tacrolimus

Immunosuppressive Rx drug

Wikidata entity: Q411648

C₄₄H₆₉NO₁₂ (P274)


Wikimedia Commons category is Tacrolimus

Quantities

P4250defined daily dose5
P2067mass803.482

P233 canonical SMILES String CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC ???
P373 Commons category String Tacrolimus ???
P703 found in taxon ... Q843136 (Penicillium) Penicillium
P703 found in taxon ... Q3975996 (Streptomyces hygroscopicus) Streptomyces hygroscopicus
P703 found in taxon ... Q7623381 (Streptomyces clavuligerus) Streptomyces clavuligerus
P703 found in taxon ... Q24915252 (Streptomyces tacrolimicus) Streptomyces tacrolimicus
P366 has use ... Q12140 (medication) medication
P366 has use ... Q25326509 (chemical probe) chemical probe
P31 instance of ... Q113145171 (type of chemical entity) type of chemical entity
P2017 isomeric SMILES String C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC ???
P3493 legal status (medicine) ... Q879952 (boxed warning) boxed warning
P176 manufacturer ... Q206921 (Pfizer) Pfizer
P2175 medical condition treated ... Q1477 (ulcerative colitis) ulcerative colitis
P2175 medical condition treated ... Q8285 (myasthenia gravis) myasthenia gravis
P2175 medical condition treated ... Q180152 (vitiligo) vitiligo
P2175 medical condition treated ... Q167844 (conjunctivitis) conjunctivitis
P2175 medical condition treated ... Q268667 (atopic dermatitis) atopic dermatitis
P2175 medical condition treated ... Q1153419 (interstitial lung disease) interstitial lung disease
P2175 medical condition treated ... Q1194520 (graft-versus-host disease) graft-versus-host disease
P2175 medical condition treated ... Q980926 (polymyositis) polymyositis
P2175 medical condition treated ... Q848371 (lichen planus) lichen planus
P2175 medical condition treated ... Q1621830 (lupus nephritis) lupus nephritis
P2175 medical condition treated ... Q504790 (nephrotic syndrome) nephrotic syndrome
P2175 medical condition treated ... Q56014460 (acute graft versus host disease) acute graft versus host disease
P2175 medical condition treated ... Q786844 (autoimmune hepatitis) autoimmune hepatitis
P680 molecular function ... Q14907971 (FK506 binding) FK506 binding
P361 part of ... Q14907971 (FK506 binding) FK506 binding
P129 physically interacts with ... Q21110396 (FKBP prolyl isomerase 1A) FKBP prolyl isomerase 1A
P3489 pregnancy category ... Q3679261 (Australian pregnancy category C) Australian pregnancy category C
P3489 pregnancy category ... Q28123617 (US pregnancy category C) US pregnancy category C
P636 route of administration ... Q285166 (oral administration) oral administration
P636 route of administration ... Q640448 (intravenous infusion and defusion) intravenous infusion and defusion
P769 significant drug interaction ... Q45050 (tenoxicam) tenoxicam
P769 significant drug interaction ... Q118551 (clarithromycin) clarithromycin
P769 significant drug interaction ... Q186969 (ibuprofen) ibuprofen
P769 significant drug interaction ... Q213511 (erythromycin) erythromycin
P769 significant drug interaction ... Q244408 (Diclofenac) Diclofenac
P769 significant drug interaction ... Q408637 (dronedarone) dronedarone
P769 significant drug interaction ... Q408676 (piroxicam) piroxicam
P769 significant drug interaction ... Q408801 (celecoxib) celecoxib
P769 significant drug interaction ... Q409192 ((RS)-ketoprofen) (RS)-ketoprofen
P769 significant drug interaction ... Q409231 (indomethacin) indomethacin
P769 significant drug interaction ... Q347941 (parecoxib) parecoxib
P769 significant drug interaction ... Q367700 (cyclosporine) cyclosporine
P769 significant drug interaction ... Q407883 (ketoconazole) ketoconazole
P769 significant drug interaction ... Q410061 (amiodarone) amiodarone
P769 significant drug interaction ... Q411229 (itraconazole) itraconazole
P769 significant drug interaction ... Q416206 (pentamidine) pentamidine
P769 significant drug interaction ... Q417640 (ganciclovir) ganciclovir
P769 significant drug interaction ... Q419890 ((±)-flurbiprofen) (±)-flurbiprofen
P769 significant drug interaction ... Q420387 (foscarnet) foscarnet
P769 significant drug interaction ... Q422618 (ritonavir) ritonavir
P769 significant drug interaction ... Q422654 (saquinavir) saquinavir
P769 significant drug interaction ... Q423384 (valganciclovir) valganciclovir
P769 significant drug interaction ... Q411478 (fluconazole) fluconazole
P769 significant drug interaction ... Q412236 (voriconazole) voriconazole
P769 significant drug interaction ... Q414028 (meloxicam) meloxicam
P769 significant drug interaction ... Q1215575 (naproxen) naproxen
P769 significant drug interaction ... Q907104 (ranolazine) ranolazine
P769 significant drug interaction ... Q963093 (sulindac) sulindac
P769 significant drug interaction ... Q423467 (atazanavir) atazanavir
P769 significant drug interaction ... Q425207 (nabumetone) nabumetone
P769 significant drug interaction ... Q5186964 (crizotinib) crizotinib
P769 significant drug interaction ... Q5473363 (fosphenytoin) fosphenytoin
P769 significant drug interaction ... Q2465218 ((RS)-etodolac) (RS)-etodolac
P769 significant drug interaction ... Q2555245 ((RS)-fenoprofen) (RS)-fenoprofen
P769 significant drug interaction ... Q481757 (aceclofenac) aceclofenac
P3364 stereoisomer of ... Q27164938 (LSM-3557) LSM-3557
P3364 stereoisomer of ... Q27166498 (LSM-5735) LSM-5735
P3364 stereoisomer of ... Q63398962 (???) ???
P3364 stereoisomer of ... Q108730784 (???) ???
P279 subclass of ... Q70702 (alkaloid) alkaloid
P279 subclass of ... Q422687 (macrolides) macrolides
P2868 subject has role ... Q249619 (immunosuppressive drug) immunosuppressive drug
P2868 subject has role ... Q427492 (enzyme inhibitor) enzyme inhibitor
P2275 World Health Organisation international non-proprietary name Monolingualtext tacrolimus ???
P2275 World Health Organisation international non-proprietary name Monolingualtext تاكروليموس ???
P2275 World Health Organisation international non-proprietary name Monolingualtext tacrólimus ???
P2275 World Health Organisation international non-proprietary name Monolingualtext tacrolimus ???
P2275 World Health Organisation international non-proprietary name Monolingualtext tacrolimusum ???
P2275 World Health Organisation international non-proprietary name Monolingualtext такролимус ???
P2275 World Health Organisation international non-proprietary name Monolingualtext 他克莫司 ???
External Ids
P267ATC codeD11AH01
P267ATC codeL04AD02
P231CAS Registry Number104987-11-3
P683ChEBI ID61049
P592ChEMBL IDCHEMBL269732
P661ChemSpider ID393220
P715DrugBank IDDB00864
P8494DSSTOX compound identifierDTXCID3026354
P3117DSSTox substance IDDTXSID5046354
P232EC number627-021-3
P2566ECHA Substance Infocard ID100.155.367
P8669Encyclopaedia Beliana IDtacrolimus
P1417Encyclopædia Britannica Online IDtopic/tacrolimus
P646Freebase ID/m/014_0n
P595Guide to Pharmacology Ligand ID6784
P2062HSDB ID8195
P234InChIInChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
P235InChIKeyQJJXYPPXXYFBGM-LFZNUXCKSA-N
P8408KBpedia IDTacrolimus
P665KEGG IDD08556
P665KEGG IDC01375
P244Library of Congress authority IDsh94005977
P2063LIPID MAPS IDLMPK04000003
P10245MedlinePlus drug identifiera601117
P10245MedlinePlus drug identifiera602020
P10245MedlinePlus drug identifiera608037
P6694MeSH concept IDM0329463
P486MeSH descriptor IDD016559
P672MeSH tree codeD02.540.505.810
P2004NALT ID131695
P8189National Library of Israel J9U ID987007549156305171
P2115NDF-RT IDN0000148372
P10283OpenAlex IDC2909675724
P4235PatientsLikeMe treatment IDtacrolimus
P3636PDB ligand IDFK5
P638PDB structure ID1BKF
P638PDB structure ID1FKJ
P638PDB structure ID3UQB
P638PDB structure ID4NNR
P638PDB structure ID4DZ3
P638PDB structure ID5HW8
P638PDB structure ID1Q6I
P638PDB structure ID3VAW
P638PDB structure ID3IHZ
P638PDB structure ID3UQA
P638PDB structure ID4LAX
P638PDB structure ID5B8I
P638PDB structure ID4ODO
P638PDB structure ID5HWC
P638PDB structure ID5D75
P638PDB structure ID1FKF
P638PDB structure ID1TCO
P638PDB structure ID2FKE
P638PDB structure ID3UF8
P638PDB structure ID3O5R
P638PDB structure ID2VN1
P638PDB structure ID5HUA
P638PDB structure ID4DZ2
P638PDB structure ID4ODR
P638PDB structure ID1YAT
P11199Probes And Drugs IDPD003361
P662PubChem CID445643
P1579Reaxys registry number3647477
P1579Reaxys registry number8821611
P3345RxNorm CUI42316
P3345RxNorm CUI235991
P5082Store medisinske leksikon IDtakrolimus
P2877SureChEMBL ID3088
P2892UMLS CUIC0085149
P11089UniChem compound ID184250
P652UNIIY5L2157C4J
P11143WikiProjectMed IDTacrolimus
P2347YSO ID23272

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