Raf-1 proto-oncogene, serine/threonine kinase

mammalian protein found in Homo sapiens

Wikidata entity: Q410434



P682 biological process ... Q189101 (cell population proliferation) cell population proliferation
P682 biological process ... Q210861 (cell differentiation) cell differentiation
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q1509074 (wound healing) wound healing
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q471817 (development of the heart) development of the heart
P682 biological process ... Q828130 (signal transduction) signal transduction
P682 biological process ... Q14599311 (apoptotic process) apoptotic process
P682 biological process ... Q14599399 (negative regulation of cell population proliferation) negative regulation of cell population proliferation
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14599551 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
P682 biological process ... Q14633911 (regulation of apoptotic process) regulation of apoptotic process
P682 biological process ... Q14645705 (multicellular organism development) multicellular organism development
P682 biological process ... Q14758900 (MAPK cascade) MAPK cascade
P682 biological process ... Q14818068 (positive regulation of transcription by RNA polymerase II) positive regulation of transcription by RNA polymerase II
P682 biological process ... Q14819239 (response to hypoxia) response to hypoxia
P682 biological process ... Q21095173 (stimulatory C-type lectin receptor signaling pathway) stimulatory C-type lectin receptor signaling pathway
P682 biological process ... Q21095369 (response to muscle stretch) response to muscle stretch
P682 biological process ... Q21108800 (insulin secretion involved in cellular response to glucose stimulus) insulin secretion involved in cellular response to glucose stimulus
P682 biological process ... Q14819467 (platelet activation) platelet activation
P682 biological process ... Q14819846 (positive regulation of protein phosphorylation) positive regulation of protein phosphorylation
P682 biological process ... Q14820663 (positive regulation of peptidyl-serine phosphorylation) positive regulation of peptidyl-serine phosphorylation
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14851952 (intracellular signal transduction) intracellular signal transduction
P682 biological process ... Q14859939 (thyroid gland development) thyroid gland development
P682 biological process ... Q14859964 (thymus development) thymus development
P682 biological process ... Q14860503 (activation of adenylate cyclase activity) activation of adenylate cyclase activity
P682 biological process ... Q14862215 (regulation of cell motility) regulation of cell motility
P682 biological process ... Q14863062 (cellular glucose homeostasis) cellular glucose homeostasis
P682 biological process ... Q14864161 (intermediate filament cytoskeleton organization) intermediate filament cytoskeleton organization
P682 biological process ... Q14864652 (somatic stem cell population maintenance) somatic stem cell population maintenance
P682 biological process ... Q14864688 (neurotrophin TRK receptor signaling pathway) neurotrophin TRK receptor signaling pathway
P682 biological process ... Q14865154 (ion transmembrane transport) ion transmembrane transport
P682 biological process ... Q14874552 (regulation of cell differentiation) regulation of cell differentiation
P682 biological process ... Q14882920 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
P682 biological process ... Q14887292 (negative regulation of protein-containing complex assembly) negative regulation of protein-containing complex assembly
P682 biological process ... Q14903572 (regulation of Rho protein signal transduction) regulation of Rho protein signal transduction
P682 biological process ... Q14903575 (death-inducing signaling complex assembly) death-inducing signaling complex assembly
P682 biological process ... Q14905137 (negative regulation of signal transduction) negative regulation of signal transduction
P682 biological process ... Q14912098 (face development) face development
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q39572 (mitochondrion) mitochondrion
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q165291 (pseudopodium) pseudopodium
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q14330611 (mitochondrial outer membrane) mitochondrial outer membrane
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14819271 (nuclear speck) nuclear speck
P702 encoded by ... Q14903573 (RAF1) RAF1
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20RAF1%20201244%20s%20at%20fs.png ???
P527 has part(s) ... Q24721120 (diacylglycerol/phorbol-ester binding) diacylglycerol/phorbol-ester binding
P527 has part(s) ... Q24724299 (protein kinase C-like, phorbol ester/diacylglycerol-binding domain) protein kinase C-like, phorbol ester/diacylglycerol-binding domain
P527 has part(s) ... Q24740842 (serine-threonine/tyrosine-protein kinase, catalytic domain) serine-threonine/tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24741309 (Raf-like Ras-binding) Raf-like Ras-binding
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24787419 (serine/threonine-protein kinase, active site) serine/threonine-protein kinase, active site
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q14326094 (protein serine/threonine kinase activity) protein serine/threonine kinase activity
P680 molecular function ... Q14599289 (enzyme binding) enzyme binding
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P680 molecular function ... Q14762999 (protein heterodimerization activity) protein heterodimerization activity
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14865542 (MAP kinase kinase kinase activity) MAP kinase kinase kinase activity
P680 molecular function ... Q14903565 (mitogen-activated protein kinase kinase binding) mitogen-activated protein kinase kinase binding
P680 molecular function ... Q14916374 (adenylate cyclase binding) adenylate cyclase binding
P680 molecular function ... Q15311765 (small GTPase binding) small GTPase binding
P680 molecular function ... Q22314138 (adenylate cyclase activator activity) adenylate cyclase activator activity
P361 part of ... Q24725964 (Ubiquitin-like domain superfamily) Ubiquitin-like domain superfamily
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q83132853 (Diacylglycerol/phorbol-ester binding domain, protein family) Diacylglycerol/phorbol-ester binding domain, protein family
P361 part of ... Q83134938 (Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family) Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family
P361 part of ... Q83137014 (Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family) Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83137224 (Raf-like Ras-binding domain, protein family) Raf-like Ras-binding domain, protein family
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q95353644 (Serine/threonine-protein kinase, active site, protein family) Serine/threonine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P129 physically interacts with ... Q421136 (sorafenib) sorafenib
P129 physically interacts with ... Q423111 (vemurafenib) vemurafenib

External Ids
P705Ensembl protein IDENSP00000398591
P705Ensembl protein IDENSP00000401088
P705Ensembl protein IDENSP00000251849
P705Ensembl protein IDENSP00000401888
P705Ensembl protein IDENSP00000391265
P646Freebase ID/m/0dwyv2
P486MeSH descriptor IDD019908
P672MeSH tree codeD08.811.913.696.620.682.700.559.842.500
P672MeSH tree codeD12.776.476.563.554.842.500
P672MeSH tree codeD12.776.624.664.700.204.500
P6366Microsoft Academic ID (discontinued)99405784
P10283OpenAlex IDC99405784
P638PDB structure ID3CU8
P638PDB structure ID3O8I
P638PDB structure ID4IHL
P638PDB structure ID3NKX
P638PDB structure ID4G0N
P638PDB structure ID3OMV
P638PDB structure ID4FJ3
P638PDB structure ID1C1Y
P638PDB structure ID1GUA
P638PDB structure ID3KUC
P638PDB structure ID3IQJ
P638PDB structure ID3IQU
P638PDB structure ID3IQV
P638PDB structure ID4IEA
P638PDB structure ID1FAQ
P638PDB structure ID1FAR
P638PDB structure ID1RFA
P638PDB structure ID3KUD
P638PDB structure ID4G3X
P637RefSeq protein IDNP_001341618
P637RefSeq protein IDNP_001341619
P637RefSeq protein IDNP_001341620
P637RefSeq protein IDNP_001341621
P637RefSeq protein IDNP_001341622
P637RefSeq protein IDNP_001341623
P637RefSeq protein IDNP_001341624
P637RefSeq protein IDNP_002871
P637RefSeq protein IDXP_011532276
P637RefSeq protein IDXP_016862455
P2892UMLS CUIC0139030
P352UniProt protein IDP04049

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