems biology approach to studying the role of microbes in human health.Q38055938
Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationshipsQ38578618
Strain- and plasmid-level deconvolution of a synthetic metagenome by sequencing proximity ligation productsQ39177394
Competitive and cooperative metabolic interactions in bacterial communities.Q39676882
Xenobiotics and the human gut microbiome: metatranscriptomics reveal the active playersQ40300533
New approaches for isolation of previously uncultivated oral bacteriaQ40311047
Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolismQ41846171
An ecological network of polysaccharide utilization among human intestinal symbiontsQ41955485
Emergent cooperation in microbial metabolismQ42397954
Topological signatures of species interactions in metabolic networksQ42592490
A de novo metagenomic assembly program for shotgun DNA reads.Q42643842
Strong inter-population cooperation leads to partner intermixing in microbial communitiesQ34566652
Towards a predictive systems-level model of the human microbiome: progress, challenges, and opportunitiesQ34691436
Metaproteomics of our microbiome - developing insight in function and activity in man and model systemsQ34740353
Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic miceQ34794391
Metabolic modeling of species interaction in the human microbiome elucidates community-level assembly rulesQ34822704
Human colonic microbiota associated with diet, obesity and weight lossQ34823807
Comparative metatranscriptomics reveals kingdom level changes in the rhizosphere microbiome of plantsQ34830182
Science and complexity.Q34854677
Stool microbiome and metabolome differences between colorectal cancer patients and healthy adultsQ34936050
Understanding the interactions between bacteria in the human gut through metabolic modelingQ34975280
Genome assembly reborn: recent computational challengesQ34984047
Human gut microbiome adopts an alternative state following small bowel transplantationQ35006562
Synergistic interactions in the microbial worldQ35007709
Reconstructing the genomic content of microbiome taxa through shotgun metagenomic deconvolutionQ35022283
Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiotaQ35069150
Mathematical modeling of primary succession of murine intestinal microbiota.Q35075057
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humansQ35080321
Environmental and gut bacteroidetes: the food connection.Q35084646
Genome-scale microbial in silico models: the constraints-based approach.Q35101082
Thirteen years of building constraint-based in silico models of Escherichia coliQ35109629
Metatranscriptomics of the human oral microbiome during health and diseaseQ35137846
Emergent biosynthetic capacity in simple microbial communitiesQ35200847
Evidence for a core gut microbiota in the zebrafish.Q35222659
Microbiota and SCFA in lean and overweight healthy subjectsQ29615812
A phylogeny-driven genomic encyclopaedia of Bacteria and ArchaeaQ29616591
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiomeQ29617424
The impact of the gut microbiota on human health: an integrative viewQ29617446
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbationQ29617796
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental dataQ29618471
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infectionQ30066419
Evaluation of microbial community reproducibility, stability and composition in a human distal gut chemostat model.Q31135273
Metaproteomics approach to study the functionality of the microbiota in the human infant gastrointestinal tractQ33266094
Simultaneous assessment of soil microbial community structure and function through analysis of the meta-transcriptomeQ33346229
In silico approaches to study mass and energy flows in microbial consortia: a syntrophic case study.Q33517877
Count: evolutionary analysis of phylogenetic profiles with parsimony and likelihoodQ33605558
Graph-based analysis of the metabolic exchanges between two co-resident intracellular symbionts, Baumannia cicadellinicola and Sulcia muelleri, with their insect host, Homalodisca coagulataQ33691388
MetAMOS: a modular and open source metagenomic assembly and analysis pipelineQ33741975
Metagenomic systems biology and metabolic modeling of the human microbiome: from species composition to community assembly rulesQ33779279
Multispecies communities: interspecies interactions influence growth on saliva as sole nutritional sourceQ33870205
Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamicsQ33900751
Ribosomal RNA diversity predicts genome diversity in gut bacteria and their relativesQ33959353
The large-scale organization of the bacterial network of ecological co-occurrence interactions.Q33959392
Species-level deconvolution of metagenome assemblies with Hi-C-based contact probability mapsQ34041056
A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communitiesQ34050854
Untangling genomes from metagenomes: revealing an uncultured class of marine EuryarchaeotaQ34149345
OptCom: a multi-level optimization framework for the metabolic modeling and analysis of microbial communitiesQ34154442
IDBA-UD: a de novo assembler for single-cell and metagenomic sequencing data with highly uneven depthQ34229322
Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel diseaseQ34241773
Generation and analysis of a mouse intestinal metatranscriptome through Illumina based RNA-sequencingQ34257026
Metagenome, metatranscriptome and single-cell sequencing reveal microbial response to Deepwater Horizon oil spillQ34283016
Growing unculturable bacteriaQ34290686
Lymphotoxin regulates commensal responses to enable diet-induced obesityQ34295896
Reverse Ecology: from systems to environments and backQ34347514
The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to CyanobacteriaQ34378530
Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonizationQ34398619
The evolution of mutualism in gut microbiota via host epithelial selectionQ34489494
Temporal expression-based analysis of metabolismQ34499316
Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's diseaseQ34499601
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADREQ34509501
P433issue5
P921main subjectmetagenomicsQ903778
microbiomeQ1330402
P304page(s)742-752
P577publication date2014-08-28
P1433published inCell MetabolismQ1254684
P1476titleMapping the inner workings of the microbiome: genomic- and metagenomic-based study of metabolism and metabolic interactions in the human microbiome
P478volume20

Reverse relations

cites work (P2860)
Q64079560A Conceptual Framework for Studying and Investing in Precision Nutrition
Q90871259An interspecies malate-pyruvate shuttle reconciles redox imbalance in an anaerobic microbial community
Q35595024Anoxic Conditions Promote Species-Specific Mutualism between Gut Microbes In Silico
Q89551473Computational Modeling of the Human Microbiome
Q90474825Contrasting Strategies: Human Eukaryotic Versus Bacterial Microbiome Research
Q89508376Cross-feeding modulates antibiotic tolerance in bacterial communities
Q92058461Defining and Evaluating Microbial Contributions to Metabolite Variation in Microbiome-Metabolome Association Studies
Q91902598Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data
Q34851339Finding and identifying the viral needle in the metagenomic haystack: trends and challenges
Q35861517From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease
Q26800805From cultured to uncultured genome sequences: metagenomics and modeling microbial ecosystems
Q28082185From next-generation sequencing to systematic modeling of the gut microbiome
Q39230899Gut microbiota functions: metabolism of nutrients and other food components
Q38924657High-resolution characterization of the human microbiome
Q28610549Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes
Q35841229Host Genetic Control of the Microbiota Mediates the Drosophila Nutritional Phenotype
Q93351736Lung inflammation and disease: A perspective on microbial homeostasis and metabolism
Q35764339MICROBIOME. Microbial growth dynamics and human disease
Q30279122Metabolic network modeling of microbial communities
Q28817713Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior
Q28270292Metagenome Analysis Exploiting High-Throughput Chromosome Conformation Capture (3C) Data
Q26747593Metagenomics, Metatranscriptomics, and Metabolomics Approaches for Microbiome Analysis
Q36209337Panamanian frog species host unique skin bacterial communities
Q38792983Predicting microbial interactions through computational approaches
Q47098492Q&A: Friends (but sometimes foes) within: the complex evolutionary ecology of symbioses between host and microbes
Q46251995Resources and tools for the high-throughput, multi-omic study of intestinal microbiota
Q41521034Self-establishing communities enable cooperative metabolite exchange in a eukaryote
Q98177377Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative Diseases
Q35186525The demographic determinants of human microbiome health
Q37334916Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model
Q26766432Using "Omics" and Integrated Multi-Omics Approaches to Guide Probiotic Selection to Mitigate Chytridiomycosis and Other Emerging Infectious Diseases
Q34988909Where next for microbiome research?

Search more.