Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy

scientific article

Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.00393.2014
P932PMC publication ID4255012
P698PubMed publication ID25260617

P2093author name stringBrenda Russell
Jieli Li
Elaine J Tanhehco
P2860cites workDynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositidesQ36237502
The role of electrostatics in protein-membrane interactionsQ36575065
Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitizationQ36604354
CapZ and actin capping dynamics increase in myocytes after a bout of exercise and abates in hours after stimulation endsQ36924191
Phosphorylation keeps PTEN phosphatase closed for businessQ37083611
The dynamic Z bands of striated muscle cellsQ37242279
Phosphatidylinositol 4,5-bisphosphate regulates CapZβ1 and actin dynamics in response to mechanical strainQ37440245
Phosphoinositide kinases play key roles in norepinephrine- and angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac functionQ37622624
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathwaysQ39750571
PTEN is destabilized by phosphorylation on Thr366.Q40143795
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3betaQ40384036
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosisQ44610984
Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscleQ46505843
Reorganization of the actin cytoskeleton upon G-protein coupled receptor signaling.Q51768461
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stressQ57184516
Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphateQ59072772
Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactinQ59080539
The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survivalQ64379671
Inhibition of fibroblast proliferation in cardiac myocyte cultures by surface microtopographyQ73208529
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulationQ77452079
Phosphorylation of the PTEN tail regulates protein stability and functionQ22254305
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradationQ24290417
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAsQ24315942
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cellsQ24602665
Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptinQ24683598
PTEN and myotubularin: novel phosphoinositide phosphatasesQ27937321
Actin capping protein: an essential element in protein kinase signaling to the myofilamentsQ28207740
Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesionsQ28214350
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxisQ28242514
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heartQ28583542
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension developmentQ30164536
CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms.Q30436192
Regulation of PTEN by Rho small GTPasesQ34406790
PTEN: The down side of PI 3-kinase signalling.Q34540849
Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM proteinQ34564996
Microscope-based techniques to study cell adhesion and migration.Q34594627
Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse modelQ35067637
Physiological functions of Pten in mouse tissuesQ35091345
Membrane-binding and activation mechanism of PTEN.Q35145882
P4510describes a project that usesImageJQ1659584
P433issue11
P304page(s)H1618-25
P577publication date2014-09-26
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleActin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy
P478volume307

Reverse relations

cites work (P2860)
Q37139621A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation
Q91942580CapZ integrates several signaling pathways in response to mechanical stiffness
Q28268009Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε
Q92898904Hang on tight: reprogramming the cell with microstructural cues
Q46072833Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography
Q48258000Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis.
Q92983684Long non-coding RNA cardiac hypertrophy-associated regulator governs cardiac hypertrophy via regulating miR-20b and the downstream PTEN/AKT pathway
Q64970192PKC epsilon signaling effect on actin assembly is diminished in cardiomyocytes when challenged to additional work in a stiff microenvironment.
Q41717334The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
Q46137868Variation in stiffness regulates cardiac myocyte hypertrophy via signaling pathways

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