crizotinib

chemical compound

Wikidata entity: Q5186964

C₂₁H₂₂Cl₂FN₅O (P274)


Wikimedia Commons category is Crizotinib

Quantities

P2067mass449.119

P3780 active ingredient in ... Q29006680 (Xalkori) Xalkori
P233 canonical SMILES String CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N ???
P373 Commons category String Crizotinib ???
P366 has use ... Q12140 (medication) medication
P31 instance of ... Q113145171 (type of chemical entity) type of chemical entity
P2017 isomeric SMILES String C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N ???
P8026 LiverTox likelihood score ... Q83284310 (LiverTox toxicity likelihood category C) LiverTox toxicity likelihood category C
P2175 medical condition treated ... Q55998694 (neuroblastoma, susceptibility to) neuroblastoma, susceptibility to
P2175 medical condition treated ... Q3658562 (non-small-cell lung carcinoma) non-small-cell lung carcinoma
P2175 medical condition treated ... Q6030100 (inflammatory myofibroblastic tumour) inflammatory myofibroblastic tumour
P2175 medical condition treated ... Q18556109 (bronchus carcinoma) bronchus carcinoma
P129 physically interacts with ... Q5005897 (MET proto-oncogene, receptor tyrosine kinase) MET proto-oncogene, receptor tyrosine kinase
P129 physically interacts with ... Q21111336 (ALK receptor tyrosine kinase) ALK receptor tyrosine kinase
P3489 pregnancy category ... Q3679274 (Australian pregnancy category D) Australian pregnancy category D
P3489 pregnancy category ... Q28123618 (US pregnancy category D) US pregnancy category D
P769 significant drug interaction ... Q118551 (clarithromycin) clarithromycin
P769 significant drug interaction ... Q144085 (pimozide) pimozide
P769 significant drug interaction ... Q174259 (droperidol) droperidol
P769 significant drug interaction ... Q189522 (quinine) quinine
P769 significant drug interaction ... Q176533 (alfentanil) alfentanil
P769 significant drug interaction ... Q179996 ((RS)-methadone) (RS)-methadone
P769 significant drug interaction ... Q410061 (amiodarone) amiodarone
P769 significant drug interaction ... Q410291 (verapamil) verapamil
P769 significant drug interaction ... Q411229 (itraconazole) itraconazole
P769 significant drug interaction ... Q213511 (erythromycin) erythromycin
P769 significant drug interaction ... Q228143 (zuclopenthixol) zuclopenthixol
P769 significant drug interaction ... Q251347 (haloperidol) haloperidol
P769 significant drug interaction ... Q7739 (arsenic trioxide) arsenic trioxide
P769 significant drug interaction ... Q407883 (ketoconazole) ketoconazole
P769 significant drug interaction ... Q407972 (chlorpromazine) chlorpromazine
P769 significant drug interaction ... Q422229 (diltiazem) diltiazem
P769 significant drug interaction ... Q422418 ((RS)-sulpiride) (RS)-sulpiride
P769 significant drug interaction ... Q421136 (sorafenib) sorafenib
P769 significant drug interaction ... Q421937 ((RS)-hydroxyzine) (RS)-hydroxyzine
P769 significant drug interaction ... Q422222 (digoxin) digoxin
P769 significant drug interaction ... Q411325 (atenolol) atenolol
P769 significant drug interaction ... Q411648 (tacrolimus) tacrolimus
P769 significant drug interaction ... Q408163 (anagrelide) anagrelide
P769 significant drug interaction ... Q408535 (quetiapine) quetiapine
P769 significant drug interaction ... Q422618 (ritonavir) ritonavir
P769 significant drug interaction ... Q423364 (propranolol) propranolol
P769 significant drug interaction ... Q423762 (paclitaxel) paclitaxel
P769 significant drug interaction ... Q424238 (domperidone) domperidone
P769 significant drug interaction ... Q424940 (moxifloxacin) moxifloxacin
P769 significant drug interaction ... Q412221 (clonidine) clonidine
P769 significant drug interaction ... Q412236 (voriconazole) voriconazole
P769 significant drug interaction ... Q412327 (nilotinib) nilotinib
P769 significant drug interaction ... Q419186 (ergotamine) ergotamine
P769 significant drug interaction ... Q420323 (lapatinib) lapatinib
P769 significant drug interaction ... Q420586 (celiprolol) celiprolol
P769 significant drug interaction ... Q412515 (bisoprolol) bisoprolol
P769 significant drug interaction ... Q412534 (carvedilol) carvedilol
P769 significant drug interaction ... Q424952 (nadolol) nadolol
P769 significant drug interaction ... Q425120 (disopyramide) disopyramide
P769 significant drug interaction ... Q425137 (fingolimod) fingolimod
P769 significant drug interaction ... Q3896970 (pasireotide) pasireotide
P769 significant drug interaction ... Q3993743 ((Z)-Toremifene) (Z)-Toremifene
P769 significant drug interaction ... Q5473363 (fosphenytoin) fosphenytoin
P769 significant drug interaction ... Q5908266 (idelalisib) idelalisib
P769 significant drug interaction ... Q5984881 (ibrutinib) ibrutinib
P769 significant drug interaction ... Q408556 (levobunolol) levobunolol
P769 significant drug interaction ... Q408637 (dronedarone) dronedarone
P769 significant drug interaction ... Q409468 ((RS)-metoprolol) (RS)-metoprolol
P769 significant drug interaction ... Q27139135 (dasatinib monohydrate) dasatinib monohydrate
P769 significant drug interaction ... Q425729 (ivabradine) ivabradine
P769 significant drug interaction ... Q736270 (mefloquine) mefloquine
P769 significant drug interaction ... Q794162 (betaxolol) betaxolol
P769 significant drug interaction ... Q409672 ((RS)-citalopram) (RS)-citalopram
P769 significant drug interaction ... Q410011 (ondansetron) ondansetron
P769 significant drug interaction ... Q894611 (bosutinib) bosutinib
P769 significant drug interaction ... Q958087 (labetalol) labetalol
P769 significant drug interaction ... Q3011604 (dabrafenib) dabrafenib
P769 significant drug interaction ... Q412690 (galantamine) galantamine
P769 significant drug interaction ... Q413591 (sotalol) sotalol
P769 significant drug interaction ... Q415081 (donepezil) donepezil
P769 significant drug interaction ... Q7157043 (pazopanib) pazopanib
P769 significant drug interaction ... Q7914515 (vandetanib) vandetanib
P769 significant drug interaction ... Q21011233 (ceritinib) ceritinib
P769 significant drug interaction ... Q416206 (pentamidine) pentamidine
P769 significant drug interaction ... Q417542 (sunitinib) sunitinib
P769 significant drug interaction ... Q417915 (sufentanil) sufentanil
P769 significant drug interaction ... Q418101 (pindolol) pindolol
P769 significant drug interaction ... Q418130 (nebivolol) nebivolol
P769 significant drug interaction ... Q418139 (esmolol) esmolol
P769 significant drug interaction ... Q418857 (acebutolol) acebutolol
P3364 stereoisomer of ... Q27467066 (3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine) 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
P279 subclass of ... Q82296813 (critozinib (unspec. stereochem.)) critozinib (unspec. stereochem.)
P2868 subject has role ... Q50348938 (xenobiotic-transporting ATPase inhibitor) xenobiotic-transporting ATPase inhibitor
P2868 subject has role ... Q7251487 (protein kinase inhibitors) protein kinase inhibitors
P2275 World Health Organisation international non-proprietary name Monolingualtext crizotinib ???
External Ids
P267ATC codeL01XE16
P231CAS Registry Number877399-52-5
P683ChEBI ID64310
P592ChEMBL IDCHEMBL601719
P661ChemSpider ID9801307
P715DrugBank IDDB08865
P11198DrugCentral ID4187
P8494DSSTOX compound identifierDTXCID601436157
P3117DSSTox substance IDDTXSID701009329
P232EC number638-814-9
P2566ECHA Substance Infocard ID100.166.440
P9635electronic Essential Medicines List medicine ID585
P646Freebase ID/m/0c418c1
P595Guide to Pharmacology Ligand ID4903
P234InChIInChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
P235InChIKeyKTEIFNKAUNYNJU-GFCCVEGCSA-N
P665KEGG IDD09731
P7830LiverTox IDCrizotinib
P10245MedlinePlus drug identifiera612018
P486MeSH descriptor IDD000077547
P672MeSH tree codeD03.383.621.154
P672MeSH tree codeD03.383.725.050.263
P6366Microsoft Academic ID (discontinued)2779422266
P2115NDF-RT IDN0000183253
P2840NSC number756645
P10283OpenAlex IDC2779422266
P4235PatientsLikeMe treatment IDcrizotinib
P3636PDB ligand IDVGH
P638PDB structure ID4C9W
P638PDB structure ID4ANQ
P638PDB structure ID3ZBF
P638PDB structure ID5AAC
P638PDB structure ID5AAA
P638PDB structure ID2XP2
P638PDB structure ID4ANS
P638PDB structure ID2YFX
P638PDB structure ID5AAB
P638PDB structure ID2WGJ
P11199Probes And Drugs IDPD003326
P662PubChem CID11626560
P1579Reaxys registry number12133926
P3345RxNorm CUI1148495
P4964SPLASHsplash10-0udi-1693800000-fc52c38f3359a378554a
P2877SureChEMBL ID93829
P2892UMLS CUIC2974289
P11089UniChem compound ID53865
P652UNII53AH36668S
P11143WikiProjectMed IDCrizotinib

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