sorafenib

chemical compound

Wikidata entity: Q421136

C₂₁H₁₆ClF₃N₄O₃ (P274)


Wikimedia Commons category is Sorafenib



Quantities

P2067mass464.086

P3780 active ingredient in ... Q29006218 (Nexavar) Nexavar
P233 canonical SMILES String CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F ???
P373 Commons category String Sorafenib ???
P703 found in taxon ... Q948827 (Asimina triloba) Asimina triloba
P703 found in taxon ... Q2066891 (Phoma) Phoma
P703 found in taxon ... Q3706791 (Diaporthe) Diaporthe
P703 found in taxon ... Q54366202 (Curvularia lunata) Curvularia lunata
P703 found in taxon ... Q4807897 (Aspergillus ochraceus) Aspergillus ochraceus
P527 has part(s) ... Q650 (fluorine) fluorine
P527 has part(s) ... Q623 (carbon) carbon
P527 has part(s) ... Q627 (nitrogen) nitrogen
P527 has part(s) ... Q688 (chlorine) chlorine
P366 has use ... Q12140 (medication) medication
P31 instance of ... Q113145171 (type of chemical entity) type of chemical entity
P8026 LiverTox likelihood score ... Q83284157 (LiverTox toxicity likelihood category B) LiverTox toxicity likelihood category B
P2175 medical condition treated ... Q1148337 (hepatocellular carcinoma) hepatocellular carcinoma
P2175 medical condition treated ... Q1164529 (renal cell carcinoma) renal cell carcinoma
P2175 medical condition treated ... Q3242950 (kidney cancer) kidney cancer
P2175 medical condition treated ... Q18556131 (thyroid carcinoma) thyroid carcinoma
P2175 medical condition treated ... Q55998489 (thyroid cancer, nonmedullary, 1) thyroid cancer, nonmedullary, 1
P2175 medical condition treated ... Q264118 (acute myeloid leukemia) acute myeloid leukemia
P129 physically interacts with ... Q410434 (Raf-1 proto-oncogene, serine/threonine kinase) Raf-1 proto-oncogene, serine/threonine kinase
P129 physically interacts with ... Q415976 (ret proto-oncogene) ret proto-oncogene
P129 physically interacts with ... Q909409 (KIT proto-oncogene, receptor tyrosine kinase) KIT proto-oncogene, receptor tyrosine kinase
P129 physically interacts with ... Q21109218 (B-Raf proto-oncogene, serine/threonine kinase) B-Raf proto-oncogene, serine/threonine kinase
P129 physically interacts with ... Q21156191 (Cyclin dependent kinase 19) Cyclin dependent kinase 19
P129 physically interacts with ... Q21172390 (kinase insert domain receptor) kinase insert domain receptor
P129 physically interacts with ... Q21983261 (Platelet derived growth factor receptor, beta polypeptide) Platelet derived growth factor receptor, beta polypeptide
P129 physically interacts with ... Q21992684 (FMS-like tyrosine kinase 4) FMS-like tyrosine kinase 4
P129 physically interacts with ... Q4036865 (Discoidin domain receptor tyrosine kinase 2) Discoidin domain receptor tyrosine kinase 2
P129 physically interacts with ... Q5009781 (fms related receptor tyrosine kinase 3) fms related receptor tyrosine kinase 3
P129 physically interacts with ... Q5198254 (Cyclin dependent kinase 8) Cyclin dependent kinase 8
P129 physically interacts with ... Q5446453 (fibroblast growth factor receptor 1) fibroblast growth factor receptor 1
P3489 pregnancy category ... Q3679274 (Australian pregnancy category D) Australian pregnancy category D
P3489 pregnancy category ... Q28123618 (US pregnancy category D) US pregnancy category D
P769 significant drug interaction ... Q412236 (voriconazole) voriconazole
P769 significant drug interaction ... Q118551 (clarithromycin) clarithromycin
P769 significant drug interaction ... Q213511 (erythromycin) erythromycin
P769 significant drug interaction ... Q5186964 (crizotinib) crizotinib
P769 significant drug interaction ... Q5908266 (idelalisib) idelalisib
P9989 stylized name String NexAVAR ???
P9989 stylized name String SORAfenib ???
P279 subclass of ... Q11173 (chemical compound) chemical compound
P2868 subject has role ... Q2853144 (antineoplastic) antineoplastic
P2868 subject has role ... Q7251487 (protein kinase inhibitors) protein kinase inhibitors

External Ids
P267ATC codeL01XE05
P8072CAB ID28911
P231CAS Registry Number284461-73-0
P6852CCDC Number813502
P683ChEBI ID50924
P592ChEMBL IDCHEMBL1336
P661ChemSpider ID187440
P11375CSD RefcodeAKENOU
P9272DeCS ID57527
P715DrugBank IDDB00398
P11198DrugCentral ID2459
P8494DSSTOX compound identifierDTXCID5021128
P3117DSSTox substance IDDTXSID7041128
P232EC number608-209-4
P2566ECHA Substance Infocard ID100.110.083
P646Freebase ID/m/09gh4q
P595Guide to Pharmacology Ligand ID5711
P2062HSDB ID8173
P2057Human Metabolome Database IDHMDB0014542
P234InChIInChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
P235InChIKeyMLDQJTXFUGDVEO-UHFFFAOYSA-N
P665KEGG IDD08524
P7830LiverTox IDSorafenib
P10245MedlinePlus drug identifiera607051
P486MeSH descriptor IDD000077157
P672MeSH tree codeD02.065.950.681.757
P672MeSH tree codeD02.455.426.559.389.703.757
P672MeSH tree codeD03.066.515.530.750
P672MeSH tree codeD03.383.725.547.530.750
P6366Microsoft Academic ID (discontinued)2778695046
P2115NDF-RT IDN0000171742
P10283OpenAlex IDC2778695046
P3636PDB ligand IDBAX
P638PDB structure ID3RGF
P638PDB structure ID3HEG
P638PDB structure ID1UWH
P638PDB structure ID1UWJ
P638PDB structure ID5HI2
P638PDB structure ID3GCS
P638PDB structure ID4ASD
P638PDB structure ID3WZE
P11199Probes And Drugs IDPD003493
P662PubChem CID216239
P3345RxNorm CUI495881
P2877SureChEMBL ID8218
P2892UMLS CUIC1174389
P2892UMLS CUIC1516119
P11089UniChem compound ID235132
P652UNII9ZOQ3TZI87
P11143WikiProjectMed IDSorafenib

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