The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.

scientific article published on 19 September 2017

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-10838-5
P932PMC publication ID5605688
P698PubMed publication ID28928419

P50authorAbhinav KanwalQ60890961
Riyue BaoQ86979525
P2093author name stringMahesh P Gupta
Sadhana A Samant
Vinodkumar B Pillai
P2860cites workSIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stressQ24313709
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life spanQ24315083
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophyQ24555065
Regulation of myostatin activity and muscle growthQ24555817
Myostatin from the heart: local and systemic actions in cardiac failure and muscle wastingQ24609841
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cellsQ24626021
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failureQ24646933
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily memberQ28237287
The sirtuin SIRT6 regulates lifespan in male miceQ28260687
Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κBQ28389686
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferaseQ28505800
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6Q28509079
Identification of ubiquitin ligases required for skeletal muscle atrophyQ28582211
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alphaQ28588941
Mammalian sirtuins: biological insights and disease relevanceQ29614496
Recent progress in the biology and physiology of sirtuinsQ29617573
Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivityQ33419373
SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.Q51574303
Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism.Q51805331
Insulin-like growth factor-1 suppresses the Myostatin signaling pathway during myogenic differentiation.Q53436647
Myostatin, a transforming growth factor-? superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarctQ56874784
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivoQ73596145
Regulation of myostatin signaling by c-Jun N-terminal kinase in C2C12 cellsQ80775366
Resistance to body fat gain in 'double-muscled' mice fed a high-fat dietQ82226677
SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathwayQ87259676
Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasomeQ38105829
Myostatin/activin pathway antagonism: molecular basis and therapeutic potentialQ38110659
Transcriptional effects of chronic Akt activation in the heart.Q38290130
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Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle WastingQ38882868
Elevated expression of activins promotes muscle wasting and cachexia.Q39038278
Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathwayQ39983306
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Cancer cachexia is regulated by selective targeting of skeletal muscle gene productsQ40529830
NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubesQ40852716
Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 ExpressionQ41807919
Aberrant repair and fibrosis development in skeletal muscleQ41822988
Sirtuins at a glance.Q42650245
SIRT6 protects against pathological damage caused by diet-induced obesityQ43202807
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged miceQ43227383
Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitroQ44226350
Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatinQ44489665
A single ascending-dose study of muscle regulator ACE-031 in healthy volunteersQ45776651
Down-regulation of Akt/mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscleQ46359311
Myostatin is a human placental product that regulates glucose uptakeQ46933201
Myostatin activation in patients with advanced heart failure and after mechanical unloading.Q33803837
Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarctQ33864336
Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-reviewQ33956866
Cachexia: a new definitionQ34013455
The nuclear factor NF-kappaB pathway in inflammationQ34114512
Cachexia as a major underestimated and unmet medical need: facts and numbersQ34176827
Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational studyQ34187927
Myostatin decreases with aerobic exercise and associates with insulin resistanceQ34286092
SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in MiceQ34299195
Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophyQ34627816
Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner.Q34629952
Angiotensin II activates myostatin expression in cultured rat neonatal cardiomyocytes via p38 MAP kinase and myocyte enhance factor 2 pathwayQ34765114
Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney diseaseQ34813421
The role of myostatin in muscle wasting: an overviewQ35223987
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-JunQ35458082
Regulation of muscle mass by myostatinQ35912777
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6Q36246143
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cellsQ36364263
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant miceQ36451932
Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspectsQ36515547
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.Q36559986
Myostatin directly regulates skeletal muscle fibrosisQ36744190
Increased secretion and expression of myostatin in skeletal muscle from extremely obese women.Q37023094
NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseasesQ37075935
Myostatin (GDF-8) as a key factor linking muscle mass and bone structureQ37121916
Autophagy is induced in the skeletal muscle of cachectic cancer patientsQ37128604
Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic interventionQ37293352
Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanismQ37318200
Nuclear positioning in muscle development and diseaseQ37385211
Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt.Q37421047
NF-kappaB signaling: a tale of two pathways in skeletal myogenesisQ37731207
Signaling pathways perturbing muscle massQ37732100
Understanding the mechanisms and treatment options in cancer cachexiaQ38064733
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)11877
P577publication date2017-09-19
P1433published inScientific ReportsQ2261792
P1476titleThe histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
P478volume7

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cites work (P2860)
Q92845238A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice
Q90295069Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy
Q64097167Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation
Q59791878SIRT6 Is Involved in the Progression of Ovarian Carcinomas via β-Catenin-Mediated Epithelial to Mesenchymal Transition
Q51760982Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle.

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