Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer

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Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2363
P932PMC publication ID4253425
P698PubMed publication ID25193856
P5875ResearchGate publication ID265418933

P2093author name stringSoon-Sun Hong
Mi-Hyun Kim
Juyoung Kim
Kyung Hee Jung
Soo Jung Kim
Hong Hua Yan
Mi Kwon Son
Zhenghuan Fang
Ye-Lim Ryu
P2860cites workCancer statistics, 2014Q27861018
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indicationsQ28506804
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancerQ29547638
Pancreatic cancerQ29616288
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials GroupQ29619344
An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasisQ33588267
Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancerQ33868282
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomasQ34037769
Developing c-MET pathway inhibitors for cancer therapy: progress and challengesQ34089725
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanismsQ34625881
Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinomaQ35004346
Does more accurate exposure prediction necessarily improve health effect estimates?Q35370777
Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged nonsmall cell lung cancer and beyondQ35596686
The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancerQ36907124
The anaplastic lymphoma kinase in the pathogenesis of cancerQ37039605
Inhibition of ALK signaling for cancer therapyQ37593792
Anaplastic Lymphoma Kinase: Role in specific tumours, and development of small molecule inhibitors for cancer therapyQ37799137
Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinasesQ37820500
Targeting Oncogenic ALK: A Promising Strategy for Cancer TreatmentQ37862882
c-MET as a potential therapeutic target and biomarker in cancerQ37962905
Anaplastic lymphoma kinase as a therapeutic target.Q38045455
Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibitionQ38064218
New molecular targets in the treatment of NSCLC.Q38080101
Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancerQ39166185
HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesisQ39289182
Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET AmplificationQ39325851
c-Met in pancreatic cancer stem cells: therapeutic implications.Q42426376
MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET AlterationsQ42731321
SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activitiesQ43559869
Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer.Q43800126
Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancerQ45106840
Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancerQ46602989
Expression and Prognostic Significance of CD151, c-Met, and Integrin alpha3/alpha6 in Pancreatic Ductal AdenocarcinomaQ54645357
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancerQ72571222
c-Met is a marker of pancreatic cancer stem cells and therapeutic targetQ84816959
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
crizotinibQ5186964
P304page(s)9150-9168
P577publication date2014-10-01
P1433published inOncotargetQ1573155
P1476titleCrizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer
P478volume5

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cites work (P2860)
Q52902964Clinical Advanced in Early-stage ALK-positive Non-small Cell Lung Cancer Patients
Q92133931Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer
Q36020888Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling
Q58574781HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers
Q36759077Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment
Q26787087Novel agents for advanced pancreatic cancer
Q37624480Pancreatic stellate cell: Pandora's box for pancreatic disease biology
Q90620375Promising new treatments for pancreatic cancer in the era of targeted and immune therapies
Q28081193Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets

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